Yıl: 2022 Cilt: 5 Sayı: 2 Sayfa Aralığı: 225 - 232 Metin Dili: İngilizce DOI: 10.35377/saucis...1153071 İndeks Tarihi: 30-08-2022

A Relational Database Design for The Compounds Cytotoxically Active on Breast Cancer Cells

Öz:
Breast cancer is one of the most important global health problems affecting both developed and developing countries. The identification of anticancer compounds, effective on breast cancer cells, is of key importance in chemoprevention investigations and drug development studies. In the literature, there are numerous compounds that have been analyzed for their cytotoxic effects on breast cancer cells, but there is no database where the researchers who want to design a new study on breast cancer can find these compounds all at once. This paper presents a relational database that stores the data of natural and synthetic compounds cytotoxically active on breast cancer cells. The database contains 381 cytotoxicity results and data of 159 compounds, compiled from selected 80 studies. When all this data in our database was queried, it was found out that quercetin, which is a dietary flavonoid, is the most analyzed compound, and MCF-7 cell line is the most used breast cancer cell line.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • [1] WHO, “Newsroom Cancer," 2022. [Online]. Available: https://www.who.int/news-room/fact sheets/detail/cancer. [Accessed: 24-June-2022].
  • [2] H. Sung, J. Ferlay, R. L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal, and F. Bray, “Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries," CA: A Cancer Journal for Clinicians, vol. 71, no. 3, pp. 209-249, 2021.
  • [3] S. Łukasiewicz, M. Czeczelewski, A. Forma, J. Baj 3, R. Sitarz, and A. Stanisławek, “Breast Cancer—Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies— An Updated Review,” Cancers, vol. 13, no. 17, pp. 1-30, 2021 266–275, 2021.
  • [4] F. Leonessa and R. Clarke, ‘’ATP binding cassette transporters and drug resistance in breast cancer,” Endocrine-Related Cancer, vol. 10, pp. 43–73, 2003.
  • [5] T. Saeki, T. Tsuruo, W. Sato, and K. Nishikawsa, “Drug resistance in chemotherapy for breast cancer,” Cancer Chemotherapy and Pharmacology, vol. 56, pp. 84-89, 2005.
  • [6] N. L. Vukovic, A. D. Obradovic, M. D. Vukic, D. Jovanovic, and P. M. Djurdjevic, “Cytotoxic, proapoptotic and antioxidative potential of flavonoids isolated from propolis against colon (HCT 116) and breast (MDA-MB-231) cancer cell lines,” Food Research International, vol. 106, pp. 71-80, 2018.
  • [7] A. Damianaki, et al., “Potent Inhibitory Action of Red Wine Polyphenols on Human Breast Cancer Cells,” Journal of Cellular Biochemistry, vol. 78, pp. 429-441, 2000. Sakarya University Journal of Computer and Information Sciences
  • [8] H. Nakagawa, Y. Kiyozuka, Y. Uemura, H. Senzaki, N. Shikata, K. Hioki, an A. Tsubura, “Resveratrol inhibits human breast cancer cell growth and may mitigate the effect of linoleic acid, a potent breast cancer cell stimulator,” J. Cancer Res. Clin. Oncol., vol. 127, pp. 258-264, 2001.
  • [9] E. Safarzadeh, et al., “The Cytotoxic and Apoptotic Effects of Scrophularia Atropatana Extracts on Human Breast Cancer Cells,” Advanced Pharmaceutical Bulletin, vol. 7, no.3, pp. 381-389, 2017.
  • [10] E. Pierpaoli, A. G. Arcamone, F. Buzzetti, P. Lombardi, C. Salvatore, and M. Provinciali, “Antitumor effect of novel berberine derivatives in breast cancer cells,” BioFactors, vol. 39, no.6, pp. 672-679, 2013.
  • [11] R. Vennila, S. Kamalraj, and J. Muthumary, “In vitro Studies on anticancer activity of fungal taxol against human breast cancer cell line MCF-7 cells,” Asian Pacific Journal of Tropical Biomedicine, vol. 2, no. 2, pp. 1159-1161, 2012.
  • [12] I. Turan, S. Demir, S. Misir, K. Kilinc, A. Mentese, Y. Aliyazicioglu, and O. Deger, “Cytotoxic Effect of Turkish Propolis on Liver, Colon, Breast, Cervix and Prostate Cancer Cell Lines,” Tropical Journal of Pharmaceutical Research, vol. 14, no. 5, pp. 777-782, 2015.
  • [13] E. F. Codd, “A Relational Model of Data for Large Shared Data Banks,” Communications of the ACM, vol. 13, no. 6, pp. 377-387, 1970.
  • [14] Y. Bassil, “A Comparative Study on the Performance of the Top DBMS Systems,” Journal of Computer Science & Research, vol. 1, no. 1, pp. 20-31, 2012.
  • [15] S. Sumathi and S. Esakkirajan, Fundamentals of Relational Database Management Systems.Berlin, Heidelberg: Springer-Berlin Heidelberg, 2007.
  • [16] K. Ito, “Relational Database,” 2021. [Online]. Available: https://www.czc.hokudai.ac.jp/bioinform/pdf/2021-08-30-RDB-KI.pdf. [Accessed: 02-June-2022].
  • [17] N. Jatana, S. Puri, M. Ahuja, I. Kathuria, and D. Gosain, “A Survey and Comparison of Relational and Non-Relational Database,” International Journal of Engineering Research & Technology (IJERT), vol.1, no. 6, pp. 1-5, 2012.
  • [18] M. Takeshima, M. Ono, T. Higuchi, C. Chen, T. Hara, and S. Nakano, “Anti-proliferative and apoptosis-inducing activity of lycopene against three subtypes of human breast cancer cell lines”, Cancer Science, vol. 105, no. 3, pp. 252-257, 2014.
  • [19] J. Duo, G. G. Ying, G. W. Wang, and L. Zhang, “Quercetin inhibits human breast cancer cell proliferation and induces apoptosis via Bcl-2 and Bax regulation”, Molecular Medicine Reports, vol. 5, pp. 1453-1456, 2012.
  • [20] A. S. Alsabah, A. H. Abd, A. M. Al-Shammari, “Cytotoxicity of Xanthium Strumarium against Breast Cancer Cell Lines”, Journal of Global Pharma Technology, vol. 10, no. 3, pp. 767-776, 2018.
  • [21] A. Ligresti, et al., “Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma”, The Journal of Pharmacology and Experimental Therapeutics, vol. 318, no. 3, pp. 1375-1387, 2006.
  • [22] P. Prakash, R. M. Russell, and N. I. Krinsky, “In Vitro Inhibition of Proliferation of Estrogen Dependent and Estrogen-Independent Human Breast Cancer Cells Treated with Carotenoids or Retinoids”, The Journal of Nutrition, vol. 131, no. 5, pp. 1574-1580, 2001.
  • [23] J. A. Alosi, D. E. McDonald, J. S. Schneider, A. R. Privette, and D. W. McFadden, “Pterostilbene Inhibits Breast Cancer In Vitro Through Mitochondrial Depolarization and Induction of Caspase Dependent Apoptosis,” Journal of Surgical Research, vol. 161, pp. 195-201, 2010.
  • [24] Microsoft, “How to define relationships between tables in an Access database,” 2022. [Online]. Available:https://docs.microsoft.com/en-us/office/troubleshoot/access/define-table-relationships. [Accessed: 30-May-22].
  • [25] E. Akadal, Veritabanı Tasarlama Atölyesi. İstanbul, Türkmen Kitabevi, 2021
APA OKTAY Z, EROL Ç, Arda N (2022). A Relational Database Design for The Compounds Cytotoxically Active on Breast Cancer Cells. , 225 - 232. 10.35377/saucis...1153071
Chicago OKTAY Zeynep,EROL ÇİĞDEM,Arda Nazli A Relational Database Design for The Compounds Cytotoxically Active on Breast Cancer Cells. (2022): 225 - 232. 10.35377/saucis...1153071
MLA OKTAY Zeynep,EROL ÇİĞDEM,Arda Nazli A Relational Database Design for The Compounds Cytotoxically Active on Breast Cancer Cells. , 2022, ss.225 - 232. 10.35377/saucis...1153071
AMA OKTAY Z,EROL Ç,Arda N A Relational Database Design for The Compounds Cytotoxically Active on Breast Cancer Cells. . 2022; 225 - 232. 10.35377/saucis...1153071
Vancouver OKTAY Z,EROL Ç,Arda N A Relational Database Design for The Compounds Cytotoxically Active on Breast Cancer Cells. . 2022; 225 - 232. 10.35377/saucis...1153071
IEEE OKTAY Z,EROL Ç,Arda N "A Relational Database Design for The Compounds Cytotoxically Active on Breast Cancer Cells." , ss.225 - 232, 2022. 10.35377/saucis...1153071
ISNAD OKTAY, Zeynep vd. "A Relational Database Design for The Compounds Cytotoxically Active on Breast Cancer Cells". (2022), 225-232. https://doi.org/10.35377/saucis...1153071
APA OKTAY Z, EROL Ç, Arda N (2022). A Relational Database Design for The Compounds Cytotoxically Active on Breast Cancer Cells. Sakarya University Journal of Computer and Information Sciences (Online), 5(2), 225 - 232. 10.35377/saucis...1153071
Chicago OKTAY Zeynep,EROL ÇİĞDEM,Arda Nazli A Relational Database Design for The Compounds Cytotoxically Active on Breast Cancer Cells. Sakarya University Journal of Computer and Information Sciences (Online) 5, no.2 (2022): 225 - 232. 10.35377/saucis...1153071
MLA OKTAY Zeynep,EROL ÇİĞDEM,Arda Nazli A Relational Database Design for The Compounds Cytotoxically Active on Breast Cancer Cells. Sakarya University Journal of Computer and Information Sciences (Online), vol.5, no.2, 2022, ss.225 - 232. 10.35377/saucis...1153071
AMA OKTAY Z,EROL Ç,Arda N A Relational Database Design for The Compounds Cytotoxically Active on Breast Cancer Cells. Sakarya University Journal of Computer and Information Sciences (Online). 2022; 5(2): 225 - 232. 10.35377/saucis...1153071
Vancouver OKTAY Z,EROL Ç,Arda N A Relational Database Design for The Compounds Cytotoxically Active on Breast Cancer Cells. Sakarya University Journal of Computer and Information Sciences (Online). 2022; 5(2): 225 - 232. 10.35377/saucis...1153071
IEEE OKTAY Z,EROL Ç,Arda N "A Relational Database Design for The Compounds Cytotoxically Active on Breast Cancer Cells." Sakarya University Journal of Computer and Information Sciences (Online), 5, ss.225 - 232, 2022. 10.35377/saucis...1153071
ISNAD OKTAY, Zeynep vd. "A Relational Database Design for The Compounds Cytotoxically Active on Breast Cancer Cells". Sakarya University Journal of Computer and Information Sciences (Online) 5/2 (2022), 225-232. https://doi.org/10.35377/saucis...1153071