Efficacy and Safety of Direct-Acting Antivirals in Elderly Patients with Chronic Hepatitis C: A Nationwide Real-Life, Observational, Multicenter Study from Turkey

Öz:

Background: The number and proportion of elderly patients living with chronic hepatitis C are expected to increase in the coming years. We aimed to compare the real-world efficacy and safety of direct-acting antiviral treatment in elderly and younger Turkish adults infected with chronic hepatitis C. Methods: In this multicenter prospective study, 2629 eligible chronic hepatitis C patients treated with direct-acting antivirals between April 2017 and December 2019 from 37 Turkish referral centers were divided into 2 age groups: elderly (≥65 years) and younger adults (<65 years) and their safety was compared between 2 groups in evaluable population. Then, by matching the 2 age groups for demographics and pretreatment risk factors for a non-sustained virological response, a total of 1516 patients (758 in each group) and 1244 patients (622 in each group) from the modified evaluable population and per-protocol population were included in the efficacy analysis and the efficacy was compared between age groups. Results: The sustained virological response in the chronic hepatitis C patients was not affected by the age and the presence of cirrhosis both in the modified evaluable population and per-protocol population (P = .879, P = .508 for modified evaluable population and P = .058, P = .788 for per-protocol population, respectively). The results of the per-protocol analysis revealed that male gender, patients who had a prior history of hepatocellular carcinoma, patients infected with non-genotype 1 hepatitis C virus, and patients treated with sofosbuvir + ribavirin had a significantly lower sustained virological response 12 rates (P < .001, P = .047, P = .013, and P = .025, respectively). Conclusion: Direct-acting antivirals can be safely used to treat Turkish elderly chronic hepatitis C patients with similar favorable efficacy and safety as that in younger adults.

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Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ONLEN Y, Bal T, çabalak m, Oztoprak N, Didem sarı N, Kurtaran B, Şenateş E, Gunduz A, zerdali e, KARSEN H, Batirel A, KARAALİ R, GÜNER R, Yamazhan T, köse ş, Erben N, Ince N, Koksal I, Sarıgül F, Yörük G, komur s, Kaya S, Esen Ş, Gunal O, YILDIZ I, İNAN D, Barut S, NAMIDURU M, Tosun S, Türker K, Sener A, hizel k, Baykam N, Duygu F, Akıncı E, Can G, User U, GÜL H, AKBULUT A, Celebi G, Sunnetcioglu M, KARABAY O, kumbasar karaosmanoglu h, SIRMATEL F, Tabak F (2022). Efficacy and Safety of Direct-Acting Antivirals in Elderly Patients with Chronic Hepatitis C: A Nationwide Real-Life, Observational, Multicenter Study from Turkey. , 862 - 873. 10.5152/tjg.2022.21271
Chicago	ONLEN YÜSÜF,Bal Tayibe,çabalak mehmet,Oztoprak Nefise,Didem sarı Nagehan,Kurtaran Behice,Şenateş Ebubekir,Gunduz Alper,zerdali esra,KARSEN HASAN,Batirel Ayse,KARAALİ Rıdvan,GÜNER RAHMET,Yamazhan Tansu,köse şükran,Erben Nurettin,Ince Nevin,Koksal Iftihar,Sarıgül Figen,Yörük Gülşen,komur suheyla,Kaya Sibel,Esen Şaban,Gunal Ozgur,YILDIZ ILKNUR ESEN,İNAN DİLARA,Barut Sener,NAMIDURU Mustafa,Tosun Selma,Türker Kamuran,Sener Alper,hizel kenan,Baykam Nurcan,Duygu Fazilet,Akıncı Esragül,Can Güray,User Ulku,GÜL Hanefi Cem,AKBULUT AYHAN,Celebi Guven,Sunnetcioglu Mahmut,KARABAY OĞUZ,kumbasar karaosmanoglu hayat,SIRMATEL FATMA,Tabak Fehmi Efficacy and Safety of Direct-Acting Antivirals in Elderly Patients with Chronic Hepatitis C: A Nationwide Real-Life, Observational, Multicenter Study from Turkey. (2022): 862 - 873. 10.5152/tjg.2022.21271
MLA	ONLEN YÜSÜF,Bal Tayibe,çabalak mehmet,Oztoprak Nefise,Didem sarı Nagehan,Kurtaran Behice,Şenateş Ebubekir,Gunduz Alper,zerdali esra,KARSEN HASAN,Batirel Ayse,KARAALİ Rıdvan,GÜNER RAHMET,Yamazhan Tansu,köse şükran,Erben Nurettin,Ince Nevin,Koksal Iftihar,Sarıgül Figen,Yörük Gülşen,komur suheyla,Kaya Sibel,Esen Şaban,Gunal Ozgur,YILDIZ ILKNUR ESEN,İNAN DİLARA,Barut Sener,NAMIDURU Mustafa,Tosun Selma,Türker Kamuran,Sener Alper,hizel kenan,Baykam Nurcan,Duygu Fazilet,Akıncı Esragül,Can Güray,User Ulku,GÜL Hanefi Cem,AKBULUT AYHAN,Celebi Guven,Sunnetcioglu Mahmut,KARABAY OĞUZ,kumbasar karaosmanoglu hayat,SIRMATEL FATMA,Tabak Fehmi Efficacy and Safety of Direct-Acting Antivirals in Elderly Patients with Chronic Hepatitis C: A Nationwide Real-Life, Observational, Multicenter Study from Turkey. , 2022, ss.862 - 873. 10.5152/tjg.2022.21271
AMA	ONLEN Y,Bal T,çabalak m,Oztoprak N,Didem sarı N,Kurtaran B,Şenateş E,Gunduz A,zerdali e,KARSEN H,Batirel A,KARAALİ R,GÜNER R,Yamazhan T,köse ş,Erben N,Ince N,Koksal I,Sarıgül F,Yörük G,komur s,Kaya S,Esen Ş,Gunal O,YILDIZ I,İNAN D,Barut S,NAMIDURU M,Tosun S,Türker K,Sener A,hizel k,Baykam N,Duygu F,Akıncı E,Can G,User U,GÜL H,AKBULUT A,Celebi G,Sunnetcioglu M,KARABAY O,kumbasar karaosmanoglu h,SIRMATEL F,Tabak F Efficacy and Safety of Direct-Acting Antivirals in Elderly Patients with Chronic Hepatitis C: A Nationwide Real-Life, Observational, Multicenter Study from Turkey. . 2022; 862 - 873. 10.5152/tjg.2022.21271
Vancouver	ONLEN Y,Bal T,çabalak m,Oztoprak N,Didem sarı N,Kurtaran B,Şenateş E,Gunduz A,zerdali e,KARSEN H,Batirel A,KARAALİ R,GÜNER R,Yamazhan T,köse ş,Erben N,Ince N,Koksal I,Sarıgül F,Yörük G,komur s,Kaya S,Esen Ş,Gunal O,YILDIZ I,İNAN D,Barut S,NAMIDURU M,Tosun S,Türker K,Sener A,hizel k,Baykam N,Duygu F,Akıncı E,Can G,User U,GÜL H,AKBULUT A,Celebi G,Sunnetcioglu M,KARABAY O,kumbasar karaosmanoglu h,SIRMATEL F,Tabak F Efficacy and Safety of Direct-Acting Antivirals in Elderly Patients with Chronic Hepatitis C: A Nationwide Real-Life, Observational, Multicenter Study from Turkey. . 2022; 862 - 873. 10.5152/tjg.2022.21271
IEEE	ONLEN Y,Bal T,çabalak m,Oztoprak N,Didem sarı N,Kurtaran B,Şenateş E,Gunduz A,zerdali e,KARSEN H,Batirel A,KARAALİ R,GÜNER R,Yamazhan T,köse ş,Erben N,Ince N,Koksal I,Sarıgül F,Yörük G,komur s,Kaya S,Esen Ş,Gunal O,YILDIZ I,İNAN D,Barut S,NAMIDURU M,Tosun S,Türker K,Sener A,hizel k,Baykam N,Duygu F,Akıncı E,Can G,User U,GÜL H,AKBULUT A,Celebi G,Sunnetcioglu M,KARABAY O,kumbasar karaosmanoglu h,SIRMATEL F,Tabak F "Efficacy and Safety of Direct-Acting Antivirals in Elderly Patients with Chronic Hepatitis C: A Nationwide Real-Life, Observational, Multicenter Study from Turkey." , ss.862 - 873, 2022. 10.5152/tjg.2022.21271
ISNAD	ONLEN, YÜSÜF vd. "Efficacy and Safety of Direct-Acting Antivirals in Elderly Patients with Chronic Hepatitis C: A Nationwide Real-Life, Observational, Multicenter Study from Turkey". (2022), 862-873. https://doi.org/10.5152/tjg.2022.21271

APA	ONLEN Y, Bal T, çabalak m, Oztoprak N, Didem sarı N, Kurtaran B, Şenateş E, Gunduz A, zerdali e, KARSEN H, Batirel A, KARAALİ R, GÜNER R, Yamazhan T, köse ş, Erben N, Ince N, Koksal I, Sarıgül F, Yörük G, komur s, Kaya S, Esen Ş, Gunal O, YILDIZ I, İNAN D, Barut S, NAMIDURU M, Tosun S, Türker K, Sener A, hizel k, Baykam N, Duygu F, Akıncı E, Can G, User U, GÜL H, AKBULUT A, Celebi G, Sunnetcioglu M, KARABAY O, kumbasar karaosmanoglu h, SIRMATEL F, Tabak F (2022). Efficacy and Safety of Direct-Acting Antivirals in Elderly Patients with Chronic Hepatitis C: A Nationwide Real-Life, Observational, Multicenter Study from Turkey. Turkish Journal of Gastroenterology, 33(10), 862 - 873. 10.5152/tjg.2022.21271
Chicago	ONLEN YÜSÜF,Bal Tayibe,çabalak mehmet,Oztoprak Nefise,Didem sarı Nagehan,Kurtaran Behice,Şenateş Ebubekir,Gunduz Alper,zerdali esra,KARSEN HASAN,Batirel Ayse,KARAALİ Rıdvan,GÜNER RAHMET,Yamazhan Tansu,köse şükran,Erben Nurettin,Ince Nevin,Koksal Iftihar,Sarıgül Figen,Yörük Gülşen,komur suheyla,Kaya Sibel,Esen Şaban,Gunal Ozgur,YILDIZ ILKNUR ESEN,İNAN DİLARA,Barut Sener,NAMIDURU Mustafa,Tosun Selma,Türker Kamuran,Sener Alper,hizel kenan,Baykam Nurcan,Duygu Fazilet,Akıncı Esragül,Can Güray,User Ulku,GÜL Hanefi Cem,AKBULUT AYHAN,Celebi Guven,Sunnetcioglu Mahmut,KARABAY OĞUZ,kumbasar karaosmanoglu hayat,SIRMATEL FATMA,Tabak Fehmi Efficacy and Safety of Direct-Acting Antivirals in Elderly Patients with Chronic Hepatitis C: A Nationwide Real-Life, Observational, Multicenter Study from Turkey. Turkish Journal of Gastroenterology 33, no.10 (2022): 862 - 873. 10.5152/tjg.2022.21271
MLA	ONLEN YÜSÜF,Bal Tayibe,çabalak mehmet,Oztoprak Nefise,Didem sarı Nagehan,Kurtaran Behice,Şenateş Ebubekir,Gunduz Alper,zerdali esra,KARSEN HASAN,Batirel Ayse,KARAALİ Rıdvan,GÜNER RAHMET,Yamazhan Tansu,köse şükran,Erben Nurettin,Ince Nevin,Koksal Iftihar,Sarıgül Figen,Yörük Gülşen,komur suheyla,Kaya Sibel,Esen Şaban,Gunal Ozgur,YILDIZ ILKNUR ESEN,İNAN DİLARA,Barut Sener,NAMIDURU Mustafa,Tosun Selma,Türker Kamuran,Sener Alper,hizel kenan,Baykam Nurcan,Duygu Fazilet,Akıncı Esragül,Can Güray,User Ulku,GÜL Hanefi Cem,AKBULUT AYHAN,Celebi Guven,Sunnetcioglu Mahmut,KARABAY OĞUZ,kumbasar karaosmanoglu hayat,SIRMATEL FATMA,Tabak Fehmi Efficacy and Safety of Direct-Acting Antivirals in Elderly Patients with Chronic Hepatitis C: A Nationwide Real-Life, Observational, Multicenter Study from Turkey. Turkish Journal of Gastroenterology, vol.33, no.10, 2022, ss.862 - 873. 10.5152/tjg.2022.21271
AMA	ONLEN Y,Bal T,çabalak m,Oztoprak N,Didem sarı N,Kurtaran B,Şenateş E,Gunduz A,zerdali e,KARSEN H,Batirel A,KARAALİ R,GÜNER R,Yamazhan T,köse ş,Erben N,Ince N,Koksal I,Sarıgül F,Yörük G,komur s,Kaya S,Esen Ş,Gunal O,YILDIZ I,İNAN D,Barut S,NAMIDURU M,Tosun S,Türker K,Sener A,hizel k,Baykam N,Duygu F,Akıncı E,Can G,User U,GÜL H,AKBULUT A,Celebi G,Sunnetcioglu M,KARABAY O,kumbasar karaosmanoglu h,SIRMATEL F,Tabak F Efficacy and Safety of Direct-Acting Antivirals in Elderly Patients with Chronic Hepatitis C: A Nationwide Real-Life, Observational, Multicenter Study from Turkey. Turkish Journal of Gastroenterology. 2022; 33(10): 862 - 873. 10.5152/tjg.2022.21271
Vancouver	ONLEN Y,Bal T,çabalak m,Oztoprak N,Didem sarı N,Kurtaran B,Şenateş E,Gunduz A,zerdali e,KARSEN H,Batirel A,KARAALİ R,GÜNER R,Yamazhan T,köse ş,Erben N,Ince N,Koksal I,Sarıgül F,Yörük G,komur s,Kaya S,Esen Ş,Gunal O,YILDIZ I,İNAN D,Barut S,NAMIDURU M,Tosun S,Türker K,Sener A,hizel k,Baykam N,Duygu F,Akıncı E,Can G,User U,GÜL H,AKBULUT A,Celebi G,Sunnetcioglu M,KARABAY O,kumbasar karaosmanoglu h,SIRMATEL F,Tabak F Efficacy and Safety of Direct-Acting Antivirals in Elderly Patients with Chronic Hepatitis C: A Nationwide Real-Life, Observational, Multicenter Study from Turkey. Turkish Journal of Gastroenterology. 2022; 33(10): 862 - 873. 10.5152/tjg.2022.21271
IEEE	ONLEN Y,Bal T,çabalak m,Oztoprak N,Didem sarı N,Kurtaran B,Şenateş E,Gunduz A,zerdali e,KARSEN H,Batirel A,KARAALİ R,GÜNER R,Yamazhan T,köse ş,Erben N,Ince N,Koksal I,Sarıgül F,Yörük G,komur s,Kaya S,Esen Ş,Gunal O,YILDIZ I,İNAN D,Barut S,NAMIDURU M,Tosun S,Türker K,Sener A,hizel k,Baykam N,Duygu F,Akıncı E,Can G,User U,GÜL H,AKBULUT A,Celebi G,Sunnetcioglu M,KARABAY O,kumbasar karaosmanoglu h,SIRMATEL F,Tabak F "Efficacy and Safety of Direct-Acting Antivirals in Elderly Patients with Chronic Hepatitis C: A Nationwide Real-Life, Observational, Multicenter Study from Turkey." Turkish Journal of Gastroenterology, 33, ss.862 - 873, 2022. 10.5152/tjg.2022.21271
ISNAD	ONLEN, YÜSÜF vd. "Efficacy and Safety of Direct-Acting Antivirals in Elderly Patients with Chronic Hepatitis C: A Nationwide Real-Life, Observational, Multicenter Study from Turkey". Turkish Journal of Gastroenterology 33/10 (2022), 862-873. https://doi.org/10.5152/tjg.2022.21271