Relationship of HLA-B alleles on susceptibility to and  protection from HIV infection in Turkish population

İNAN, DİLARA; KILINÇ, YAHYA; Arslan, Habibe Sema; UÇAR, Fahri; Sayın EKİNCİ, Nurten; boylubay, özaydın; Darbas, Sule; KOKSOY, SADI; Mutlu, Esvet; YUCEL, Burcu

doi:10.14744/nci.2021.00018

Relationship of HLA-B alleles on susceptibility to and protection from HIV infection in Turkish population

Şule DARDAŞ, (Akdeniz Üniversitesi ,Tıp Fakültesi, Tıbbi Biyoloji ve Genetik Anabilim Dalı, Antalya, Türkiye)

Yahya KILINÇ, (Akdeniz Üniversitesi ,Tıp Fakültesi, Tıbbi Biyoloji ve Genetik Anabilim Dalı, Antalya, Türkiye)

Habibe Sema ARSLAN, (Akdeniz Üniversitesi ,Tıp Fakültesi, Tıbbi Biyoloji ve Genetik Anabilim Dalı, Antalya, Türkiye)

Dilara İNAN, (Akdeniz Üniversitesi, Tıp Fakültesi, Enfeksiyon Hastalıkları Anabilim Dalı, Antalya, Türkiye)

Fahri UÇAR, (Akdeniz Üniversitesi ,Tıp Fakültesi, Tıbbi Biyoloji ve Genetik Anabilim Dalı, Antalya, Türkiye)

özaydın boylubay, (Isparta İl Sağlık Müdürlüğü, Merkez Toplum Sağlığı Merkezi, Isparta, Türkiye)

SADİ KÖKSOY, (Akdeniz Üniversitesi, Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Antalya, Türkiye)

Esvet MUTLU, (Akdeniz Üniversitesi, Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Antalya, Türkiye)

Burcu YUCEL, (İstanbul Medeniyet Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, İstanbul, Türkiye)

Nurten SAYIN EKİNCİ (Akdeniz Üniversitesi ,Tıp Fakültesi, Tıbbi Biyoloji ve Genetik Anabilim Dalı, Antalya, Türkiye)

İstanbul Kuzey Klinikleri

13 2

Yıl: 2023 Cilt: 10 Sayı: 1 Sayfa Aralığı: 67 - 73 Metin Dili: İngilizce DOI: 10.14744/nci.2021.00018 İndeks Tarihi: 03-05-2023

Relationship of HLA-B alleles on susceptibility to and protection from HIV infection in Turkish population

Öz:

OBJECTIVE: Many human leukocyte antigen (HLA)-B alleles are associated with an increased risk of Acquired Immune Defi ciency Syndrome (AIDS) and Human Immunodeficiency Virus (HIV) progression; however, their distribution varies among dif ferent racial/ethnic groups. Abacavir used in the treatment of AIDS significantly increases the risk of hypersensitivity reactions in patients with HLA-B*57:01. The aim of this study was to determine the distribution of HIV-associated HLA-B subgroups (high and low resolution) and HLA-B*57:01 associated with Abacavir sensitivity in Turkiye. METHODS: This retrospective case-control study consisted of 416 (F/M:111/305) HIV positive patients and 416 (F/M:111/305) healthy controls. HLA-B alleles were identified using Luminex based low-resolution method and further subgrouped by se quence-based high-resolution typing. RESULTS: Our data showed that in patients with HIV-1 infection, HLA-B*15, *35, and *51 allele frequencies were high er, while the HLA-B*07, *14 and *55 allele frequencies were lower as compared to the controls. It was determined that HLA-B*15:01, *35:01, *35:08, and *51:01 alleles frequencies were higher in the patients with HIV-1 infection compared to the controls as HLA-B*07:02, *14:01, *44:01, and *55:01 allele frequencies were detected low. HLA-B*57:01 allele positivity, which is important in Abacavir hypersensitivity, was lower than controls, and this difference was not statistically significant. CONCLUSION: Our results suggest that, HLA-B*07, *14, and *55 alleles and HLA-B*07:02, *14:01, *44:01, and *55:01 subgroups might have a protective effect, while HLA-B*15, *35, and *51 alleles and HLA-B*15:01, *35:01, *35:08, and *51:01 subgroups might play a role in susceptibility to HIV-1 infection.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Darbas S, KILINÇ Y, Arslan H, İNAN D, UÇAR F, boylubay ö, KOKSOY S, Mutlu E, YUCEL B, Sayın EKİNCİ N (2023). Relationship of HLA-B alleles on susceptibility to and protection from HIV infection in Turkish population. , 67 - 73. 10.14744/nci.2021.00018
Chicago	Darbas Sule,KILINÇ YAHYA,Arslan Habibe Sema,İNAN DİLARA,UÇAR Fahri,boylubay özaydın,KOKSOY SADI,Mutlu Esvet,YUCEL Burcu,Sayın EKİNCİ Nurten Relationship of HLA-B alleles on susceptibility to and protection from HIV infection in Turkish population. (2023): 67 - 73. 10.14744/nci.2021.00018
MLA	Darbas Sule,KILINÇ YAHYA,Arslan Habibe Sema,İNAN DİLARA,UÇAR Fahri,boylubay özaydın,KOKSOY SADI,Mutlu Esvet,YUCEL Burcu,Sayın EKİNCİ Nurten Relationship of HLA-B alleles on susceptibility to and protection from HIV infection in Turkish population. , 2023, ss.67 - 73. 10.14744/nci.2021.00018
AMA	Darbas S,KILINÇ Y,Arslan H,İNAN D,UÇAR F,boylubay ö,KOKSOY S,Mutlu E,YUCEL B,Sayın EKİNCİ N Relationship of HLA-B alleles on susceptibility to and protection from HIV infection in Turkish population. . 2023; 67 - 73. 10.14744/nci.2021.00018
Vancouver	Darbas S,KILINÇ Y,Arslan H,İNAN D,UÇAR F,boylubay ö,KOKSOY S,Mutlu E,YUCEL B,Sayın EKİNCİ N Relationship of HLA-B alleles on susceptibility to and protection from HIV infection in Turkish population. . 2023; 67 - 73. 10.14744/nci.2021.00018
IEEE	Darbas S,KILINÇ Y,Arslan H,İNAN D,UÇAR F,boylubay ö,KOKSOY S,Mutlu E,YUCEL B,Sayın EKİNCİ N "Relationship of HLA-B alleles on susceptibility to and protection from HIV infection in Turkish population." , ss.67 - 73, 2023. 10.14744/nci.2021.00018
ISNAD	Darbas, Sule vd. "Relationship of HLA-B alleles on susceptibility to and protection from HIV infection in Turkish population". (2023), 67-73. https://doi.org/10.14744/nci.2021.00018

APA	Darbas S, KILINÇ Y, Arslan H, İNAN D, UÇAR F, boylubay ö, KOKSOY S, Mutlu E, YUCEL B, Sayın EKİNCİ N (2023). Relationship of HLA-B alleles on susceptibility to and protection from HIV infection in Turkish population. İstanbul Kuzey Klinikleri, 10(1), 67 - 73. 10.14744/nci.2021.00018
Chicago	Darbas Sule,KILINÇ YAHYA,Arslan Habibe Sema,İNAN DİLARA,UÇAR Fahri,boylubay özaydın,KOKSOY SADI,Mutlu Esvet,YUCEL Burcu,Sayın EKİNCİ Nurten Relationship of HLA-B alleles on susceptibility to and protection from HIV infection in Turkish population. İstanbul Kuzey Klinikleri 10, no.1 (2023): 67 - 73. 10.14744/nci.2021.00018
MLA	Darbas Sule,KILINÇ YAHYA,Arslan Habibe Sema,İNAN DİLARA,UÇAR Fahri,boylubay özaydın,KOKSOY SADI,Mutlu Esvet,YUCEL Burcu,Sayın EKİNCİ Nurten Relationship of HLA-B alleles on susceptibility to and protection from HIV infection in Turkish population. İstanbul Kuzey Klinikleri, vol.10, no.1, 2023, ss.67 - 73. 10.14744/nci.2021.00018
AMA	Darbas S,KILINÇ Y,Arslan H,İNAN D,UÇAR F,boylubay ö,KOKSOY S,Mutlu E,YUCEL B,Sayın EKİNCİ N Relationship of HLA-B alleles on susceptibility to and protection from HIV infection in Turkish population. İstanbul Kuzey Klinikleri. 2023; 10(1): 67 - 73. 10.14744/nci.2021.00018
Vancouver	Darbas S,KILINÇ Y,Arslan H,İNAN D,UÇAR F,boylubay ö,KOKSOY S,Mutlu E,YUCEL B,Sayın EKİNCİ N Relationship of HLA-B alleles on susceptibility to and protection from HIV infection in Turkish population. İstanbul Kuzey Klinikleri. 2023; 10(1): 67 - 73. 10.14744/nci.2021.00018
IEEE	Darbas S,KILINÇ Y,Arslan H,İNAN D,UÇAR F,boylubay ö,KOKSOY S,Mutlu E,YUCEL B,Sayın EKİNCİ N "Relationship of HLA-B alleles on susceptibility to and protection from HIV infection in Turkish population." İstanbul Kuzey Klinikleri, 10, ss.67 - 73, 2023. 10.14744/nci.2021.00018
ISNAD	Darbas, Sule vd. "Relationship of HLA-B alleles on susceptibility to and protection from HIV infection in Turkish population". İstanbul Kuzey Klinikleri 10/1 (2023), 67-73. https://doi.org/10.14744/nci.2021.00018