Traumatic brain injury (TBI) is the most common cause of death among young population. Approximately 10-15% of these patients, are associated with many severe comorbid conditions, are discharged in vegetative state. Amantadine acts as both a NMDA receptor antagonist and an indirect dopamine agonist. But its exact mechanism of action is still unknown. It is frequently use to increase alertness in patients with TBI. In this presentation, we aimed to present the eight cases with TBI which were treated with Amantadine in İntensive Care Unit (ICU). The characteristics of the cases are given in Table 1. All of patients with traumatic brain injury were intubated and unconscious upon arrival. We used Thiopental sodium for sedation to all patients. Amantadine sulfate treatment was started in the first hour as 200 mg / day and treatment was continued for at least 10 days. Traumatic brain injury (TBI) are serious health problems with social and economic consequences. Although there are many methods for to increase neurological recovery, there is still no specific treatment. Amantadine is a reliable and frequently used drug for to improve the neurological recovery of the patients with TBI. In the literature, the studies on the use of amantadine in patients with TBI was compared with the control group and various parameters. These studies were shown that neurological recovery was better in the amantadine group. We used some variables such as Glasgow Coma Scale (GKS), Full Outline of Unresponsiveness (FOUR) scale and duration of stay at ıcu and hospital. FOUR scale are better reflects the neurological status in intubated patients. Although there are a limited number of articles indicating efficacy, new studies on amantadine use, dose, and duration are needed in patients with TBI.