An Extensive Review on the Use of Feed Additives Against Fish Diseases and Improvement of Health Status of Fish in Turkish Aquaculture Sector

Yılmaz, Sevdan; Yılmaz, Ebru; Yigit, Murat; ERGÜN, SEBAHATTİN

doi:10.4194/AQUAST710

An Extensive Review on the Use of Feed Additives Against Fish Diseases and Improvement of Health Status of Fish in Turkish Aquaculture Sector

Sevdan Yılmaz, (Çanakkale Onsekiz Mart Üniversitesi, Deniz Bilimleri ve Teknolojisi Fakültesi, Su Ürünleri Bölümü, Çanakkale, Türkiye.)

Sebahattin Ergün, (Çanakkale Onsekiz Mart Üniversitesi, Deniz Bilimleri ve Teknolojisi Fakültesi, Su Ürünleri Bölümü, Çanakkale, Türkiye.)

Murat Yiğit, (Çanakkale Onsekiz Mart Üniversitesi, Deniz Bilimleri ve Teknolojisi Fakültesi, Deniz Teknolojisi Mühendisliği Bölümü, Çanakkale, Türkiye.)

Ebru Yılmaz (Aydın Adnan Menderes Üniversitesi, Su Ürünleri Fakültesi, Su Ürünleri Bölümü, Aydın, Türkiye.)

Aquaculture Studies

11 1

Yıl: 2022 Cilt: 22 Sayı: 3 Sayfa Aralığı: 49 - 62 Metin Dili: İngilizce DOI: 10.4194/AQUAST710 İndeks Tarihi: 07-10-2022

An Extensive Review on the Use of Feed Additives Against Fish Diseases and Improvement of Health Status of Fish in Turkish Aquaculture Sector

Öz:

Aquaculture is the second-fastest-growing sector in the world after informatics and its. Average growth of aquaculture is annually ~8.8% over the last 30 years. Turkey has great potential in terms of fish production and the number of fish farms started to increase rapidly. Fish production in intensive culture conditions has enlarged possible threats of contagious disease outbreaks due to high stocking densities, water quality or environmental gradient, etc., as well as the combination of all these factors together. Depending on animal husbandry situations and organizational conditions, gradation of the aquatic surroundings and outbreaks of bacteriological diseases may well cause production losses around 30-40% in aquaculture facilities. Some fish diseases reported most repeatedly in Turkish aquaculture facilities are Vibriosis, Furunculosis, Streptococcosis, Lactococcosis, Aeromonas septicemia, Yersiniosis, Photobacteriosis and Flavobacteriosis. Antibiotics, disinfectants and chemotherapeutics used for the prevention and treatment of diseases result in residual antibiotics and chemicals in fish products, microorganisms resistant to antibiotics and damages to the aquatic environment and human health. This situation has led researchers to use alternative feed additives in fish diets such as medicinal plant, herbal extracts, phytochemicals, plant secondary metabolites, immunostimulants and probiotics. This review includes research conducted in Turkey between the years 2001 and 2020, and aims to summarize the findings regarding the use of medicinal plant, herbal extracts, phytochemicals, plant secondary metabolites and immunostimulants in fish feed to prevent and treat diseases, improve immunity, increase disease resistance, and reduce stress in fish towards a better management and best aquaculture practice for the sustainability of the growing aquaculture industry in the region and worldwide

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

Acar, U. (2018a). Effects of diet supplemented with ethanolic extract of propolis on growth performance, hematological and serum biochemical parameters and disease resistance of Mozambique tilapia (Oreochromis mossambicus) against Streptococcus iniae. Aquaculture, 495, 339-344. https://doi.org/10.1016/j.aquaculture.2018.06.007
Acar, U. (2018b). Sarı kantaron (Hypericum perforatum) yağının sazan yavrularının (Cyprinus carpio) büyüme performansı ve bazı kan parametreleri üzerine etkisi. Alınteri Zirai Bilimler Dergisi, 33(1), 21-27. https://doi.org/10.28955/alinterizbd.343202
Acar, U., Kesbic, O. S., Inanan, B. E., & Yilmaz, S. (2019). Effects of dietary Bergamot (Citrus bergamia) peel oil on growth, haematology and immune response of European sea bass (Dicentrarchus labrax) juveniles. Aquaculture Research, 50(11), 3305-3312. https://doi.org/10.1111/are.14288
Acar, U., Kesbic, O. S., Yilmaz, S., Gultepe, N., & Turker, A. (2015). Evaluation of the effects of essential oil extracted from sweet orange peel (Citrus sinensis) on growth rate of tilapia (Oreochromis mossambicus) and possible disease resistance against Streptococcus iniae. Aquaculture, 437, 282-286. https://doi.org/10.1016/j.aquaculture.2014.12.015
Acar, U., Parrino, V., Kesbic, O. S., Lo Paro, G., Saoca, C., Abbate, F., Yilmaz, S., & Fazio, F. (2018). Effects of different levels of pomegranate seed oil on some blood parameters and disease resistance against Yersinia ruckeri in rainbow trout. Frontiers in Physiology, 9, 596. https://doi.org/10.3389/fphys.2018.00596 Altınterim,
B. & Aksu, Ö. (2019). Masere sarımsak (Allium sativum Limne) ve Tunceli sarımsağı (Allium tuncelianum Kollman) yağlarının yoğun stoklanmış gökkuşağı alabalıklarının (Oncorhynchus mykiss W.) bazı kan parametrelerine ve NBT (Nitroblue Tetrazolium) seviyelerine etkileri. BAUN Fen Bilimleri Enstitüsü Dergisi, 21(2): 716-723. https://doi.org/10.25092/baunfbed.637083
Altınterı ̇m, B., Öztürk, E., Kutluyer, F., & Aksu, Ö. (2018). Yeşil çay yağının gökkuşağı alabalıklarının (Oncorhynchus mykiss) yem değerlendirme oranına ve hematolojik parametrelerine etkileri. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 13(2): 159-164. https://doi.org/ 10.17094/ataunivbd.296989
Agnew, W., & Barnes, A. C. (2007). Streptococcus iniae: An aquatic pathogen of global veterinary significance and a challenging candidate for reliable vaccination. Veterinary Microbiology, 122(1-2), 1-15. https://doi.org/10.1016/j.vetmic.2007.03.002
Aksit, D. (2016). Balık yetiştiriciliğinde antibakteriyel direnç ve önemi. Turkiye Klinikleri Veterinary Sciences- Pharmacology and Toxicology-Special Topics, 2(1), 47- 54. https://www.turkiyeklinikleri.com/article/tr-balik- yetistiriciliginde-antibakteriyel-direnc-ve-onemi- 75638.html
Akyüz, A. P., Dernekbaşı, S., & Karayücel, İ. (2018). Yüksek sıcaklıkla oksidatif strese maruz bırakılan gökkuşağı alabalığında (Oncorhynchus mykiss Walbaum, 1792), karayemiş yaprağı (Laurocerasus officinalis Roem.) ekstraktının büyüme, yaşama oranı ve bazı antioksidan enzimler üzerine etkisi. Su Ürünleri Dergisi, 35(2): 131- 139. https://doi.org/10.12714/egejfas.2018.35.2.05
Almabrok, A. A., Amhamed, I. D., Mohamed, G. A., Bilen, S., & Altief, T. A. S. (2018). Effect of Tilia tomentosa methanolic extract on growth performance, digestive enzyme activity, immune system and haematological indices of common carp (Cyprinus carpio). Marine Science and Technology Bulletin, 7(1), 12-20. https://doi.org/10.33714/masteb.421047
Altunoglu, Y. C., Bilen, S., Ulu, F., & Biswas, G. (2017). Immune responses to methanolic extract of black cumin (Nigella sativa) in rainbow trout (Oncorhynchus mykiss). Fish & Shellfish Immunology, 67, 103-109. https://doi.org/10.1016/j.fsi.2017.06.002
Amhamed, I. D., Mohamed, G. A., Almabrok, A. A., Altief, T. A. S., & Bilen, S. (2018). Efficacy of dietary Chenopodium album extract on some health parameters, digestive enzymes and growth performance in juvenile Cyprinus carpio. Alınteri Zirai Bilimler Dergisi, 33(2), 165-176. https://doi.org/10.28955/alinterizbd.412455
Arslan, G., Sonmez, A. Y., & Yanik, T. (2018). Effects of grape Vitis vinifera seed oil supplementation on growth, survival, fatty acid profiles, antioxidant contents and blood parameters in rainbow trout (Oncorhynchus mykiss). Aquaculture Research, 49(6), 2256-2266. https://doi.org/10.1111/are.13686
Austin, B., & Austin, D.A. (2016). Aeromonadaceae representatives (motile aeromonads). In B. Austin & D.A. Austin (Eds.), Bacterial fish pathogens: Disease of farmed and wild fish (sixth ed., pp 161-214). Springer. https://doi.org/10.1007/978-3-319-32674-0
Baba, E., Acar, U., Ontas, C., Kesbic, O. S., & Yilmaz, S. (2016a). The use of Avena sativa extract against Aeromonas hydrophila and its effect on growth performance, hematological and immunological parameters in common carp (Cyprinus carpio). Italian Journal of Animal Science, 15(2), 325-333. https://doi.org/10.1080/1828051X.2016.1185977
Baba, E., Acar, U., Ontas, C., Kesbic, O. S., & Yilmaz, S. (2016b). Evaluation of Citrus limon peels essential oil on growth performance, immune response of Mozambique tilapia Oreochromis mossambicus challenged with Edwardsiella tarda. Aquaculture, 465, 13-18. https://doi.org/10.1016/j.aquaculture.2016.08.023
Baba, E., Acar, U., Yilmaz, S., Ontas, C., & Kesbic, O.S. (2017). Pre challenge and post challenge haemato immunological changes in Oreochromis niloticus (Linnaeus, 1758) fed argan oil against Lactococcus garvieae. Aquaculture Research, 48(8), 4563-4572. https://doi.org/10.1111/are.13282
Baba, E., Acar, U., Yilmaz, S., Zemheri, F., & Ergun, S. (2018). Dietary olive leaf (Olea europea L.) extract alters some immune gene expression levels and disease resistance to Yersinia ruckeri infection in rainbow trout Oncorhynchus mykiss. Fish & Shellfish Immunology, 79, 28-33. https://doi.org/10.1016/j.fsi.2018.04.063
Baba, E., Ulukoy, G., & Ontas, C. (2015). Effects of feed supplemented with Lentinula edodes mushroom extract on the immune response of rainbow trout, Oncorhynchus mykiss, and disease resistance against Lactococcus garvieae. Aquaculture, 448, 476-482. https://doi.org/10.1016/j.aquaculture.2015.04.031
Bilen, S., Altief, T. A. S., Ozdemir, K. Y., Salem, M. A. O., Terzi, E., & Guney, K. (2020a). Effect of lemon balm (Melissa officinalis) extract on growth performance, digestive and antioxidant enzyme activities, and immune responses in rainbow trout (Oncorhynchus mykiss). Fish Physiology and Biochemistry, 46(1), 471-481. https://doi.org/10.1007/s10695-019-00737-z
Bilen, S., Altunoglu, Y. C., Ulu, F., & Biswas, G. (2016a). Innate immune and growth promoting responses to caper (Capparis spinosa) extract in rainbow trout (Oncorhynchus mykiss). Fish & Shellfish Immunology, 57, 206-212. https://doi.org/10.1016/j.fsi.2016.08.040
Bilen, S., Karga, M., Altunoglu, Y. C., Ulu, F., & Biswas, G. (2020b). Immune responses and growth performance of the aqueous methanolic extract of Malva sylvestris in Oncorhynchus mykiss. Marine Science and Technology Bulletin, 9(2), 159-167. https://doi.org/10.33714/masteb.746951
Bilen, S., Kenanoglu, O. N., Terzi, E., Ozdemir, R. C., & Sonmez, A. Y. (2019). Effects of tetra (Cotinus coggygria) and common mallow (Malva sylvestris) plant extracts on growth performance and immune response in Gilthead sea bream (Sparus aurata) and European sea bass (Dicentrarchus labrax). Aquaculture, 734251. https://doi.org/10.1016/j.aquaculture.2019.734251
Bilen, S., Ozkan, O., Alagoz, K., & Ozdemir, K. Y. (2018). Effect of dill (Anethum graveolens) and garden cress (Lepidium sativum) dietary supplementation on growth performance, digestive enzyme activities and immune responses of juvenile common carp (Cyprinus carpio). Aquaculture, 495, 611-616. https://doi.org/10.1016/j.aquaculture.2018.06.037
Bilen, S., Unal, S., & Guvensoy, H. (2016b). Effects of oyster mushroom (Pleurotus ostreatus) and nettle (Urtica dioica) methanolic extracts on immune responses and resistance to Aeromonas hydrophila in rainbow trout (Oncorhynchus mykiss). Aquaculture, 454, 90-94. https://doi.org/10.1016/j.aquaculture.2015.12.010
Bilen, S., Yilmaz, S., & Bilen, A. M. (2013). Influence of tetra (Cotinus coggygria) extract against Vibrio anguillarum infection in koi carp, Cyprinus carpio with reference to haematological and immunological changes. Turkish Journal of Fisheries and Aquatic Sciences, 13(3), 517- 522. https://doi.org/10.4194/1303-2712-v13_3_16
Capkin, E., Ozdemir, S., Ozturk, R. C., & Altinok, I. (2017). Determination and transferability of plasmid mediated antibiotic resistance genes of the bacteria isolated from rainbow trout. Aquaculture Research, 48(11), 5561- 5575. https://doi.org/10.1111/are.13378
Capkin, E., Terzi, E., & Altinok, I. (2015). Occurrence of antibiotic resistance genes in culturable bacteria isolated from Turkish trout farms and their local aquatic environment. Diseases of Aquatic Organisms, 114(2), 127-137. https://doi.org/10.3354/dao02852
Collins, M., Farrow, J., Phillips, B., & Kandler, O. (1983). Streptococcus garvieae sp. nov. and Streptococcus plantarum sp. nov. Microbiology, 129(11), 3427-3431. https://doi.org/10.1099/00221287-129-11-3427
Cortez, R., Luna-Vital, D. A., Margulis, D., & De Mejia, E. G. (2017). Natural pigments: stabilization methods of anthocyanins for food applications. Comprehensive Reviews in Food Science and Food Safety, 16(1), 180- 198. https://doi.org/10.1111/1541-4337.12244
Diler, O., & Gormez, O. (2019). Gökkuşağı alabalıklarında (Oncorhynchus mykiss) bitkisel yem katkı maddelerinden Artemisia campestris L. ve Artemisia absinthium L’un bağırsak histomorfolojisi üzerine etkisi. Süleyman Demirel Üniversitesi Eğirdir Su Ürünleri Fakültesi Dergisi, 15(1), 10-18. https://doi.org/10.22392/egirdir.422547
Diler, O., Atabay, A., & Gormez, O. (2017a). Bitkisel katkı maddesi Artemisia vulgaris’ in gökkuşağı alabalıklarında (Oncorhyncus mykiss, Walbaum) büyüme performansı ve antioksidan aktivite üzerine etkisi. Süleyman Demirel Üniversitesi Eğirdir Su Ürünleri Fakültesi Dergisi, 13(2 ), 119-131. https://dergipark.org.tr/tr/pub/egirdir/issue/30873/26 8454
Diler, O., Gormez, O., Diler, I., & Metin, S. (2017b). Effect of oregano (Origanum onites L.) essential oil on growth, lysozyme and antioxidant activity and resistance against Lactococcus garvieae in rainbow trout, Oncorhynchus mykiss (Walbaum). Aquaculture Nutrition, 23(4), 844- 851. https://doi.org/10.1111/anu.12451
Diler, O., Gormez, O., Metin, S., Ilhan, I., & Diler, I. (2017c). Origanum vulgare L. uçucu yağının gökkuşağı alabalıkları (Oncorhyncus mykiss)’nda büyüme, lizozim ve antioksidan aktivite ve Vibrio anguillarum’a karşı direnç üzerine etkisi. Süleyman Demirel Üniversitesi Eğirdir Su Ürünleri Fakültesi Dergisi, 13(1), 42-57. https://doi.org/10.22392/egirdir.252029
Diler, O., Gormez, O., Terzioglu, S., & Atabay, A. (2018a). Pelin otu (Artemisia Vulgaris L)’nun gökkuşağı alabalıklarında (Oncorhynchus mykiss, walbaum) hastalıklara karşı direnç ve spesifik olmayan bağışıklık sistemi üzerine etkisi. Journal of Aquaculture Engineering and Fisheries Research, 4(1), 1-11. https://doi.org/10.3153/JAEFR18001
Diler, O., Gormez, O., Terzioglu, S., & Bayrak, H. (2018b). Gökkuşağı alabalığı (Oncorhynchus mykiss) yetiştiriciliğinde görülen spironucleosis enfeksiyonlarının tedavisinde Artemisia campestris (L)’in kullanımı. Süleyman Demirel Üniversitesi Eğirdir Su Ürünleri Fakültesi Dergisi, 14(4), 312-323. https://doi.org/10.22392/egirdir.407905
Dugenci, S. K., & Candan, A. (2001). Gökkuşağı alabalıklarında (Oncorhynchus mykiss, Walbaum) bazı immunostimulanların spesifik olmayan bağışıklık sistemi üzerine etkisi. Turkısh Journal of Veterinary and Animal Sciences, 27(6), 1253-1260. https://app.trdizin.gov.tr/publication/paper/detail/TXp BMk16ZzQ
Dugenci, S. K., Arda, N. & Candan, A. (2003). Some medicinal plants as immunostimulant for fish. Journal of Ethnopharmacology, 88(1), 99-106. https://doi.org/10.1016/s0378-8741(03)00182-x
Duman, S., & Sahan, A. (2018). Some hematological and non- specific immune responses of rosehip (Rosa canina)-Fed Russian Sturgeon (Acipenser gueldenstaedtii Brandt & Ratzeburg, 1833) to Mycobacterium salmoniphilum. Brazilian Archives of Biology and Technology, 61, 1-17. http://dx.doi.org/10.1590/1678-4324-2018180283
Eldar, A., & Ghittino, C. (1999). Lactococcus garvieae and Streptococcus iniae infections in rainbow trout Oncorhynchus mykiss: similar, but different diseases. Diseases of Aquatic Organisms, 36(3), 227-31. http://dx.doi.org/10.3354/dao036227
Er., A., & Kayıs, S. (2015). Çay bitkisi (Camellia sinensis) tohumunun gökkuşağı alabalıklarında (Oncorhynchus mykiss) Aeromonas hydrophila enfeksiyonuna karşı kullanımının araştırılması. El-Cezeri Science and Engineering Journal, 2(3), 67-74. https://doi.org/10.31202/ecjse.67145
Ewing, W., McWhorter, A., Escobar, M., & Lubin, A. (1965). Edwardsiella, a new genus of Enterobacteriaceae based on a new species, E. tarda. International Bulletin of Bacteriological Nomenclature and Taxonomy, 15(1), 33- 38. https://doi.org/10.1099/00207713-15-1-33
FAO (2018). FAO Yearbook, Fishery and Aquaculture Statistics. http://www.fao.org/3/cb1213t/CB1213T.pdf
Frans, I., Michiels, C. W., Bossier, P., Willems, K. A., Lievens, B., & Rediers, H. (2011). Vibrio anguillarum as a fish pathogen: Virulence factors, diagnosis and prevention. Journal of Fish Diseases, 34(9), 643-661. https://doi.org/10.1111/j.1365-2761.2011.01279.x
Gauthier, D. T. (2015). Bacterial zoonoses of fishes: A review and appraisal of evidence for linkages between fish and human infections. The Veterinary Journal, 203(1), 27-35. https://doi.org/10.1016/j.tvjl.2014.10.028
Gudding, R., Lillehaug, A., & Evensen, O. (2014). Fish Vaccination. John Wiley & Sons. https://doi.org/10.1002/9781118806913
Gulec, A. K., Danabas, D., Ural, M., Seker, E., Arslan, A., & Serdar, O. (2013). Effect of mixed use of thyme and fennel oils on biochemical properties and electrolytes in rainbow trout as a response to Yersinia ruckeri infection. Acta Veterinaria Brno, 82(3), 297-302. https://doi.org/10.2754/avb201382030297
Gullu, K., Acar, U., Kesbic, O. S., Yilmaz, S., Agdamar, S., Ergun, S., & Turker, A. (2016). Beneficial effects of oral allspice, Pimenta dioica powder supplementation on the hemato immunological and serum biochemical responses of Oreochromis mossambicus. Aquaculture Research, 47(9), 2697-2704. https://doi.org/10.1111/are.12717
Gultepe, N. (2020). Protective effect of d-limonene derived from orange peel essential oil against Yersinia ruckeri in rainbow trout. Aquaculture Reports, 18, 100417. https://doi.org/10.1016/j.aqrep.2020.100417
Gultepe, N., Acar, U., Kesbic, O. S., Yilmaz, S., Yildirim, O., & Turker, A. (2014). Effects of dietary Tribulus terrestris extract supplementation on growth, feed utilization, hematological, immunological, and biochemical variables of Nile tilapia Oreochromis niloticus. The Israeli Journal of Aquaculture-Bamidgeh, 66, 1-9. https://doi.org/10.46989/001c.20774
Guven, A., & Yalcin, S. (2017). Effects of dietary yeast autolysate on performance, some blood parameters and lysozyme activity in rainbow trout (Oncorhynchus mykiss). Ankara Üniversitesi Veteriner Fakültesi Dergisi, 64(3), 177-182. https://doi.org/10.1501/Vetfak_0000002796
Horne, M. T., & Barnes, A. C. (1999). Enteric redmouth disease (Yersinia ruckeri), in P.T.K. Woo and D.W. Bruno (Eds.), Fish Diseases and Disorders, Viral, Bacterial and Fungal Infections, CABI Publishing, Wallingford.
Ispir, U., & Dorucu, M. (2005). A study on the effects of levamisole on the immune system of rainbow trout (Oncorhynchus mykiss, walbaum). Turkish Journal of Veterinary and Animal Sciences, 29, 1169-1176. https://dergipark.org.tr/tr/download/article- file/132674
Kesbic, O. S. (2019a). Effects of juniper berry oil on growth performance and blood parameters in common carp (Cyprinus carpio). Aquaculture Research, 50(1), 342-349. https://doi.org/10.1111/are.13908
Kesbic, O. S. (2019b). Effects of the cinnamon oil (Cinnamomum verum) on growth performance and blood parameters of rainbow trout (Oncorhynchus mykiss). Turkish Journal of Agriculture-Food Science and Technology, 7(2), 370-376. https://doi.org/10.24925/turjaf.v7i2.370-376.2360
Kesbic, O. S., Acar, U., Yilmaz, S., & Aydin, O. D. (2020a). Effects of bergamot (Citrus bergamia) peel oil-supplemented diets on growth performance, haematology and serum biochemical parameters of Nile tilapia (Oreochromis niloticus). Fish Physiology Biochemistry, 46, 103-110. https://doi.org/10.1007/s10695-019-00700-y
Kesbic, O. S., Parrino, V., Acar, U., Yilmaz, S., Paro, G. L., & Fazio, F. (2020b). Effects of Monterey cypress (Cupressus macrocarpa Hartw) leaf essential oil as a dietary supplement on growth performance and haematological and biochemical parameters of common carp (Cyprinus carpio L.). Annals of Animal Science, 1-33. https://doi.org/10.2478/aoas-2020-0041
Kıvrak, E & Didinen, B.I. (2017). Gökkuşağı alabalığı (Oncorhynchus mykiss, Walbaum 1792)’nın yemlerine biberiye bitki (Rosmarinus officinalis) yağı ilavesinin balıkların büyüme performansı ve bazı kan parametrelerine olan etkileri. Yunus Research Bulletin, 2, 193-202. https://doi.org/10.17693/yunusae.vi.287094
Lee, C. S. (2015). Dietary Nutrients, Additives and Fish Health. Wiley-Blackwell. https://doi.org/10.1002/9781119005568
Ozturk, R. C., & Altinok, I. (2014). Bacterial and viral fish diseases in Turkey. Turkish Journal of Fisheries and Aquatic Sciences, 14(1), 275-297. https://doi.org/10.4194/1303-2712-v14_1_30
Parrino, V., Kesbic, O. S., Acar, U., & Fazio, F. (2019). Hot pepper (Capsicum sp.) oil and its effects on growth performance and blood parameters in rainbow trout (Oncorhynchus mykiss). Natural Product Research, 34(22), 3226-3230. https://doi.org/10.1080/14786419.2018.1550769
Öntaş, C., Uluköy, G., BABA, E., & Mammadov, R. (2020). Crocus cancellatus subsp. mazziaricus (Herbert) mathew bitki ekstraktının avrupa deniz levrek balığı (Dicentrarchus labrax, L. 1758) doğal bağışıklık sistemi üzerine etkisi. Acta Aquatica Turcica, 16(1), 148-157. https://doi.org/10.22392/actaquatr.622606
Ravelo, C., Magarinos, B., López-Romalde, S., Toranzo, A. E., & Romalde, J. L. (2003). Molecular fingerprinting of fish- pathogenic Lactococcus garvieae strains by random amplified polymorphic DNA analysis. Journal of Clinical Microbiology, 41(2), 751-756. https://doi.org/10.1128/JCM.41.2.751-756.2003
Rehulka, J., Marejková, M., & Petráš, P. (2012) Edwardsiellosis in farmed rainbow trout (Oncorhynchus mykiss). Aquaculture Research, 43(11), 1628-1634. https://doi.org/10.1111/j.1365-2109.2011.02968.x
Sahan, A., & Duman, S. (2010). Influence ofbeta-1, 3/1, 6 glucan applications on some non-specific cellular immune response and haematologic parameters of healthy Nile tilapia (Oreochromis niloticus L., 1758) Turkish Journal of Veterinary and Animal Sciences, 34(1), 75-81. https://doi.org/10.3906/vet-0810-21
Sahan, A., Duman, S., Colak, S. O., Cinar, E., & Bilgin, R. (2017). Determination of some hematological and non-specific immune defences, oxidative stress and histopathological status in rainbow trout (Oncorhynchus mykiss) fed rosehip (Rosa canina) to Yersinia ruckeri. Turkish Journal of Fisheries and Aquatic Sciences, 17(1), 91-100. https://doi.org/10.4194/1303-2712-v17_1_11
Sahan, A., Ozutok, S., & Kurutas, E.B. (2016). Determination of some hematological parameters and antioxidant capacity in Nile tilapia (Oreochromis niloticus Linnaeus, 1758) fed ginger (Zingiber Officinale Roscoe) to Aeromonas hydrophila. Turkish Journal of Fisheries and Aquatic Sciences, 16, 197-204. https://doi.org/10.4194/1303-2712-v16_1_20
Savaşer, S., Akçimen, U., Ceylan, M., Bektaş, Z.H., Yener, O., & Bulut, C. (2019). Zencefil (Zingiber officinale)’in gökkuşağı alabalıklarında (Oncorhynchus mykiss Walbaum) immunostimulant ve büyüme destekleyici olarak kullanımı. Journal of Limnology and Freshwater Fisheries Research 5(2), 121-135. https://doi.org/10.17216/limnofish.487812
Schleifer, K. H., Klaus, J., Dvorak, C., Kilpper-Balz, R., Collins, M. D., & Fischer, W. (1985). Transfer of Streptococcus lactis and related streptococci to the genus Lactococcus gen. nov. Systematic and Applied Microbiology, 6(2), 183- 195. https://doi.org/10.1016/S0723-2020(85)80052-7
Teixeira, L. M., Merquior, V. L. C., Vianni, C. E., Carvalho, G. S., Fracalanzza, S. E. L., Steigerwalt, A. G., Brenner, D. J., & Facklam, R. R. (1996). Phenotypic and genotypic characterization of a typical Lactococcus garvieae strains isolated from water buffalos with subclinical mastitis and confirmation of L. garvieae as a senior subjective synonym of Enterococcus seriolicida. International Journal of Systematic and Evolutionary Microbiology, 46(3), 664-668. https://doi.org/10.1099/00207713-46- 3-664
Terzioglu, S., & Diler, O. (2016). Effect of dietary sage (Salvia officinalis L.), licorice root (Glycyrrhize glabra L.), blueberry (Vaccinium myrtillus L.) and echinaceae (Echinacea angustifolia Hell) on nonspecific immunity and resistance to Vibrio anguillarum infection in rainbow trout, (Oncorhynchus mykiss). Süleyman Demirel Üniversitesi Eğirdir Su Ürünleri Fakültesi Dergisi, 12(2), 110-118. https://doi.org/10.22392/egirdir.284921
TUIK (2019). Su ürünleri istatistikleri. https://data.tuik.gov.tr/Kategori/GetKategori?p=tarim- 111&dil=1
Ulukoy, G., Baba, E., & Birincioglu, S. S. (2016). Effects of dietary Lentinula edodes extract on liver and gut histology of rainbow trout (Oncorhynchus mykiss, Walbaum 1792). Fish & Shellfish Immunology, 53, 106. https://doi.org/10.1016/j.fsi.2016.04.068
Ulukoy, G., Metin, S., Kubilay, A., Guney, S., Yildirim, P., Guzel Seydim, Z., Kok-Tas, T., & Gumus, E. (2017). The effect of kefir as a dietary supplement on nonspecific immune response and disease resistance in juvenile rainbow trout, Oncorhynchus mykiss (Walbaum 1792). Journal of the World Aquaculture Society, 48(2), 248-256. https://doi.org/10.1111/jwas.12336
Woo, P.T.K., & Bruno, D.W. (2017). Fish diseases and disorders:, Volume 3: Viral, bacterial and fungal infections., In: Woo PTK, Cipriano RC (eds): Wallingford, UK, CAB International.
Woo, P. T. K., & Cipriano, R. C. (2017). Fish viruses and bacteria: pathobiology and protection. CABI Publishing. Wallingford, UK. https://doi.org/10.1079/9781780647784.0000
Yarsan, E. (2013). Veteriner hekimlikte antibiyotikler (pratik bilgiler rehberi). Güneş Tıp Kitabevi.
Yildirim, O. (2008). Aquafeed industry in Turkey: its aquafeed projections towards the year 2015. Turkish Journal of Fisheries and Aquatic Sciences, 8(1), 93-98. https://www.trjfas.org/abstract.php?lang=en&id=595
Yilmaz, S., Ergun, S., Kaya, H., & Gurkan, M. (2014). Influence of Tribulus terrestris extract on the survival and histopathology of Oreochromis mossambicus (Peters, 1852) fry before and after Streptococcus iniae infection. Journal of Applied Ichthyology, 30(5), 994-1000. https://doi.org/10.1111/jai.12458
Yilmaz, E. (2019d). Effects of dietary anthocyanin on innate immune parameters, gene expression responses, and ammonia resistance of Nile tilapia (Oreochromis niloticus). Fish & Shellfish Immunology, 93, 694-701. https://doi.org/10.1016/j.fsi.2019.08.033
Yilmaz, E. (2020). Effect of dietary carob (Ceratonia siliqua) syrup on blood parameters, gene expression responses and ammonia resistance in tilapia (Oreochromis niloticus). Aquaculture Research, 51(5), 1903-1912. https://doi.org/10.1111/are.14540
Yilmaz, E., & Er, M. (2019). Effects of figs and rosemary extracts on rainbow trout (Oncorhynchus mykiss) on growth performance and blood parameters. Acta Aquatica Turcica, 15(1), 19-25. https://doi.org/10.22392/egirdir.429630
Yilmaz, E., Celik, E. S., Ergun., S., & Yilmaz, S. (2020b). Effects of dietary olive pomace oil on growth performance, some ımmune parameters and disease resistance (Lactococcus garvieae) of rainbow trout (Oncorhynchus mykiss). Journal of Anatolian Environmental and Animal Sciences, 5(4), 597-604. https://doi.org/10.35229/jaes.798086
Yilmaz, E., Ergun, S., & Yilmaz S. (2020a). Effects of supplementation of L-alliin and oleuropein into rainbow trout (Oncorhynchus mykiss) feeds on growth performance, some immune parameters and disease resistance (Aeromonas salmonicida subsp. salmonicida). Journal of Limnology and Freshwater Fisheries Research, 6(3), 180-188. https://doi.org/10.17216/limnofish.746677
Yilmaz, E., Ergun, S., & Yilmaz, S. (2015b). Influence of carvacrol on the growth performance, hematological, non-specific immune and serum biochemistry parameters in rainbow trout (Oncorhynchus mykiss). Food and Nutrition Sciences, 6(5), 523-531. https://doi.org/10.4236/fns.2015.65054
Yilmaz, S. (2019a). Effects of dietary caffeic acid supplement on antioxidant, immunological and liver gene expression responses, and resistance of Nile tilapia, Oreochromis niloticus to Aeromonas veronii. Fish & Shellfish Immunology, 86, 384-392. https://doi.org/10.1016/j.fsi.2018.11.068
Yilmaz, S. (2019b). Karabaş otu (Lavandula stoechas) yağının sazan balığı (Cyprinus carpio) yemlerine ilavesinin büyüme performansı ve bazı kan parametreleri üzerine etkileri. ÇOMÜ Ziraat Fakültesi Dergisi, 7(1), 187-193. https://doi.org/10.33202/comuagri.4513
Yilmaz, S. (2019c). Effects of dietary blackberry syrup supplement on growth performance, antioxidant, and immunological responses, and resistance of Nile tilapia, Oreochromis niloticus to Plesiomonas shigelloides. Fish & Shellfish Immunology, 84, 1125-1133. https://doi.org/10.1016/j.fsi.2018.11.012
Yilmaz, S., & Ergun, S. (2014). Dietary supplementation with allspice Pimenta dioica reduces the occurrence of streptococcal disease during first feeding of Mozambique tilapia fry. Journal of Aquatic Animal Health, 26(3), 144-148. https://doi.org/10.1080/08997659.2014.893459
Yilmaz, S., & Ergun, S. (2018). Trans-cinnamic acid application for rainbow trout (Oncorhynchus mykiss): I. Effects on haematological, serum biochemical, non-specific immune and head kidney gene expression responses. Fish & Shellfish Immunology, 78, 140-157. https://doi.org/10.1016/j.fsi.2018.04.034
Yilmaz, S., Acar, U., Kesbic, O. S., Gultepe, N., & Ergun, S. (2015a). Effects of dietary allspice, Pimenta dioica powder on physiological responses of Oreochromis mossambicus under low pH stress. SpringerPlus, 4(1), 719. https://doi.org/10.1186/s40064-015-1520-7
Yilmaz, S., Ergun, S., & Celik, E. S. (2013a). Effect of dietary herbal supplements on some physiological conditions of sea bass Dicentrarchus labrax. Journal of Aquatic Animal Health, 25(2), 98-103. https://doi:10.1080/08997659.2013.768561
Yilmaz, S., Ergun, S., & Celik, E. S. (2018b). The effect of dietary carob (Ceratonia siliqua) syrup on growth performance, haematological, serum biochemical and immunological parameters in tilapia (Oreochromis mossambicus). Turkish Journal of Agriculture - Food Science and Technology, 6(12), 1820-1826. https://doi.org/10.24925/turjaf.v6i12.1820-1826.2184
Yilmaz, S., Ergun, S., & Celik, E.S. (2016). Effect of dietary spice supplementations on welfare status of sea bass, Dicentrarchus labrax L. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences, 86(1), 229-237. https://doi.org/10.1007/s40011-014-0444-2
Yilmaz, S., Ergun, S., & Soytas, N. (2013b). Herbal supplements are useful for preventing streptococcal disease during first-feeding of tilapia fry, Oreochromis mossambicus. The Israeli Journal of Aquaculture-Bamidgeh, 65, 1-5. https://ija.scholasticahq.com/issue/2837
Yilmaz, S., Ergun, S., & Soytas, N. (2013c). Dietary supplementation of cumin (Cuminum cyminum) preventing streptococcal disease during first-feeding of Mozambique tilapia (Oreochromis mossambicus). Journal of BioScience and Biotechnology, 2(2), 117-124. http://www.jbb.uni- plovdiv.bg/documents/27807/59545/jbb_2013- 2%282%29-pages_117-124.pdf/57e419a9-12f8-46ee- 9a46-8daa97447acd?version=1.0
Yilmaz, S., Ergun, S., & Turk, N. (2012). Effects of cumin- supplemented diets on growth and disease (Streptococcus iniae) resistance of tilapia (Oreochromis mossambicus). The Israeli Journal of Aquaculture- Bamidgeh, 64, 1-5. http://hdl.handle.net/10524/23593
Yilmaz, S., Ergun, S., Celik, E. S., Yigit, M., & Bayizit, C. (2019a). Dietary trans cinnamic acid application for rainbow trout (Oncorhynchus mykiss): II. Effect on antioxidant status, digestive enzyme, blood biochemistry and liver antioxidant gene expression responses. Aquaculture Nutrition, 25(6), 1207-1217. https://doi.org/10.1111/anu.12935
Yilmaz, S., Ergun, S., Yigit, M., Yilmaz, E., & Ahmadifar, E. (2020c). Dietary supplementation of black mulberry (Morus nigra) syrup improves the growth performance, innate immune response, antioxidant status, gene expression responses, and disease resistance of Nile tilapia (Oreochromis niloticus). Fish & Shellfish Immunology, 107, 211-217. https://doi.org/10.1016/j.fsi.2020.09.041
Yilmaz, S., Sova, M., & Ergun, S. (2018a). Antimicrobial activity of trans cinnamic acid and commonly used antibiotics against important fish pathogens and nonpathogenic isolates. Journal of Applied Microbiology, 125(6), 1714- 1727. https://doi.org/10.1111/jam.14097
Yonar, M. E., Yonar, S. M., Ispir, U., & Ural, M. S. (2019). Effects of curcumin on haematological values, immunity, antioxidant status and resistance of rainbow trout (Oncorhynchus mykiss) against Aeromonas salmonicida subsp. achromogenes. Fish & Shellfish Immunology, 89, 83-90. https://doi.org/10.1016/j.fsi.2019.03.038
emheri-Navruz, F., Acar, U., & Yilmaz, S. (2019). Dietary supplementation of olive leaf extract increases haematological, serum biochemical parameters and immune related genes expression level in common carp (Cyprinus carpio) juveniles. Fish & Shellfish Immunology, 89, 672-676. https://doi.org/10.1016/j.fsi.2019.04.037

APA	Yılmaz S, ERGÜN S, Yigit M, Yılmaz E (2022). An Extensive Review on the Use of Feed Additives Against Fish Diseases and Improvement of Health Status of Fish in Turkish Aquaculture Sector. , 49 - 62. 10.4194/AQUAST710
Chicago	Yılmaz Sevdan,ERGÜN SEBAHATTİN,Yigit Murat,Yılmaz Ebru An Extensive Review on the Use of Feed Additives Against Fish Diseases and Improvement of Health Status of Fish in Turkish Aquaculture Sector. (2022): 49 - 62. 10.4194/AQUAST710
MLA	Yılmaz Sevdan,ERGÜN SEBAHATTİN,Yigit Murat,Yılmaz Ebru An Extensive Review on the Use of Feed Additives Against Fish Diseases and Improvement of Health Status of Fish in Turkish Aquaculture Sector. , 2022, ss.49 - 62. 10.4194/AQUAST710
AMA	Yılmaz S,ERGÜN S,Yigit M,Yılmaz E An Extensive Review on the Use of Feed Additives Against Fish Diseases and Improvement of Health Status of Fish in Turkish Aquaculture Sector. . 2022; 49 - 62. 10.4194/AQUAST710
Vancouver	Yılmaz S,ERGÜN S,Yigit M,Yılmaz E An Extensive Review on the Use of Feed Additives Against Fish Diseases and Improvement of Health Status of Fish in Turkish Aquaculture Sector. . 2022; 49 - 62. 10.4194/AQUAST710
IEEE	Yılmaz S,ERGÜN S,Yigit M,Yılmaz E "An Extensive Review on the Use of Feed Additives Against Fish Diseases and Improvement of Health Status of Fish in Turkish Aquaculture Sector." , ss.49 - 62, 2022. 10.4194/AQUAST710
ISNAD	Yılmaz, Sevdan vd. "An Extensive Review on the Use of Feed Additives Against Fish Diseases and Improvement of Health Status of Fish in Turkish Aquaculture Sector". (2022), 49-62. https://doi.org/10.4194/AQUAST710

APA	Yılmaz S, ERGÜN S, Yigit M, Yılmaz E (2022). An Extensive Review on the Use of Feed Additives Against Fish Diseases and Improvement of Health Status of Fish in Turkish Aquaculture Sector. Aquaculture Studies, 22(3), 49 - 62. 10.4194/AQUAST710
Chicago	Yılmaz Sevdan,ERGÜN SEBAHATTİN,Yigit Murat,Yılmaz Ebru An Extensive Review on the Use of Feed Additives Against Fish Diseases and Improvement of Health Status of Fish in Turkish Aquaculture Sector. Aquaculture Studies 22, no.3 (2022): 49 - 62. 10.4194/AQUAST710
MLA	Yılmaz Sevdan,ERGÜN SEBAHATTİN,Yigit Murat,Yılmaz Ebru An Extensive Review on the Use of Feed Additives Against Fish Diseases and Improvement of Health Status of Fish in Turkish Aquaculture Sector. Aquaculture Studies, vol.22, no.3, 2022, ss.49 - 62. 10.4194/AQUAST710
AMA	Yılmaz S,ERGÜN S,Yigit M,Yılmaz E An Extensive Review on the Use of Feed Additives Against Fish Diseases and Improvement of Health Status of Fish in Turkish Aquaculture Sector. Aquaculture Studies. 2022; 22(3): 49 - 62. 10.4194/AQUAST710
Vancouver	Yılmaz S,ERGÜN S,Yigit M,Yılmaz E An Extensive Review on the Use of Feed Additives Against Fish Diseases and Improvement of Health Status of Fish in Turkish Aquaculture Sector. Aquaculture Studies. 2022; 22(3): 49 - 62. 10.4194/AQUAST710
IEEE	Yılmaz S,ERGÜN S,Yigit M,Yılmaz E "An Extensive Review on the Use of Feed Additives Against Fish Diseases and Improvement of Health Status of Fish in Turkish Aquaculture Sector." Aquaculture Studies, 22, ss.49 - 62, 2022. 10.4194/AQUAST710
ISNAD	Yılmaz, Sevdan vd. "An Extensive Review on the Use of Feed Additives Against Fish Diseases and Improvement of Health Status of Fish in Turkish Aquaculture Sector". Aquaculture Studies 22/3 (2022), 49-62. https://doi.org/10.4194/AQUAST710