Investigation of the Relationship Between HMGB1 and Obesity in the Adrenal Gland

Erdal, Muhammed; Aydın Alkan, Işınsu; Oztas, Emin; ZUHAL, BERRİN; Kocaman, Adem

doi:10.37990/medr.1087598

Investigation of the Relationship Between HMGB1 and Obesity in the Adrenal Gland

Muhammed ERDAL, (Gülhane Askeri Hastanesi, Histoloji ve Embriyoloji Anabilim Dalı, Ankara, Türkiye)

Berrin Zuhal ALTUNKAYNAK, (Okan Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, İstanbul, Türkiye)

Adem KOCAMAN, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Samsun, Türkiye)

Işınsu Aydın Alkan, (Nevşehir Hacı Bektaş Veli Üniversitesi, Diş Hekimliği Fakültesi, Temel Bilimler Bölümü, Nevşehir, Türkiye)

Emin Oztas (Gülhane Askeri Hastanesi, Histoloji ve Embriyoloji Anabilim Dalı, Ankara, Türkiye)

Medical records-international medical journal (Online)

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Yıl: 2022 Cilt: 4 Sayı: 2 Sayfa Aralığı: 242 - 250 Metin Dili: İngilizce DOI: 10.37990/medr.1087598 İndeks Tarihi: 27-09-2022

Investigation of the Relationship Between HMGB1 and Obesity in the Adrenal Gland

Öz:

Aim: The interaction between obesity and increased production of pro-inflammatory cytokines results the existence of inflammation HMGB1 secreted from the adrenal gland can play a role in inflammation pathways. The aim of this study is to explain the link between HMGB1 and obesity in the adrenal gland. Material and Methods: In this study; eighteen female Wistar Albino rats were divided into two groups: untreated control group (n=8) and obese group (n=10). The rats in obese group were fed with high fat diet for ten weeks. Morphometric parameters of adrenal gland were assessed by using stereological techniques. The expression of high mobility group box protein 1 (HMGB1) in adrenal gland was evaluated. Results: At the end of the analyses; mean volumes of zona fasciculate, zona reticularis, and medulla were significantly increased in obese group. Also, the number of HMGB1 stained cells was significantly increased in the obese group in comparison to control group.Conclusion: The results suggest that obesity may be one of the reasons of inflammation and hypertrophy in the adrenal gland. HMGB1 may provide a novel perspective into the anti-inflammatory therapeutic strategies in obese patients.

Anahtar Kelime: Adrenal gland HMGB1 inflammation obesity stereology

Böbreküstü Bezinde HMGB1 ile Obezite İlişkisinin Araştırılması

Öz:

Amaç: Obezite ile artan proinflamatuar sitokin üretimi arasındaki etkileşim sonucu inflamasyonun varlığı adrenal bezden salgılanan HMGB1 inflamasyon yolaklarında rol oynayabilir. Bu çalışmanın amacı, adrenal bezde HMGB1 ile obezite arasındaki bağlantıyı açıklamaktır.Materyal ve Metot: Bu çalışmada; on sekiz dişi Wistar Albino sıçanı tedavi edilmeyen kontrol grubu (n=8) ve obez grup (n=10) olmak üzere iki gruba ayrıldı. Obez gruptaki ratlar on hafta süreyle yüksek yağlı diyetle beslenirken, control grubu standart diyet ile beslendi. Adrenal bezin morfometrik parametreleri ve mobilite grubu kutu protein 1 (HMGB1) ekspresyonu stereolojik teknikler kullanılarak değerlendirildi. Bulgular: Analizler sonunda; zona fasikülata, zona retikülaris ve medulla ortalama hacimlerinim obez grupta anlamlı olarak arttığı görüldü. Ayrıca obez grupta HMGB1 ile boyanmış hücre sayısı kontrol grubuna göre önemli ölçüde artmıştı.Sonuç: Sonuçlar obezitenin adrenal bezdeki inflamasyon ve hipertrofi nedenlerinden biri olabileceğini düşündürmektedir. HMGB1, obez hastalarda anti-inflamatuar terapötik stratejilere yeni bir bakış açısı sağlayabilir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Erdal M, ZUHAL B, Kocaman A, Aydın Alkan I, Oztas E (2022). Investigation of the Relationship Between HMGB1 and Obesity in the Adrenal Gland. , 242 - 250. 10.37990/medr.1087598
Chicago	Erdal Muhammed,ZUHAL BERRİN,Kocaman Adem,Aydın Alkan Işınsu,Oztas Emin Investigation of the Relationship Between HMGB1 and Obesity in the Adrenal Gland. (2022): 242 - 250. 10.37990/medr.1087598
MLA	Erdal Muhammed,ZUHAL BERRİN,Kocaman Adem,Aydın Alkan Işınsu,Oztas Emin Investigation of the Relationship Between HMGB1 and Obesity in the Adrenal Gland. , 2022, ss.242 - 250. 10.37990/medr.1087598
AMA	Erdal M,ZUHAL B,Kocaman A,Aydın Alkan I,Oztas E Investigation of the Relationship Between HMGB1 and Obesity in the Adrenal Gland. . 2022; 242 - 250. 10.37990/medr.1087598
Vancouver	Erdal M,ZUHAL B,Kocaman A,Aydın Alkan I,Oztas E Investigation of the Relationship Between HMGB1 and Obesity in the Adrenal Gland. . 2022; 242 - 250. 10.37990/medr.1087598
IEEE	Erdal M,ZUHAL B,Kocaman A,Aydın Alkan I,Oztas E "Investigation of the Relationship Between HMGB1 and Obesity in the Adrenal Gland." , ss.242 - 250, 2022. 10.37990/medr.1087598
ISNAD	Erdal, Muhammed vd. "Investigation of the Relationship Between HMGB1 and Obesity in the Adrenal Gland". (2022), 242-250. https://doi.org/10.37990/medr.1087598

APA	Erdal M, ZUHAL B, Kocaman A, Aydın Alkan I, Oztas E (2022). Investigation of the Relationship Between HMGB1 and Obesity in the Adrenal Gland. Medical records-international medical journal (Online), 4(2), 242 - 250. 10.37990/medr.1087598
Chicago	Erdal Muhammed,ZUHAL BERRİN,Kocaman Adem,Aydın Alkan Işınsu,Oztas Emin Investigation of the Relationship Between HMGB1 and Obesity in the Adrenal Gland. Medical records-international medical journal (Online) 4, no.2 (2022): 242 - 250. 10.37990/medr.1087598
MLA	Erdal Muhammed,ZUHAL BERRİN,Kocaman Adem,Aydın Alkan Işınsu,Oztas Emin Investigation of the Relationship Between HMGB1 and Obesity in the Adrenal Gland. Medical records-international medical journal (Online), vol.4, no.2, 2022, ss.242 - 250. 10.37990/medr.1087598
AMA	Erdal M,ZUHAL B,Kocaman A,Aydın Alkan I,Oztas E Investigation of the Relationship Between HMGB1 and Obesity in the Adrenal Gland. Medical records-international medical journal (Online). 2022; 4(2): 242 - 250. 10.37990/medr.1087598
Vancouver	Erdal M,ZUHAL B,Kocaman A,Aydın Alkan I,Oztas E Investigation of the Relationship Between HMGB1 and Obesity in the Adrenal Gland. Medical records-international medical journal (Online). 2022; 4(2): 242 - 250. 10.37990/medr.1087598
IEEE	Erdal M,ZUHAL B,Kocaman A,Aydın Alkan I,Oztas E "Investigation of the Relationship Between HMGB1 and Obesity in the Adrenal Gland." Medical records-international medical journal (Online), 4, ss.242 - 250, 2022. 10.37990/medr.1087598
ISNAD	Erdal, Muhammed vd. "Investigation of the Relationship Between HMGB1 and Obesity in the Adrenal Gland". Medical records-international medical journal (Online) 4/2 (2022), 242-250. https://doi.org/10.37990/medr.1087598