Relationship between plasma osmolality and neutrophil/lymphocyte ratio in heart failure with reduced ejection fraction

Akyüz, Aydın; Ozkaramanli Gur, Demet; alpsoy, seref; BAYKIZ, DERYA

Relationship between plasma osmolality and neutrophil/lymphocyte ratio in heart failure with reduced ejection fraction

Derya BAYKIZ, (İstanbul Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye)

Aydın AKYÜZ, (Namık Kemal Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Tekirdağ, Türkiye)

Demet ÖZKARAMANLI GÜR, (Namık Kemal Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Tekirdağ, Türkiye)

Seref Alpsoy (Namık Kemal Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Tekirdağ, Türkiye)

Annals of Medical Research

1 3

Yıl: 2022 Cilt: 29 Sayı: 8 Sayfa Aralığı: 777 - 783 Metin Dili: İngilizce İndeks Tarihi: 30-09-2022

Relationship between plasma osmolality and neutrophil/lymphocyte ratio in heart failure with reduced ejection fraction

Öz:

Aim: Heart failure (HF), a progressive disease, is accompanied by chronic inflammation and changes in osmolality. The neutrophil-to-lymphocyte ratio (NLR) demonstrates a sys- temic inflammatory response in most diseases; however, the relationship between plasma osmolality and the systemic inflammatory response in HF patients is not yet clear. There- fore, we aimed to investigate the possible associations of NLR with plasma osmolality levels in patients with HF. Materials and Methods: The present study included 189 consecutive patients with chronic HF with an ejection fraction (EF) of <40%. They were classified into four groups based on admission plasma osmolality quartiles: hypo-osmolar (first quartile), normo- hypo-osmolar (second quartile), normo-hyperosmolar (third quartile), and hyperosmolar (fourth quartile). We evaluated the relationship between NLR, plasma osmolality, type-B natriuretic peptide (BNP), and the New York Heart Association (NYHA) functional class. Results: The hyperosmolar group had an increased NLR (p = 0.007). The presence of NYHA class 3–4 functional capacity, high-sensitivity C-reactive protein, and high osmo- lality were independent predictors of increased NLR. In correlation analysis, osmolality was significantly positively correlated with NLR (r = 0.201, p = 0.011). Conclusion: Higher NLR values may be associated with increased plasma osmolality, which may indicate an increased inflammatory status in the HF phenomenon.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	BAYKIZ D, Akyüz A, Ozkaramanli Gur D, alpsoy s (2022). Relationship between plasma osmolality and neutrophil/lymphocyte ratio in heart failure with reduced ejection fraction. , 777 - 783.
Chicago	BAYKIZ DERYA,Akyüz Aydın,Ozkaramanli Gur Demet,alpsoy seref Relationship between plasma osmolality and neutrophil/lymphocyte ratio in heart failure with reduced ejection fraction. (2022): 777 - 783.
MLA	BAYKIZ DERYA,Akyüz Aydın,Ozkaramanli Gur Demet,alpsoy seref Relationship between plasma osmolality and neutrophil/lymphocyte ratio in heart failure with reduced ejection fraction. , 2022, ss.777 - 783.
AMA	BAYKIZ D,Akyüz A,Ozkaramanli Gur D,alpsoy s Relationship between plasma osmolality and neutrophil/lymphocyte ratio in heart failure with reduced ejection fraction. . 2022; 777 - 783.
Vancouver	BAYKIZ D,Akyüz A,Ozkaramanli Gur D,alpsoy s Relationship between plasma osmolality and neutrophil/lymphocyte ratio in heart failure with reduced ejection fraction. . 2022; 777 - 783.
IEEE	BAYKIZ D,Akyüz A,Ozkaramanli Gur D,alpsoy s "Relationship between plasma osmolality and neutrophil/lymphocyte ratio in heart failure with reduced ejection fraction." , ss.777 - 783, 2022.
ISNAD	BAYKIZ, DERYA vd. "Relationship between plasma osmolality and neutrophil/lymphocyte ratio in heart failure with reduced ejection fraction". (2022), 777-783.

APA	BAYKIZ D, Akyüz A, Ozkaramanli Gur D, alpsoy s (2022). Relationship between plasma osmolality and neutrophil/lymphocyte ratio in heart failure with reduced ejection fraction. Annals of Medical Research, 29(8), 777 - 783.
Chicago	BAYKIZ DERYA,Akyüz Aydın,Ozkaramanli Gur Demet,alpsoy seref Relationship between plasma osmolality and neutrophil/lymphocyte ratio in heart failure with reduced ejection fraction. Annals of Medical Research 29, no.8 (2022): 777 - 783.
MLA	BAYKIZ DERYA,Akyüz Aydın,Ozkaramanli Gur Demet,alpsoy seref Relationship between plasma osmolality and neutrophil/lymphocyte ratio in heart failure with reduced ejection fraction. Annals of Medical Research, vol.29, no.8, 2022, ss.777 - 783.
AMA	BAYKIZ D,Akyüz A,Ozkaramanli Gur D,alpsoy s Relationship between plasma osmolality and neutrophil/lymphocyte ratio in heart failure with reduced ejection fraction. Annals of Medical Research. 2022; 29(8): 777 - 783.
Vancouver	BAYKIZ D,Akyüz A,Ozkaramanli Gur D,alpsoy s Relationship between plasma osmolality and neutrophil/lymphocyte ratio in heart failure with reduced ejection fraction. Annals of Medical Research. 2022; 29(8): 777 - 783.
IEEE	BAYKIZ D,Akyüz A,Ozkaramanli Gur D,alpsoy s "Relationship between plasma osmolality and neutrophil/lymphocyte ratio in heart failure with reduced ejection fraction." Annals of Medical Research, 29, ss.777 - 783, 2022.
ISNAD	BAYKIZ, DERYA vd. "Relationship between plasma osmolality and neutrophil/lymphocyte ratio in heart failure with reduced ejection fraction". Annals of Medical Research 29/8 (2022), 777-783.