Objective: Heart failure (HF) is characterized by chronic, progressive impairment of cardiac functions and is associated with high mortality and morbidity. Psychological symptoms such as depression and anxiety are common among patients with HF and related to mortality, poor function, and treatment adherence failure. In this study we aimed to screen the depression and anxiety symptoms among patients with HF.Materials and methods: In this cross-sectional, observational study, the Hospital Anxiety and Depression Scale (HAD) was used. A total number of 140 patients diagnosed with HF (94 male, 46 female) under follow-up for at least one year were enrolled into study. Statistical analyses were performed using SPSS.Results: The mean depression score was 9.5±3.9, and the mean anxiety score was 8.9±4.1. According to the cut-off scores, 74% of the patients had depressive symptoms, whereas 39% of the patients regarded as having anxiety symptoms. The depression and anxiety scores were significantly higher in NYHA Class 3-4 patients compared with those in NYHA Class 1-2. There is positive correlation between duration of disease and depression scores. Patients sleeping less than 6 hours had higher level of depression and anxiety scores.Conclusion: The present study provides evidence of high prevalence rates of depression and anxiety symptoms in patients with HF. This study might guide us to psychological or medical treatment for psychological disorders among patients with HF.