The Effects of Myricetin Against Testicular and Lung Injury Induced by Testicular Ischemia Reperfusion Model

guler, mustafa can; tanyeli, ayhan; Güzel Erdoğan, Derya; Öztürk, Deniz; Baylan, Hüseyin; Eraslan, Ersen

doi:10.31832/smj.783480

The Effects of Myricetin Against Testicular and Lung Injury Induced by Testicular Ischemia Reperfusion Model

Deniz ÖZTÜRK, (Atatürk Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler/Diyaliz, Erzurum, Türkiye)

Ayhan TANYELİ, (Atatürk Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Erzurum, Türkiye)

Derya GÜZEL ERDOĞAN, (Sakarya Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Sakarya, Türkiye)

Mustafa Can GÜLER, (Atatürk Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Erzurum, Türkiye)

Ersen ERASLAN, (Yozgat Bozok Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Yozgat, Türkiye)

Hüseyin BAYLAN (Sakarya Üniversitesi, Tıp Fakültesi, Anatomi Anabilim Dalı, Sakarya, Türkiye)

Sakarya Tıp Dergisi

5 1

Yıl: 2021 Cilt: 11 Sayı: 1 Sayfa Aralığı: 109 - 114 Metin Dili: İngilizce DOI: 10.31832/smj.783480 İndeks Tarihi: 05-12-2022

The Effects of Myricetin Against Testicular and Lung Injury Induced by Testicular Ischemia Reperfusion Model

Öz:

Objective: Testicular torsion may lead to testicular atrophy and male infertility if untreated within some hours. Since ischemia reperfusion (I/R) injury is a reason for the harmful effects during testicular torsion, antioxidant agents are among the targets of science to deal with reactive oxygen species (ROS). As a flavonoid member, myricetin (3, 3, 4, 5, 5, 7-hexahydroxyflavone, MYR) has antioxidant, anticancer, anti-inflammatory, antiviral, and antidiabetic activities. Materials and Methods: In this experiment 32 Wistar albino male rats were randomly divided into 4 groups (n=8). Group I was defined as the sham group. In group II, I/R group, testicular torsion detorsion was performed. In group III (MYR 25) and group IV (MYR 50), MYR was administrated intraperitoneally at 25 and 50 mg/kg doses, 30 minutes before detorsion. The testicular and lung tissue samples were examined biochemically. Results: In both testis and lung tissues, MYR decreased TOS, MDA, and MPO levels at both high and low doses compared to the I/R group. Besides, SOD values increased in MYR treatment groups compared to the I/R group. Conclusion: MYR performed promising effects on testicular and lung tissues following testicular I/R injury according to biochemical parameters.

Anahtar Kelime: myricetin torsion detorsion ischemia reperfusion testis lung

Mirisetinin Testiküler İskemi Reperfüzyon ile İndüklenen Testis ve Akciğer Hasarına Karşı Etkileri

Öz:

Amaç: Testis torsiyonu birkaç saat içinde tedavi edilmezse erkeklerde testis atrofisine ve kısırlığa neden olabilir. Antioksidan ajanlar testis torsiyonu ile baş etmede hedefler arasındadır. Mirisetin (myricetin, 3, 3, 4, 5, 5, 7-hekzahidroksiflavon, MYR), antioksidan, antikanser, anti-inflamatuar, antiviral ve antidiyabetik aktivitelere sahiptir. Gereç ve Yöntemler: 32 adet Wistar albino erkek sıçan rastgele 4 gruba (n=8) ayrıldı. Grup I sham grup olarak tanımlandı. Grup II, I/R grubunda testis torsiyonu yapıldı. Grup III (MYR 25) ve grup IV'te (MYR 50), detorsiyondan 30 dakika önce 25 ve 50 mg/kg dozlarda MYR intraperitoneal olarak uygulandı. Testis ve akciğer doku örnekleri biyokimyasal olarak incelendi. Bulgular: Testis ve akciğer dokularında MYR, I/R grubuna kıyasla hem yüksek hem de düşük dozlarda TOS, MPO ve MDA seviyelerini azaltmıştır. Ayrıca MYR uygulanan gruplarda I/R grubuna kıyasla SOD değerleri artmıştır. Sonuç: Biyokimyasal parametreler değerlendirildiğinde, MYR testis I/R hasarını takiben testis ve akciğer dokuları üzerinde olumlu etkiler gösterdi.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Öztürk D, tanyeli a, Güzel Erdoğan D, guler m, Eraslan E, Baylan H (2021). The Effects of Myricetin Against Testicular and Lung Injury Induced by Testicular Ischemia Reperfusion Model. , 109 - 114. 10.31832/smj.783480
Chicago	Öztürk Deniz,tanyeli ayhan,Güzel Erdoğan Derya,guler mustafa can,Eraslan Ersen,Baylan Hüseyin The Effects of Myricetin Against Testicular and Lung Injury Induced by Testicular Ischemia Reperfusion Model. (2021): 109 - 114. 10.31832/smj.783480
MLA	Öztürk Deniz,tanyeli ayhan,Güzel Erdoğan Derya,guler mustafa can,Eraslan Ersen,Baylan Hüseyin The Effects of Myricetin Against Testicular and Lung Injury Induced by Testicular Ischemia Reperfusion Model. , 2021, ss.109 - 114. 10.31832/smj.783480
AMA	Öztürk D,tanyeli a,Güzel Erdoğan D,guler m,Eraslan E,Baylan H The Effects of Myricetin Against Testicular and Lung Injury Induced by Testicular Ischemia Reperfusion Model. . 2021; 109 - 114. 10.31832/smj.783480
Vancouver	Öztürk D,tanyeli a,Güzel Erdoğan D,guler m,Eraslan E,Baylan H The Effects of Myricetin Against Testicular and Lung Injury Induced by Testicular Ischemia Reperfusion Model. . 2021; 109 - 114. 10.31832/smj.783480
IEEE	Öztürk D,tanyeli a,Güzel Erdoğan D,guler m,Eraslan E,Baylan H "The Effects of Myricetin Against Testicular and Lung Injury Induced by Testicular Ischemia Reperfusion Model." , ss.109 - 114, 2021. 10.31832/smj.783480
ISNAD	Öztürk, Deniz vd. "The Effects of Myricetin Against Testicular and Lung Injury Induced by Testicular Ischemia Reperfusion Model". (2021), 109-114. https://doi.org/10.31832/smj.783480

APA	Öztürk D, tanyeli a, Güzel Erdoğan D, guler m, Eraslan E, Baylan H (2021). The Effects of Myricetin Against Testicular and Lung Injury Induced by Testicular Ischemia Reperfusion Model. Sakarya Tıp Dergisi, 11(1), 109 - 114. 10.31832/smj.783480
Chicago	Öztürk Deniz,tanyeli ayhan,Güzel Erdoğan Derya,guler mustafa can,Eraslan Ersen,Baylan Hüseyin The Effects of Myricetin Against Testicular and Lung Injury Induced by Testicular Ischemia Reperfusion Model. Sakarya Tıp Dergisi 11, no.1 (2021): 109 - 114. 10.31832/smj.783480
MLA	Öztürk Deniz,tanyeli ayhan,Güzel Erdoğan Derya,guler mustafa can,Eraslan Ersen,Baylan Hüseyin The Effects of Myricetin Against Testicular and Lung Injury Induced by Testicular Ischemia Reperfusion Model. Sakarya Tıp Dergisi, vol.11, no.1, 2021, ss.109 - 114. 10.31832/smj.783480
AMA	Öztürk D,tanyeli a,Güzel Erdoğan D,guler m,Eraslan E,Baylan H The Effects of Myricetin Against Testicular and Lung Injury Induced by Testicular Ischemia Reperfusion Model. Sakarya Tıp Dergisi. 2021; 11(1): 109 - 114. 10.31832/smj.783480
Vancouver	Öztürk D,tanyeli a,Güzel Erdoğan D,guler m,Eraslan E,Baylan H The Effects of Myricetin Against Testicular and Lung Injury Induced by Testicular Ischemia Reperfusion Model. Sakarya Tıp Dergisi. 2021; 11(1): 109 - 114. 10.31832/smj.783480
IEEE	Öztürk D,tanyeli a,Güzel Erdoğan D,guler m,Eraslan E,Baylan H "The Effects of Myricetin Against Testicular and Lung Injury Induced by Testicular Ischemia Reperfusion Model." Sakarya Tıp Dergisi, 11, ss.109 - 114, 2021. 10.31832/smj.783480
ISNAD	Öztürk, Deniz vd. "The Effects of Myricetin Against Testicular and Lung Injury Induced by Testicular Ischemia Reperfusion Model". Sakarya Tıp Dergisi 11/1 (2021), 109-114. https://doi.org/10.31832/smj.783480