Objective: The aim of this study was to determine the prevalence of depression and related factors in 18-49 aged women registered in a family health center in Istanbul. Method: This descriptive study was carried out in a family health center in Maltepe, Istanbul. Data were collected using a questionnaire developed by the researcher and the Beck Depression Scale. P value was taken as 0,05. Results: A total of 260 women were included in the study. The average age of the participants was 31,2±9,9 years. According to the Beck Depression Scale, 28.7% (n=74) of the participants had moderate and 7.7% (n=20) had severe depression. A significant difference was found between the presence of depression and monthly income (p=0,010), marital status (p=0,018), cigarette (p=0,002) and alcohol (p=0,005) use. Moderate and severe depression increases in participants who have been subjected to physical or psychological violence during childhood (p=0,003). The current exposure to physical and psychological violence was found to be similarly significant (p=0,000). Conclusion: In this study, the frequency of depression in women between the ages of 18-49 was found to be 36,4%. Periodic screening of women of reproductive age registered with family health centers, especially risk groups, may be useful in combating depression.