Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds

Aklamuz, Akın; ULGEN, MERT; Coşkun, Göknil Pelin; İnce, Ufuk

doi:10.17776/csj.1105811

Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds

Göknil Pelin COŞKUN, (Acıbadem Mehmet Ali Aydınlar Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, İstanbul, Türkiye)

Akın AKLAMUZ, (Acıbadem Mehmet Ali Aydınlar Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, İstanbul, Türkiye)

Ufuk İNCE, (Erciyes Üniversitesi, Eczacılık Fakültesi, Farmasötik Mikrobiyoloji Anabilim Dalı, Kayseri, Türkiye)

MERT ULGEN (Acıbadem Mehmet Ali Aydınlar Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, İstanbul, Türkiye)

Cumhuriyet Science Journal

6 0

Yıl: 2022 Cilt: 43 Sayı: 3 Sayfa Aralığı: 384 - 390 Metin Dili: İngilizce DOI: 10.17776/csj.1105811 İndeks Tarihi: 14-10-2022

Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds

Öz:

Bacterial infection today occupies a tremendous place in world health. The infection diseases were kept under control after the development of penicillin and further studies were performed on the development of new antibacterial agents. However, to date, bacterial resistance caused a big failure in the treatment of infectious disease and therefore, development of new antibacterial agents became important for human health. In the present study, we have designed, synthesized and elucidated the structures of new hydrazide-hydrazone compounds and their hybrid amide derivatives. The structures of the compounds were elucidated with spectroscopic methods and their purity were proven by TLC, HPLC-MS analysis. The antibacterial and antifungal activity studies of the novel molecules were investigated on different strains. Among the synthesized compounds, AA3a and AA4a appeared to show promising antibacterial activity. None of the compounds showed significant antifungal activity on Candida albicans. The drug likeness properties and boiled-egg plot analysis were performed for all of the compounds. The novel molecules showed no violation on Lipinski’s rule of five and all the molecules showed good gastrointestinal absorption properties in the in silico studies.

Anahtar Kelime: 4-ASA Hydrazide Hydrazone Amide Antibacterial activity.

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Coşkun G, Aklamuz A, İnce U, ULGEN M (2022). Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds. , 384 - 390. 10.17776/csj.1105811
Chicago	Coşkun Göknil Pelin,Aklamuz Akın,İnce Ufuk,ULGEN MERT Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds. (2022): 384 - 390. 10.17776/csj.1105811
MLA	Coşkun Göknil Pelin,Aklamuz Akın,İnce Ufuk,ULGEN MERT Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds. , 2022, ss.384 - 390. 10.17776/csj.1105811
AMA	Coşkun G,Aklamuz A,İnce U,ULGEN M Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds. . 2022; 384 - 390. 10.17776/csj.1105811
Vancouver	Coşkun G,Aklamuz A,İnce U,ULGEN M Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds. . 2022; 384 - 390. 10.17776/csj.1105811
IEEE	Coşkun G,Aklamuz A,İnce U,ULGEN M "Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds." , ss.384 - 390, 2022. 10.17776/csj.1105811
ISNAD	Coşkun, Göknil Pelin vd. "Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds". (2022), 384-390. https://doi.org/10.17776/csj.1105811

APA	Coşkun G, Aklamuz A, İnce U, ULGEN M (2022). Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds. Cumhuriyet Science Journal, 43(3), 384 - 390. 10.17776/csj.1105811
Chicago	Coşkun Göknil Pelin,Aklamuz Akın,İnce Ufuk,ULGEN MERT Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds. Cumhuriyet Science Journal 43, no.3 (2022): 384 - 390. 10.17776/csj.1105811
MLA	Coşkun Göknil Pelin,Aklamuz Akın,İnce Ufuk,ULGEN MERT Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds. Cumhuriyet Science Journal, vol.43, no.3, 2022, ss.384 - 390. 10.17776/csj.1105811
AMA	Coşkun G,Aklamuz A,İnce U,ULGEN M Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds. Cumhuriyet Science Journal. 2022; 43(3): 384 - 390. 10.17776/csj.1105811
Vancouver	Coşkun G,Aklamuz A,İnce U,ULGEN M Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds. Cumhuriyet Science Journal. 2022; 43(3): 384 - 390. 10.17776/csj.1105811
IEEE	Coşkun G,Aklamuz A,İnce U,ULGEN M "Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds." Cumhuriyet Science Journal, 43, ss.384 - 390, 2022. 10.17776/csj.1105811
ISNAD	Coşkun, Göknil Pelin vd. "Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds". Cumhuriyet Science Journal 43/3 (2022), 384-390. https://doi.org/10.17776/csj.1105811