Chard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats
Yıl: 2023 Cilt: 9 Sayı: 2 Sayfa Aralığı: 139 - 147 Metin Dili: İngilizce DOI: 10.3153/FH23013 İndeks Tarihi: 03-05-2023
Chard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats
Öz: Valproic acid, one of the most used drugs for epilepsy patients, has some known side effects. Chard extract has many pharmacological activities. The study aims to evaluate whether valproic acid might interfere with oxidative metabolism in gastric tissue and whether chard ameliorates these effects. The Sprague Dawley rats were divided into four groups (n=8); control, chard-given control, valproic acid, and chard-given valproic acid. The aqueous extracts of chard leaves were given 1 h before the administration of valproic acid for 7 days. On the 8th day, the animals were sacrificed under anesthesia and gastric tissues were homogenized. When compared to the control group, valproic acid significantly increased malondialdehyde and catalase activity, while superoxide dis- mutase activity decreased. Chard administration increased glutathione and, sialic acid levels and decreased malondialdehyde levels and superoxide dismutase activity in the valproic acid group. Based on these findings, since chard increased gastric sialic acid levels, we may suggest that chard may protect gastric mucosa may be through its antioxidant effects.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- Aebi, H. (1984). Catalase in vitro. Methods Enzymology 105, 121-126. https://doi.org/10.1016/s0076-6879(84)05016-3
- Al-Gabri, N., Elnagar, G.M., Saghir, S.A.M., El-Shai- bany, A., Alnomasy, S.F., Althafar, Z.M., Elkomy, N.M.I.M., Elaasser, M.M., Abdoh, M.S., Yosri, M. (2022). Preliminary study of the gastroprotective effect of Aloe perryi and date palm extracts on pyloric ligation-induced gastric ul- cer in experimental rats. BioMed Research International, 9246785. https://doi.org/10.1155/2022/9246785
- Beutler, E. (1975). Glutathione: Red cell metabolism. In: Beutler E, editor. A Manual of Biochemical Methods. New York: Grune and Stratton Inc. 112-114.
- Bhide GP, Colley KJ. (2017). Sialylation of N-glycans: Mechanism, cellular compartmentalization and function. His- tochemistry and Cell Biology 147(2), 149-174. https://doi.org/10.1007/s00418-016-1520-x
- Brown, K., Molcan, E., Rajendiran, E., Nusrat, A., Baker, J., Ruscheinsky, S., Gibson, D. (2014). Free radicals in gas- trointestinal disorders. In: Laher I, editor. Systems biology of free radicals and antioxidants. Berlin: Springer-Verlag. 1691-727.
- Cárdenas-Rodríguez, N., Coballase-Urrutia, E., Rivera- Espinosa, L., Romero-Toledo, A., Sampieri III, A., Or- tega-Cuellar, D., Montesinos-Correa, H., Floriano- Sanchez, E., Carmona-Aparicio, L. (2013). Modulation of antioxidant enzymatic activities by certain antiepileptic drugs (valproic acid, oxcarbazepine, and topiramate): Evidence in humans and experimental models. Oxidative Medicine and Cellular Longevity, 598493. https://doi.org/10.1155/2013/598493
- Chang, T.K., Abbott, F.S. (2006). Oxidative stress as a mechanism of valproic acid-associated hepatotoxicity. Drug Metabolism Reviews, 38(4), 627-639. https://doi.org/10.1080/03602530600959433
- Chateauvieux, S., Morceau, F., Dicato, M., Diederich, M. (2010). Molecular and therapeutic potential and toxicity of valproic acid. Journal of Biomedicine and Biotechnology, 479364. https://doi.org/10.1155/2010/479364
- Dawud, F.A., Mabrouk, M.A., Mohammed, A., Umar, I.A. (2014). Effect of vitamins C & E on aspirin induced gas- tric mucosal damage and oxidative stress. Current Research Journal of Biological Sciences, 6, 36-41. https://doi.org/10.19026/CRJBS.6.5495
- Dean, J.C., Penry, J.K. (1992). Valproate. In: Resor SR, Kutt Jr H, editor. The medical treatment of epilepsy. Florida: CRC Press, Taylor&Francis Group. 265-279. https://doi.org/10.1201/9781003066736
- Đikić, D., Jutrić, D., Dominko, K. (2017). The dual nature of the antiepileptic drug valproic acid, with possible benefi- cial effects in Alzheimer’s disease. Southeastern European Medical Journal, 1(1), 74-89.
- Ertik, O., Sacan, O., Kabasakal, L., Şener, G., Yanardag, R. (2021). Protective effect of chard extract on glycoprotein compounds and advanced oxidation protein product levels in diabetic rat livers. Experimed, 11(1), 27-32. https://doi.org/10.26650/experimed.2021.879204
- Fujii, T., Watanabe, M., Shimizu, T., Takeshima, H., Ku- shiro, K., Takai, M., Sakai, H. (2016). Positive regulation of the enzymatic activity of gastric H+, K+-ATPase by si- alylation of its β-subunit. Biochimica et Biophysica Acta (BBA)-Biomembranes, 1858(6), 1228-1235. https://doi.org/10.1016/j.bbamem.2016.02.029
- Gamba, M., Raguindin, P.F., Asllanaj, E., Merlo, F., Glisic, M., Minder, B., Bussler, W., Metzger, B., Kern, H., Muka, T. (2021). Bioactive compounds and nutritional com- position of swiss chard (Beta vulgaris L. var. cicla and Fla- vescens): A systematic review. Critical Reviews in Food Sci- ence and Nutrition, 61(20), 3465-3480. https://doi.org/10.1080/10408398.2020.1799326
- Gezginci-Oktayoglu, S., Turkyilmaz, I.B., Ercin, M., Yanardag, R., Bolkent, S. (2016). Vitamin U has a protec- tive effect on valproic acid-induced renal damage due to its anti-oxidant, anti-inflammatory, and anti-fibrotic properties. Protoplasma, 253(1), 127-135. https://doi.org/10.1007/s00709-015-0796-3
- Hussein, S.A., Karousa, M.M., Amin, A., Awadalla, M.A. (2016). Evaluation of gastroprotective effect and anti-inflam- matory role of resveratrol against gastric mucosal alterations in experimental model of gastritis in rats. . International Journal of Pharma Sciences, 6(3),1559-1570.
- Jahromi, S.R., Togha, M., Fesharaki, S.H., Najafi, M., Moghadam, N.B., Kheradmand, J.A., Kazemi, H., Gorji, A. (2011). Gastrointestinal adverse effects of antiepileptic drugs in intractable epileptic patients. Seizure, 20(4), 343- 346. https://doi.org/10.1016/j.seizure.2010.12.011
- Johansson, M.E., Sjövall, H., Hansson, G.C. (2013). The gastrointestinal mucus system in health and disease. Nature Reviews Gastroenterology & Hepatology, 10(6), 352-361. https://doi.org/10.1038/nrgastro.2013.35
- Kaplan, K.A., Odabasoglu, F., Halici, Z., Halici, M., Ca- dirci, E., Atalay, F., Aydin, O., Cakir, A. (2012). Alpha- lipoic acid protects against indomethacin-induced gastric ox- idative toxicity by modulating antioxidant system. Journal of Food Science, 77(11), H224-H230. https://doi.org/10.1111/j.1750-3841.2012.02920.x
- Kim, I., Chin, Y.W., Lim, S.W., Kim, Y.C., Kim, J. (2004). Norisoprenoids and hepatoprotective flavone glycosides from the aerial parts of Beta vulgaris var. cicla. Archives of Pharmacal Research, 27(6), 600-603. https://doi.org/10.1007/BF02980156
- Kim, J.W., Choi, C.S., Kim, K.C., Park, J.H., Seung, H., Joo, S.H., Yang, S.M., Shin, C.Y., Park, S.H. (2013). Gas- trointestinal tract abnormalities induced by prenatal valproic acid exposure in rat offspring. Toxicological Research 29(3), 173-179. https://doi.org/10.5487/TR.2013.29.3.173
- Kwiecien, S., Jasnos, K., Magierowski, M., Sliwowski, Z., Pajdo, R., Brzozowski, B., Mach, T., Wojcik, D., Brzozowski, T. (2014). Lipid peroxidation, reactive oxygen species and antioxidative factors in the pathogenesis of gas- tric mucosal lesions and mechanism of protection against ox- idative stress-induced gastric injury. Journal of Physiology and Pharmacology, 65(5), 613-622.
- Laloo D, Prasad SK, Sairam K, Hemalatha S. (2014). Gas- troprotective activity of polyphenolic-rich extract of poten- tilla mooniana. Pharmaceutical Biology, 52(12),1532-42. https://doi.org/10.3109/13880209.2014.905794
- Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R. (1951). Protein Measurement with the Folin Phenol Reagent. The Journal of Biological Chemistry, 193(1), 265-275.
- Myhrstad, M.C., Carlsen, H., Nordström, O., Blomhoff, R., Moskaug, J.Ø. (2002). Flavonoids increase the intracel- lular glutathione level by transactivation of the γ-glutamyl- cysteine synthetase catalytical subunit promoter. Free Radi- cal Biology and Medicine, 32(5), 386-393. https://doi.org/10.1016/s0891-5849(01)00812-7
- Mylorie, A.A., Collins, H., Umbles, C., Kyle, J. (1986). Erythrocyte SOD activity and other parameters of copper sta- tus in rats ingesting lead acetate. Toxicology and Applied Pharmacology, 82(3), 512-520. https://doi.org/10.1016/0041-008x(86)90286-3
- Ogasawara, Y., Namai, T., Yoshino, F., Ishii, K. (2007). Sialic acid is an essential moiety of mucin as a hydroxyl rad- ical scavenger. FEBS letters, 581(13), 2473-2477. https://doi.org/10.1016/j.febslet.2007.04.062
- Ozsoy-Sacan, O., Karabulut-Bulan, O., Bolkent, S., Yanardag, R., Ozgey, Y. (2004). Effects of chard (Beta vul- garis L. var cicla) on the liver of the diabetic rats: A morpho- logical and biochemical study. Bioscience, Biotechnology, and Biochemistry, 68(8), 1640-1648. https://doi.org/10.1271/bbb.68.1640
- Oztopuz, O., Turkon, H., Buyuk, B., Coskun, O., Sehito- glu, M.H., Ovali, M.A., Uzun, M. (2020). Melatonin ame- liorates sodium valproate-induced hepatotoxicity in rats. Mo- lecular Biology Reports, 47(1), 317-325. https://doi.org/10.1007/s11033-019-05134-6
- Ozturk, O., Koklu, S., Koklu, H. (2017). Recurrent gastric polyposis in a patient using antiepileptic drugs for a long time. Gastroenterology Nursing, 40(2), 152-153. https://doi.org/10.1097/SGA.0000000000000281
- Serafim, C., Araruna, M.E., Júnior, E.A., Diniz, M., Hiruma-Lima, C., Batista, L. (2020). A review of the role of flavonoids in peptic ulcer (2010–2020). Molecules, 25(22), 5431. https://doi.org/10.3390/molecules25225431
- Trifunovic, S., Topalovic, A., Knezevic, M., Vajs, V. (2015). Free radicals and antioxidants: Antioxidative and other properties of swiss chard (Beta vulgaris L. subsp. cicla). Agriculture & Forestry, 61(2), 73-92. https://doi.org/10.17707/AgricultForest.61.2.06
- Tunali, S., Cimen, E.S., Yanardag, R. (2020). The effects of chard on brain damage in valproic acid-induced tox- icity. Journal of Food Biochemistry, 44(10), e13382. https://doi.org/10.1111/jfbc.13382
- Ustundag, U.V., Tunali, S., Alev, B., Ipekci, H., Emekli Alturfan, E., Akbay, T.T., Yanardag, R., Yarat, A.. (2015). Effects of chard (Beta vulgaris L. var cicla) on car- diac damage in valproic acid–induced toxicity. Journal of Food Biochemistry 40(2016), 132-139. https://doi.org/10.1111/jfbc.12202
- Vona, R., Pallotta, L., Cappelletti, M., Severi, C., Matarrese, P. (2021). The impact of oxidative stress in hu- man pathology: Focus on gastrointestinal disorders. Antioxi- dants, 10(2), 201. https://doi.org/10.3390/antiox10020201
- Wagner, C.E., Wheeler, K.M., Ribbeck, K. (2018). Mucins and their role in shaping the functions of mucus barriers. An- nual Review of Cell and Developmental Biology, 34,189–215. https://doi.org/10.1146/annurev-cellbio-100617-062818
- Wang, S.H., Wang, Y.Z., Zhang, K.Y., Shen, J.H., Zhou, H.Q., Qiu, X.Y. (2005). Effect of superoxide dismutase and malondialdehyde metabolic changes on carcinogenesis of gastric carcinoma. World Journal of Gastroenterology, 11(28), 4305. https://doi.org/10.3748/wjg.v11.i28.4305
- Warren, L. (1959). The thiobarbituric acid assay of sialic ac- ids. The Journal of Biological Chemistry, 234, 1971-1975. https://doi.org/10.1016/S0021-9258(18)69851-5
- Yagi, K. (1984). Assay for blood plasma or serum. Methods in Enzymology, 105, 328-331. https://doi.org/10.1016/S0076-6879(84)05042-4
- Yang, J.C., Yang, H.C., Shun, C.T., Wang, T.H., Chien, C.T., Kao, J.Y. (2013). Catechins and sialic scid attenuate Helicobacter pylori-triggered epithelial Caspase-1 activity and eradicate Helicobacter pylori infection. Evidence-Based Complementary and Alternative Medicine, 2013, 248585. https://doi.org/10.1155/2013/248585
| APA | Alev-Tuzuner B, TUNALI S, Ustundag U, İpekçi H, Emekli-Alturfan E, Tunali-Akbay T, YANARDAG R, Yarat A (2023). Chard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats. , 139 - 147. 10.3153/FH23013 |
| Chicago | Alev-Tuzuner Burcin,TUNALI SEVIM,Ustundag Unsal Veli,İpekçi Hazal,Emekli-Alturfan Ebru,Tunali-Akbay Tugba,YANARDAG REFIYE,Yarat Aysen Chard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats. (2023): 139 - 147. 10.3153/FH23013 |
| MLA | Alev-Tuzuner Burcin,TUNALI SEVIM,Ustundag Unsal Veli,İpekçi Hazal,Emekli-Alturfan Ebru,Tunali-Akbay Tugba,YANARDAG REFIYE,Yarat Aysen Chard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats. , 2023, ss.139 - 147. 10.3153/FH23013 |
| AMA | Alev-Tuzuner B,TUNALI S,Ustundag U,İpekçi H,Emekli-Alturfan E,Tunali-Akbay T,YANARDAG R,Yarat A Chard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats. . 2023; 139 - 147. 10.3153/FH23013 |
| Vancouver | Alev-Tuzuner B,TUNALI S,Ustundag U,İpekçi H,Emekli-Alturfan E,Tunali-Akbay T,YANARDAG R,Yarat A Chard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats. . 2023; 139 - 147. 10.3153/FH23013 |
| IEEE | Alev-Tuzuner B,TUNALI S,Ustundag U,İpekçi H,Emekli-Alturfan E,Tunali-Akbay T,YANARDAG R,Yarat A "Chard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats." , ss.139 - 147, 2023. 10.3153/FH23013 |
| ISNAD | Alev-Tuzuner, Burcin vd. "Chard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats". (2023), 139-147. https://doi.org/10.3153/FH23013 |
| APA | Alev-Tuzuner B, TUNALI S, Ustundag U, İpekçi H, Emekli-Alturfan E, Tunali-Akbay T, YANARDAG R, Yarat A (2023). Chard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats. Food and Health, 9(2), 139 - 147. 10.3153/FH23013 |
| Chicago | Alev-Tuzuner Burcin,TUNALI SEVIM,Ustundag Unsal Veli,İpekçi Hazal,Emekli-Alturfan Ebru,Tunali-Akbay Tugba,YANARDAG REFIYE,Yarat Aysen Chard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats. Food and Health 9, no.2 (2023): 139 - 147. 10.3153/FH23013 |
| MLA | Alev-Tuzuner Burcin,TUNALI SEVIM,Ustundag Unsal Veli,İpekçi Hazal,Emekli-Alturfan Ebru,Tunali-Akbay Tugba,YANARDAG REFIYE,Yarat Aysen Chard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats. Food and Health, vol.9, no.2, 2023, ss.139 - 147. 10.3153/FH23013 |
| AMA | Alev-Tuzuner B,TUNALI S,Ustundag U,İpekçi H,Emekli-Alturfan E,Tunali-Akbay T,YANARDAG R,Yarat A Chard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats. Food and Health. 2023; 9(2): 139 - 147. 10.3153/FH23013 |
| Vancouver | Alev-Tuzuner B,TUNALI S,Ustundag U,İpekçi H,Emekli-Alturfan E,Tunali-Akbay T,YANARDAG R,Yarat A Chard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats. Food and Health. 2023; 9(2): 139 - 147. 10.3153/FH23013 |
| IEEE | Alev-Tuzuner B,TUNALI S,Ustundag U,İpekçi H,Emekli-Alturfan E,Tunali-Akbay T,YANARDAG R,Yarat A "Chard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats." Food and Health, 9, ss.139 - 147, 2023. 10.3153/FH23013 |
| ISNAD | Alev-Tuzuner, Burcin vd. "Chard extract increased gastric sialic acid and ameliorated oxidative stress in valproic acid-administered rats". Food and Health 9/2 (2023), 139-147. https://doi.org/10.3153/FH23013 |
