bjective: Purpose of this study the aim of this study is to determine the subjective well-being levels and related factors of in- dividuals diagnosed with multiple sclerosis (MS). Material and Met- hods: The sample of this descriptive study was conducted in a hospital in Samsun province between 01 May-30 June 2019, with 150 individ- uals diagnosed with MS, aged 18-69, reg istered in the neurology out- patient clinic, who met the inclusion criteria of the study. The sample size of the study was determined by the A Priori power analysis of the G* Power 3.1 program. Personal quest ionnaire and Subject ive Well- Being Scale were used to collect data in the study. Data were analyzed with IBM SPSS V23. Independent samples t-test and one-way analy- sis of variance were used to compare normally distributed data accord- ing to demographic characteristics. Subjective Well-Being Scale relia- bility analysis was analyzed using Cronbach alpha. Correlation analy- sis was evaluated w ith Spearman rank correlat ion. Results: The- meanage of individuals diagnosed with MS is 42.1 and 61.3% of them are women. 35.4% of the part icipants are pr imary school graduates, 75.3% are married, 58.7% have the sameincome as their expenses, and 40% have the d isease for more than 11 years. Subject ive Well-Being Scale mean score was determ ined as 166,25±31.78. Scale score aver- ages of those w ith less income and expenses were determ ined as 153.1±34.2, and subjective well-being levels of those with less income than expenses were determined as low. Conclusion: As a result of the study, subjective well-being levels of individuals with MS were found above the average value.