Yıl: 2022 Cilt: 64 Sayı: 1 Sayfa Aralığı: 152 - 159 Metin Dili: İngilizce DOI: 10.24953/turkjped.2020.275 İndeks Tarihi: 15-12-2022

Bladder granulocytic sarcoma in a child: case report and literature review

Öz:
Background. Granulocytic sarcoma (GS) is an extramedullary solid tumor composed of immature myeloid cells. GS has been associated with acute myeloid leukemia (AML), myelodysplastic syndromes or myeloproliferative diseases. Although GS can affect various tissues of the human body, it has rarely been reported in other soft tissues such as the breast, gastrointestinal, respiratory and genitourinary tracts. We report a pediatric case diagnosed with granulocytic sarcoma of the bladder and concomitant AML. Case. A twelve-year-old previously healthy girl was admitted to the pediatric urology clinic with a ten-day history of hematuria and pollakiuria. Laboratory examinations revealed anemia, thrombocytopenia and neutrophilic leukocytosis. Bone marrow aspiration results were consistent with acute myeloid leukemia -FAB subtype M2-. Abdominal magnetic resonance imaging (MRI) showed an irregularly bounded 12 cm mass on the right side of the bladder. Transurethral resection (TUR) pathology was consistent with granulocytic sarcoma. After a multimodal treatment approach, complete remission was achieved. Conclusions. Malignant bladder masses are rare causes of macroscopic hematuria in childhood. The diagnostic spectrum is wide, ranging from rhabdomyosarcoma to leukemia involvement. The bladder is a rare site of extramedullary involvement in pediatric patients with AML. Multimodal treatment should be considered on a per-patient basis.
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  • 1. Kobayashi R, Tawa A, Hanada R, Horibe K, Tsuchida M, Tsukimoto I. Extramedullary infiltration at diagnosis and prognosis in children with acute myelogenous leukemia. Pediatr Blood Cancer 2007; 48: 393-398. https://doi.org/10.1002/pbc.20824
  • 2. Dusenbery KE, Howells WB, Arthur DC, et al. Extramedullary leukemia in children with newly diagnosed acute myeloid leukemia: a report from the Children’s Cancer Group. J Pediatr Hematol Oncol 2003; 25: 760-768. https://doi.org/10.1097/00043426-200310000-00004
  • 3. Johnston DL, Alonzo TA, Gerbing RB, Lange BJ, Woods WG. Superior outcome of pediatric acute myeloid leukemia patients with orbital and CNS myeloid sarcoma: a report from the Children’s Oncology Group. Pediatr Blood Cancer 2012; 58: 519-524. https://doi.org/10.1002/pbc.23201
  • 4. Bekassy AN, Hermans J, Gorin NC, Gratwohl A. Granulocytic sarcoma after allogeneic bone marrow transplantation: a retrospective European multicenter survey. Acute and Chronic Leukemia Working Parties of the European Group for Blood and Marrow Transplantation. Bone Marrow Transplant 1996; 17: 801-808.
  • 5. Merino Moreno J, Nunez Olarte JM, Pico Sambucety JM, Pastor Gomez-Cornejo L, Ortega Nunez A. Granulocytic sarcoma (chloroma) with bladder and breast localizations preceding acute myeloblastic leukemia. Rev Clin Esp 1987; 180: 260-263.
  • 6. Kim LY, Purkey MT, Patel MR, Ghosh A, Hartner L, Newman JG. Primary granulocytic sarcoma of larynx. Head Neck 2015; 37: 38-44. https://doi.org/10.1002/hed.23805
  • 7. Holzwanger EA, Alam Z, Hsu E, Hsu A, Mangano M, Kathman DL. A case of granulocytic sarcoma or extramedullary acute myelomonocytic leukemia of the gallbladder. Am J Case Rep 2018; 19: 1262-1266. https://doi.org/10.12659/AJCR.911390
  • 8. Geok Chin T, Masir N, Noor Hussin H, Mohd Sidik S, Boon Cheok L, Yean T. Myeloid sarcoma of the urinary bladder with cutaneous tumour seeding after percutaneous suprapubic catheterization. Malays J Pathol 2011; 33: 47-51.
  • 9. Gibson BE, Webb DK, Howman AJ, De Graaf SS, Harrison CJ, Wheatley K. Results of a randomized trial in children with Acute Myeloid Leukaemia: medical research council AML12 trial. Br J Haematol 2011; 155: 366-376. https://doi.org/10.1111/j.1365-2141.2011.08851.x
  • 10. Samborska M, Derwich K, Skalska-Sadowska J, Kurzawa P, Wachowiak J. Myeloid sarcoma in children - diagnostic and therapeutic difficulties. Contemporary Oncology 2016; 20: 444-448. https://doi.org/10.5114/wo.2016.65602
  • 11. Wang C, Chen Z, Li Z, Cen J. The essential roles of matrix metalloproteinase-2, membrane type 1 metalloproteinase and tissue inhibitor of metalloproteinase-2 in the invasive capacity of acute monocytic leukemia SHI-1 cells. Leuk Res 2010; 34: 1083-1090. https://doi.org/10.1016/j.leukres.2010.01.016
  • 12. Janowska-Wieczorek A, Marquez LA, Matsuzaki A, et al. Expression of matrix metalloproteinases (MMP- 2 and -9) and tissue inhibitors of metalloproteinases (TIMP-1 and -2) in acute myelogenous leukaemia blasts: comparison with normal bone marrow cells. Br J Haematol 1999; 105: 402-411. https://doi.org/10.1111/j.1365-2141.1999.01352.x
  • 13. Ries C, Loher F, Zang C, Ismair MG, Petrides PE. Matrix metalloproteinase production by bone marrow mononuclear cells from normal individuals and patients with acute and chronic myeloid leukemia or myelodysplastic syndromes. Clin Cancer Res 1999; 5: 1115-1124.
  • 14. Westermarck J, Kahari VM. Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J 1999; 13: 781-792. https://doi.org/10.1096/fasebj.13.8.781
  • 15. Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2002; 2: 161-174. https://doi.org/10.1038/nrc745
  • 16. Li Z, Chen Z, Lu J, et al. Establishment of a nude mice model of human monocytic leukemia with CNS and multiorgan extramedullary infiltration. Eur J Haematol 2006; 77: 128-133. https://doi.org/10.1111/j.1600-0609.2006.00686.x
  • 17. Alexiev BA, Wang W, Ning Y, et al. Myeloid sarcomas: a histologic, immunohistochemical, and cytogenetic study. Diagnostic Pathology 2007; 2: 42. https://doi.org/10.1186/1746-1596-2-42
  • 18. Almond LM, Charalampakis M, Ford SJ, Gourevitch D, Desai A. Myeloid sarcoma: presentation, diagnosis, and treatment. Clin Lymphoma Myeloma Leuk 2017; 17: 263-267. https://doi.org/10.1016/j.clml.2017.02.027
  • 19. Byrd JC, Weiss RB, Arthur DC, et al. Extramedullary leukemia adversely affects hematologic complete remission rate and overall survival in patients with t(8;21)(q22;q22): results from Cancer and Leukemia Group B 8461. J Clin Oncol 1997; 15: 466-475. https://doi.org/10.1200/JCO.1997.15.2.466
  • 20. Stove HK, Sandahl JD, Abrahamsson J, et al. Extramedullary leukemia in children with acute myeloid leukemia: a population-based cohort study from the Nordic Society of Pediatric Hematology and Oncology (NOPHO). Pediatr Blood Cancer 2017; 64: e26520. https://doi.org/10.1002/pbc.26520
  • 21. Cartwright PC, Faye-Petersen O, Bybee B, Snow BW. Leukemic relapse presenting with ureteral obstruction caused by granulocytic sarcoma. J Urol 1991; 146: 1354-1355. https://doi.org/10.1016/S0022-5347(17)38092-8
  • 22. Kaplan J, Dardanelli E, Sierre S, Moguillansky S, Lipsich J. Granulocytic sarcoma of the urinary bladder in a pediatric patient. J Pediatr Urol 2013; 9: 9-11. https://doi.org/10.1016/j.jpurol.2012.04.010
  • 23. Delhi Kumar CG, Thilagavathy V, Arun Babu T. Granulocytic sarcoma of bladder in an 18-mo-old child with acute myeloid leukemia. Indian J Pediatr 2014; 81: 1118-1119. https://doi.org/10.1007/s12098-014-1371-1
  • 24. Anagnostopoulos C, Jadwat Y, Wood NH, et al. A report of oral extramedullary acute myeloid leukaemia (AML) in an 8-year-old girl with newly diagnosed AML-M4Eo. SADJ 2007; 62: 390-393.
  • 25. Siraj F, Kaur M, Dalal V, Khanna A, Khan AA. Myeloid sarcoma: a report of four cases at unusual sites. Ger Med Sci 2017; 15: Doc03. https://doi.org/10.3205/000244
  • 26. Mrad K, Abid L, Driss M, Ben Abid H, Ben Romdhane K. Granulocytic sarcoma of the small intestine in a child without leukemia: report of a case with cytologic findings and immunophenotyping pitfalls. Acta Cytol 2004; 48: 641-644. https://doi.org/10.1159/000326435
  • 27. Lin CH, Wu KH, Lin WC, Tsai JD, Peng CT, Chen AC. Granulocytic sarcoma of the colon in a child with acute myeloid leukemia presenting as hematochezia. J Pediatr Hematol Oncol 2008; 30: 981-983. https://doi.org/10.1097/MPH.0b013e31818c010c
  • 28. Fonseca A, Scheinemann K, Jansen J, Barr R. Testicular myeloid sarcoma: an unusual presentation of infant acute myeloid leukemia. J Pediatr Hematol Oncol 2014; 36: 155-157. https://doi.org/10.1097/MPH.0000000000000097
  • 29. Bakst R, Wolden S, Yahalom J. Radiation therapy for chloroma (granulocytic sarcoma). Int J Radiat Oncol Biol Phys 2012;82:1816-1822. https://doi.org/10.1016/j.ijrobp.2011.02.057
  • 30. Bakst RL, Tallman MS, Douer D, Yahalom J. How I treat extramedullary acute myeloid leukemia. Blood 2011; 118: 3785-3793. https://doi.org/10.1182/blood-2011-04-347229
  • 31. Solh M, Solomon S, Morris L, Holland K, Bashey A. Extramedullary acute myelogenous leukemia. Blood Rev 2016; 30: 333-339. https://doi.org/10.1016/j.blre.2016.04.001
  • 32. Chevallier P, Labopin M, Cornelissen J, Socie G, Rocha V, Mohty M. Allogeneic hematopoietic stem cell transplantation for isolated and leukemic myeloid sarcoma in adults: a report from the Acute Leukemia Working Party of the European group for Blood and Marrow Transplantation. Haematologica 2011; 96: 1391-1394. https://doi.org/10.3324/haematol.2011.041418
  • 33. Gibson BE, Wheatley K, Hann IM, et al. Treatment strategy and long-term results in paediatric patients treated in consecutive UK AML trials. Leukemia 2005; 19: 2130-2138. https://doi.org/10.1038/sj.leu.2403924
  • 34. Rasche M, Steidel E, Kondryn D, et al. Impact of a risk-adapted treatment approach in pediatric AML: a report of the AML-BFM registry 2012. Blood 2019; 134: 293-293. https://doi.org/10.1182/blood-2019-130969
  • 35. Sauer MG, Lang PJ, Albert MH, et al. Hematopoietic stem cell transplantation for children with acute myeloid leukemia-results of the AML SCT-BFM 2007 trial. Leukemia 2020; 34: 613-624. https://doi.org/10.1038/s41375-019-0584-8
  • 36. Kolb EA, Meshinchi S. Acute myeloid leukemia in children and adolescents: identification of new molecular targets brings promise of new therapies. Hematology Am Soc Hematol Educ Program 2015; 2015: 507-513. https://doi.org/10.1182/asheducation-2015.1.507
APA Tuna Deveci R, Karaman S, Oktar T, Anak S, Dogan I, Unuvar A, Tugcu D, Ince bayramoglu z, ÇAKI KILIÇ S, İRİBAŞ ÇELİK A, KARAKAS Z (2022). Bladder granulocytic sarcoma in a child: case report and literature review. , 152 - 159. 10.24953/turkjped.2020.275
Chicago Tuna Deveci Rumeysa,Karaman Serap,Oktar Tayfun,Anak Seniye Sema,Dogan Ibrahim Oner,Unuvar Aysegul,Tugcu Deniz,Ince bayramoglu zuhal,ÇAKI KILIÇ SUAR,İRİBAŞ ÇELİK AYÇA,KARAKAS ZEYNEP Bladder granulocytic sarcoma in a child: case report and literature review. (2022): 152 - 159. 10.24953/turkjped.2020.275
MLA Tuna Deveci Rumeysa,Karaman Serap,Oktar Tayfun,Anak Seniye Sema,Dogan Ibrahim Oner,Unuvar Aysegul,Tugcu Deniz,Ince bayramoglu zuhal,ÇAKI KILIÇ SUAR,İRİBAŞ ÇELİK AYÇA,KARAKAS ZEYNEP Bladder granulocytic sarcoma in a child: case report and literature review. , 2022, ss.152 - 159. 10.24953/turkjped.2020.275
AMA Tuna Deveci R,Karaman S,Oktar T,Anak S,Dogan I,Unuvar A,Tugcu D,Ince bayramoglu z,ÇAKI KILIÇ S,İRİBAŞ ÇELİK A,KARAKAS Z Bladder granulocytic sarcoma in a child: case report and literature review. . 2022; 152 - 159. 10.24953/turkjped.2020.275
Vancouver Tuna Deveci R,Karaman S,Oktar T,Anak S,Dogan I,Unuvar A,Tugcu D,Ince bayramoglu z,ÇAKI KILIÇ S,İRİBAŞ ÇELİK A,KARAKAS Z Bladder granulocytic sarcoma in a child: case report and literature review. . 2022; 152 - 159. 10.24953/turkjped.2020.275
IEEE Tuna Deveci R,Karaman S,Oktar T,Anak S,Dogan I,Unuvar A,Tugcu D,Ince bayramoglu z,ÇAKI KILIÇ S,İRİBAŞ ÇELİK A,KARAKAS Z "Bladder granulocytic sarcoma in a child: case report and literature review." , ss.152 - 159, 2022. 10.24953/turkjped.2020.275
ISNAD Tuna Deveci, Rumeysa vd. "Bladder granulocytic sarcoma in a child: case report and literature review". (2022), 152-159. https://doi.org/10.24953/turkjped.2020.275
APA Tuna Deveci R, Karaman S, Oktar T, Anak S, Dogan I, Unuvar A, Tugcu D, Ince bayramoglu z, ÇAKI KILIÇ S, İRİBAŞ ÇELİK A, KARAKAS Z (2022). Bladder granulocytic sarcoma in a child: case report and literature review. Turkish Journal of Pediatrics, 64(1), 152 - 159. 10.24953/turkjped.2020.275
Chicago Tuna Deveci Rumeysa,Karaman Serap,Oktar Tayfun,Anak Seniye Sema,Dogan Ibrahim Oner,Unuvar Aysegul,Tugcu Deniz,Ince bayramoglu zuhal,ÇAKI KILIÇ SUAR,İRİBAŞ ÇELİK AYÇA,KARAKAS ZEYNEP Bladder granulocytic sarcoma in a child: case report and literature review. Turkish Journal of Pediatrics 64, no.1 (2022): 152 - 159. 10.24953/turkjped.2020.275
MLA Tuna Deveci Rumeysa,Karaman Serap,Oktar Tayfun,Anak Seniye Sema,Dogan Ibrahim Oner,Unuvar Aysegul,Tugcu Deniz,Ince bayramoglu zuhal,ÇAKI KILIÇ SUAR,İRİBAŞ ÇELİK AYÇA,KARAKAS ZEYNEP Bladder granulocytic sarcoma in a child: case report and literature review. Turkish Journal of Pediatrics, vol.64, no.1, 2022, ss.152 - 159. 10.24953/turkjped.2020.275
AMA Tuna Deveci R,Karaman S,Oktar T,Anak S,Dogan I,Unuvar A,Tugcu D,Ince bayramoglu z,ÇAKI KILIÇ S,İRİBAŞ ÇELİK A,KARAKAS Z Bladder granulocytic sarcoma in a child: case report and literature review. Turkish Journal of Pediatrics. 2022; 64(1): 152 - 159. 10.24953/turkjped.2020.275
Vancouver Tuna Deveci R,Karaman S,Oktar T,Anak S,Dogan I,Unuvar A,Tugcu D,Ince bayramoglu z,ÇAKI KILIÇ S,İRİBAŞ ÇELİK A,KARAKAS Z Bladder granulocytic sarcoma in a child: case report and literature review. Turkish Journal of Pediatrics. 2022; 64(1): 152 - 159. 10.24953/turkjped.2020.275
IEEE Tuna Deveci R,Karaman S,Oktar T,Anak S,Dogan I,Unuvar A,Tugcu D,Ince bayramoglu z,ÇAKI KILIÇ S,İRİBAŞ ÇELİK A,KARAKAS Z "Bladder granulocytic sarcoma in a child: case report and literature review." Turkish Journal of Pediatrics, 64, ss.152 - 159, 2022. 10.24953/turkjped.2020.275
ISNAD Tuna Deveci, Rumeysa vd. "Bladder granulocytic sarcoma in a child: case report and literature review". Turkish Journal of Pediatrics 64/1 (2022), 152-159. https://doi.org/10.24953/turkjped.2020.275