Synthesis and antioxidant activities of benzylic bromophenols inclusive of natural products

Üç, Eda Mehtap; Gulcin, ilhami; Rezaei, Mohsen; Menzek, Abdullah; bayrak, çetin

doi:10.55730/1300-0527.3447

Synthesis and antioxidant activities of benzylic bromophenols inclusive of natural products

Çetin BAYRAK, (Atatürk Üniversitesi, Fen Fakültesi, Kimya Bölümü, Erzurum, Türkiye)

Eda Mehtap ÜÇ, (Atatürk Üniversitesi, Fen Fakültesi, Kimya Bölümü, Erzurum, Türkiye)

Mohsen Rezaei, (Atatürk Üniversitesi, Fen Fakültesi, Kimya Bölümü, Erzurum, Türkiye)

İlhami GÜLÇİN, (Atatürk Üniversitesi, Fen Fakültesi, Kimya Bölümü, Erzurum, Türkiye)

Abdullah MENZEK (Atatürk Üniversitesi, Fen Fakültesi, Kimya Bölümü, Erzurum, Türkiye)

Turkish Journal of Chemistry

3 0

Yıl: 2022 Cilt: 46 Sayı: 5 Sayfa Aralığı: 1405 - 1416 Metin Dili: İngilizce DOI: 10.55730/1300-0527.3447 İndeks Tarihi: 06-12-2022

Synthesis and antioxidant activities of benzylic bromophenols inclusive of natural products

Öz:

The synthesis of natural products 2-(2,3-dibromo-4,5-dihydroxyphenyl)acetic acid ( 1) and 2-(2,6-dibromo-3,5- dihydroxyphenyl)acetic acid (2) and as well as their derivatives 25 and 26 were carried out by substitution, hydrolysis and demethylation reactions of the corresponding four benzyl bromides. The antioxidant potentials of benzylic acid-derived bromophenols were, for the first time, appraised by several outstanding bioanalytical methods. Besides these, we estimated the antioxidant effects which were studied using the methods of DPPH·, $ABTS^{•+}$ scavenging activities, ferric $(Fe^{3+})$ and cupric $(Cu^{2+})$ ions and Fe3+-TPTZ reducing capacities. Benzylic acid-derived bromophenols were found as effective DPPH•, and $ABTS^{•+}$ scavengers. The potential antioxidant activities of bromophenol derivatives 1, 2 and 17–28 were compared to standard antioxidants including BHA, BHT, α-Tocopherol, and Trolox, which is a water soluble analog of vitamin E. We expect that this innovative work will direct future studies exploring the antioxidant properties of food, medicinal, and industrial applications.

Anahtar Kelime: Antioxidant activity bromination bromophenol radical scavenging natural product benzylic acid

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	bayrak ç, Üç E, Rezaei M, Gulcin i, Menzek A (2022). Synthesis and antioxidant activities of benzylic bromophenols inclusive of natural products. , 1405 - 1416. 10.55730/1300-0527.3447
Chicago	bayrak çetin,Üç Eda Mehtap,Rezaei Mohsen,Gulcin ilhami,Menzek Abdullah Synthesis and antioxidant activities of benzylic bromophenols inclusive of natural products. (2022): 1405 - 1416. 10.55730/1300-0527.3447
MLA	bayrak çetin,Üç Eda Mehtap,Rezaei Mohsen,Gulcin ilhami,Menzek Abdullah Synthesis and antioxidant activities of benzylic bromophenols inclusive of natural products. , 2022, ss.1405 - 1416. 10.55730/1300-0527.3447
AMA	bayrak ç,Üç E,Rezaei M,Gulcin i,Menzek A Synthesis and antioxidant activities of benzylic bromophenols inclusive of natural products. . 2022; 1405 - 1416. 10.55730/1300-0527.3447
Vancouver	bayrak ç,Üç E,Rezaei M,Gulcin i,Menzek A Synthesis and antioxidant activities of benzylic bromophenols inclusive of natural products. . 2022; 1405 - 1416. 10.55730/1300-0527.3447
IEEE	bayrak ç,Üç E,Rezaei M,Gulcin i,Menzek A "Synthesis and antioxidant activities of benzylic bromophenols inclusive of natural products." , ss.1405 - 1416, 2022. 10.55730/1300-0527.3447
ISNAD	bayrak, çetin vd. "Synthesis and antioxidant activities of benzylic bromophenols inclusive of natural products". (2022), 1405-1416. https://doi.org/10.55730/1300-0527.3447

APA	bayrak ç, Üç E, Rezaei M, Gulcin i, Menzek A (2022). Synthesis and antioxidant activities of benzylic bromophenols inclusive of natural products. Turkish Journal of Chemistry, 46(5), 1405 - 1416. 10.55730/1300-0527.3447
Chicago	bayrak çetin,Üç Eda Mehtap,Rezaei Mohsen,Gulcin ilhami,Menzek Abdullah Synthesis and antioxidant activities of benzylic bromophenols inclusive of natural products. Turkish Journal of Chemistry 46, no.5 (2022): 1405 - 1416. 10.55730/1300-0527.3447
MLA	bayrak çetin,Üç Eda Mehtap,Rezaei Mohsen,Gulcin ilhami,Menzek Abdullah Synthesis and antioxidant activities of benzylic bromophenols inclusive of natural products. Turkish Journal of Chemistry, vol.46, no.5, 2022, ss.1405 - 1416. 10.55730/1300-0527.3447
AMA	bayrak ç,Üç E,Rezaei M,Gulcin i,Menzek A Synthesis and antioxidant activities of benzylic bromophenols inclusive of natural products. Turkish Journal of Chemistry. 2022; 46(5): 1405 - 1416. 10.55730/1300-0527.3447
Vancouver	bayrak ç,Üç E,Rezaei M,Gulcin i,Menzek A Synthesis and antioxidant activities of benzylic bromophenols inclusive of natural products. Turkish Journal of Chemistry. 2022; 46(5): 1405 - 1416. 10.55730/1300-0527.3447
IEEE	bayrak ç,Üç E,Rezaei M,Gulcin i,Menzek A "Synthesis and antioxidant activities of benzylic bromophenols inclusive of natural products." Turkish Journal of Chemistry, 46, ss.1405 - 1416, 2022. 10.55730/1300-0527.3447
ISNAD	bayrak, çetin vd. "Synthesis and antioxidant activities of benzylic bromophenols inclusive of natural products". Turkish Journal of Chemistry 46/5 (2022), 1405-1416. https://doi.org/10.55730/1300-0527.3447