Objective: The morbidity and mortality of infective endocarditis (IE) is still high despite diagnostic and therapeutic advances. Additionally, underlying risk profile and prognostic determinants of IE may exhibit regional disparities. Demonstration of changing trends of IE might be useful for a better patient care. Therefore, we aimed to explore clinical characteristics and the prognostic factors of IE in Turkey. Material and Method: Predisposing factors, clinical, echocardiographic, microbiologic and prognostic information of the IE patients who were diagnosed between the years 2009-2019 were analysed. Prognostic factors associated with IE were determined by univariate and multivariate regression analysis. Results: A total of 80 patients (50 males, 30 females) were diagnosed with IE. Seven of the patients had recurrent episodes of IE. Rheumatic valve disease (20 (25.00%)) and prosthetic heart valve (13 (16.25%)) were the most common underlying conditions. Sixty-seven (83.75%) patients had leftsided vegetation, 10 (12.50%) patients had right-sided vegetation and 3 patients had cardiac device infection without the involvement of the valves. Native valve endocarditis was detected in 61 (76.25%) patients. Staphylococcus was the most common microbiologic agent followed by streptococcus and enterococcus. Twenty-one (28.25%) patients died during the index hospitalization. The complicated clinical course was the most significant predictor of in-hospital mortality. Conclusion: Knowledge of predisposing factors and underlying conditions of IE are evolving. Patients with complicated in-hospital course have the highest risk for in-hospital mortality.