Comprehensive evaluation of Reseda lutea L. (Wild Mignonette) and 7 isolated flavonol glycosides: determination of antioxidant activity, anti-Alzheimer, antidiabetic and cytotoxic effects with in vitro and in silico methods
Yıl: 2022 Cilt: 46 Sayı: 4 Sayfa Aralığı: 1185 - 1198 Metin Dili: İngilizce DOI: 10.55730/1300-0527.3426 İndeks Tarihi: 06-12-2022
Comprehensive evaluation of Reseda lutea L. (Wild Mignonette) and 7 isolated flavonol glycosides: determination of antioxidant activity, anti-Alzheimer, antidiabetic and cytotoxic effects with in vitro and in silico methods
Öz: In this study, anticholinergic, antidiabetic, antioxidant and cytotoxic activities of Reseda lutea L. (R. lutea) were determined. Ethanol extracts of R. lutea (EERL) and water extract of R. lutea (WERL) were prepared for biochemical analysis. The antioxidant capacities of EERL and WERL were evaluated with 6 different methods. In addition, acetylcholinesterase (AChE), α-amylase and α-glycosidase enzyme inhibition by EERL were measured. According to the results, EERL exhibited high inhibition effects against α-amylase, α-glycosidase and AChE enzymes. The $IC_{50}$ values of EERL against AChE (2.21 μg/mL), α-glycosidase (1.38 μg/mL), and α-amylase (0.11 μg/mL) were determined. Also, high cytotoxic effect of EERL was observed on human lung cancer cell lines (A549) with an $IC_{50}$ value of 3.58 ± 1.10 μg/mL. The affinities of 7 kaempferol and isorhamnetin rhamnopyranoside molecules, previously isolated from R. lutea, for AChE, α-amylase and, α-glycosidase were determined by molecular docking studies. Molecular docking results supported the in vitro results of the study. The results showed that the aerial parts of R. lutea have effective antioxidant, anticholinergic, antidiabetic and cytotoxic activities. This research will form the basis for further studies about R. lutea usage for drug development.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | kızıltaş h (2022). Comprehensive evaluation of Reseda lutea L. (Wild Mignonette) and 7 isolated flavonol glycosides: determination of antioxidant activity, anti-Alzheimer, antidiabetic and cytotoxic effects with in vitro and in silico methods. , 1185 - 1198. 10.55730/1300-0527.3426 |
| Chicago | kızıltaş hatice Comprehensive evaluation of Reseda lutea L. (Wild Mignonette) and 7 isolated flavonol glycosides: determination of antioxidant activity, anti-Alzheimer, antidiabetic and cytotoxic effects with in vitro and in silico methods. (2022): 1185 - 1198. 10.55730/1300-0527.3426 |
| MLA | kızıltaş hatice Comprehensive evaluation of Reseda lutea L. (Wild Mignonette) and 7 isolated flavonol glycosides: determination of antioxidant activity, anti-Alzheimer, antidiabetic and cytotoxic effects with in vitro and in silico methods. , 2022, ss.1185 - 1198. 10.55730/1300-0527.3426 |
| AMA | kızıltaş h Comprehensive evaluation of Reseda lutea L. (Wild Mignonette) and 7 isolated flavonol glycosides: determination of antioxidant activity, anti-Alzheimer, antidiabetic and cytotoxic effects with in vitro and in silico methods. . 2022; 1185 - 1198. 10.55730/1300-0527.3426 |
| Vancouver | kızıltaş h Comprehensive evaluation of Reseda lutea L. (Wild Mignonette) and 7 isolated flavonol glycosides: determination of antioxidant activity, anti-Alzheimer, antidiabetic and cytotoxic effects with in vitro and in silico methods. . 2022; 1185 - 1198. 10.55730/1300-0527.3426 |
| IEEE | kızıltaş h "Comprehensive evaluation of Reseda lutea L. (Wild Mignonette) and 7 isolated flavonol glycosides: determination of antioxidant activity, anti-Alzheimer, antidiabetic and cytotoxic effects with in vitro and in silico methods." , ss.1185 - 1198, 2022. 10.55730/1300-0527.3426 |
| ISNAD | kızıltaş, hatice. "Comprehensive evaluation of Reseda lutea L. (Wild Mignonette) and 7 isolated flavonol glycosides: determination of antioxidant activity, anti-Alzheimer, antidiabetic and cytotoxic effects with in vitro and in silico methods". (2022), 1185-1198. https://doi.org/10.55730/1300-0527.3426 |
| APA | kızıltaş h (2022). Comprehensive evaluation of Reseda lutea L. (Wild Mignonette) and 7 isolated flavonol glycosides: determination of antioxidant activity, anti-Alzheimer, antidiabetic and cytotoxic effects with in vitro and in silico methods. Turkish Journal of Chemistry, 46(4), 1185 - 1198. 10.55730/1300-0527.3426 |
| Chicago | kızıltaş hatice Comprehensive evaluation of Reseda lutea L. (Wild Mignonette) and 7 isolated flavonol glycosides: determination of antioxidant activity, anti-Alzheimer, antidiabetic and cytotoxic effects with in vitro and in silico methods. Turkish Journal of Chemistry 46, no.4 (2022): 1185 - 1198. 10.55730/1300-0527.3426 |
| MLA | kızıltaş hatice Comprehensive evaluation of Reseda lutea L. (Wild Mignonette) and 7 isolated flavonol glycosides: determination of antioxidant activity, anti-Alzheimer, antidiabetic and cytotoxic effects with in vitro and in silico methods. Turkish Journal of Chemistry, vol.46, no.4, 2022, ss.1185 - 1198. 10.55730/1300-0527.3426 |
| AMA | kızıltaş h Comprehensive evaluation of Reseda lutea L. (Wild Mignonette) and 7 isolated flavonol glycosides: determination of antioxidant activity, anti-Alzheimer, antidiabetic and cytotoxic effects with in vitro and in silico methods. Turkish Journal of Chemistry. 2022; 46(4): 1185 - 1198. 10.55730/1300-0527.3426 |
| Vancouver | kızıltaş h Comprehensive evaluation of Reseda lutea L. (Wild Mignonette) and 7 isolated flavonol glycosides: determination of antioxidant activity, anti-Alzheimer, antidiabetic and cytotoxic effects with in vitro and in silico methods. Turkish Journal of Chemistry. 2022; 46(4): 1185 - 1198. 10.55730/1300-0527.3426 |
| IEEE | kızıltaş h "Comprehensive evaluation of Reseda lutea L. (Wild Mignonette) and 7 isolated flavonol glycosides: determination of antioxidant activity, anti-Alzheimer, antidiabetic and cytotoxic effects with in vitro and in silico methods." Turkish Journal of Chemistry, 46, ss.1185 - 1198, 2022. 10.55730/1300-0527.3426 |
| ISNAD | kızıltaş, hatice. "Comprehensive evaluation of Reseda lutea L. (Wild Mignonette) and 7 isolated flavonol glycosides: determination of antioxidant activity, anti-Alzheimer, antidiabetic and cytotoxic effects with in vitro and in silico methods". Turkish Journal of Chemistry 46/4 (2022), 1185-1198. https://doi.org/10.55730/1300-0527.3426 |
