Diagnostic Value of Serum H-FABP and NT-proBNP Levels in Determining Cardiac Damage in Cattle with Bovine Respiratory Disease Complex
Yıl: 2023 Cilt: 29 Sayı: 1 Sayfa Aralığı: 71 - 77 Metin Dili: İngilizce DOI: 10.9775/kvfd.2022.28624 İndeks Tarihi: 03-05-2023
Diagnostic Value of Serum H-FABP and NT-proBNP Levels in Determining Cardiac Damage in Cattle with Bovine Respiratory Disease Complex
Öz: Abstract: Cardiac complications associated with respiratory diseases are well-documented in humans, but there are not many studies with cattle. Therefore, this study aimed to investigate cardiac damage in cattle with bovine respiratory disease complex (BRDC) with serum heart-type fatty acid-binding protein (H-FABP), N-terminal pro-peptide natriuretic type B (NT-proBNP) and other known cardiac damage biomarkers [cardiac troponin I (cTnI), creatine kinase-myocardial band (CK-MB), creatine kinase (CK), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH)]. The material of this study consisted of 20 cattle, aged 4-6 months with BRDC (infected group) and 10 healthy cattle aged 4-6 months (control group). The study findings revealed that leukocyte parameters and serum H-FABP, NT-proBNP, cTnI, CK-MB, CK, LDH, and AST levels were higher in cattle with BRDC (P=0.000). Heart rate and respiratory rate showed a strong positive correlation with cardiac damage markers. ROC analysis revealed that serum H-FABP levels with a cut-off value of 0.45 ng/ml were more sensitive (100%) and specific (100%) than the rest in determining cardiac damage. It was concluded that cardiac damage occurred in cattle with BRDC, and H-FABP was more sensitive and specific in detecting cardiac damage. It is anticipated that the use of biomarkers to detect cardiac injury in BRDC will be important for determining prognosis and guiding treatment.
Anahtar Kelime: Sığırların Solunum Sistemi Hastalığı Kompleksinde Kardiyak Hasarın Belirlenmesinde Serum H-FABP ve NT-proBNP Düzeylerinin Tanısal Değeri
Öz: Öz: Solunum yolu hastalıkları ile ilişkili kardiyak komplikasyonlar insanlarda iyi tanımlanmasına rağmen sığırlarda bu alanda çok az çalışma yapılmıştır. Bu nedenle, bu çalışmada sığır solunum hastalığı kompleksi (BRDC) olan sığırlarda serum kalp tipi yağ asidi bağlayıcı protein (H-FABP), N-terminal pro-peptid natriüretik tip B (NT-proBNP) ve bilinen diğer kardiyak hasar biyobelirteçleri [kardiyak troponin I (cTnI), kreatin kinaz-miyokardiyal band (CK-MB), kreatin kinaz (CK), aspartat aminotransferaz (AST) ve laktat dehidrogenaz (LDH)] ile kardiyak hasarın araştırılması amaçlandı. Çalışmanın materyalini BRDC’li (enfekte grup) 4-6 aylık 20 sığır ve 4-6 aylık 10 sağlıklı sığır (kontrol grubu) oluşturdu. Verilerimiz, BRDC’li sığırlarda lökosit parametreleri ve serum H-FABP, NTproBNP, cTnI, CK-MB, CK, LDH ve AST düzeylerinin daha yüksek olduğunu ortaya koydu (P=0.000). Kalp ve solunum hızı, kardiyak hasar belirteçleri ile güçlü pozitif korelasyon gösterdi. ROC analizi, 0,45 ng/ml eşik değerine sahip serum H-FABP düzeylerinin kardiyak hasarı belirlemede diğer tanısal belirteçlere göre daha duyarlı (%100) ve özgül (%100) olduğunu ortaya çıkardı. Sonuç olarak, BRDC’li sığırlarda kardiyak hasarın meydana geldiği ve H-FABP’nin kardiyak hasarı tespit etmede daha duyarlı ve özgül olduğu sonucuna varıldı. BRDC’de kardiyak hasarı saptamak için biyobelirteçlerin kullanılmasının, prognozu belirlemek ve tedaviyi yönlendirmek için önemli olacağı tahmin edilmektedir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Değirmençay Ş (2023). Diagnostic Value of Serum H-FABP and NT-proBNP Levels in Determining Cardiac Damage in Cattle with Bovine Respiratory Disease Complex. , 71 - 77. 10.9775/kvfd.2022.28624 |
| Chicago | Değirmençay Şükrü Diagnostic Value of Serum H-FABP and NT-proBNP Levels in Determining Cardiac Damage in Cattle with Bovine Respiratory Disease Complex. (2023): 71 - 77. 10.9775/kvfd.2022.28624 |
| MLA | Değirmençay Şükrü Diagnostic Value of Serum H-FABP and NT-proBNP Levels in Determining Cardiac Damage in Cattle with Bovine Respiratory Disease Complex. , 2023, ss.71 - 77. 10.9775/kvfd.2022.28624 |
| AMA | Değirmençay Ş Diagnostic Value of Serum H-FABP and NT-proBNP Levels in Determining Cardiac Damage in Cattle with Bovine Respiratory Disease Complex. . 2023; 71 - 77. 10.9775/kvfd.2022.28624 |
| Vancouver | Değirmençay Ş Diagnostic Value of Serum H-FABP and NT-proBNP Levels in Determining Cardiac Damage in Cattle with Bovine Respiratory Disease Complex. . 2023; 71 - 77. 10.9775/kvfd.2022.28624 |
| IEEE | Değirmençay Ş "Diagnostic Value of Serum H-FABP and NT-proBNP Levels in Determining Cardiac Damage in Cattle with Bovine Respiratory Disease Complex." , ss.71 - 77, 2023. 10.9775/kvfd.2022.28624 |
| ISNAD | Değirmençay, Şükrü. "Diagnostic Value of Serum H-FABP and NT-proBNP Levels in Determining Cardiac Damage in Cattle with Bovine Respiratory Disease Complex". (2023), 71-77. https://doi.org/10.9775/kvfd.2022.28624 |
| APA | Değirmençay Ş (2023). Diagnostic Value of Serum H-FABP and NT-proBNP Levels in Determining Cardiac Damage in Cattle with Bovine Respiratory Disease Complex. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 29(1), 71 - 77. 10.9775/kvfd.2022.28624 |
| Chicago | Değirmençay Şükrü Diagnostic Value of Serum H-FABP and NT-proBNP Levels in Determining Cardiac Damage in Cattle with Bovine Respiratory Disease Complex. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 29, no.1 (2023): 71 - 77. 10.9775/kvfd.2022.28624 |
| MLA | Değirmençay Şükrü Diagnostic Value of Serum H-FABP and NT-proBNP Levels in Determining Cardiac Damage in Cattle with Bovine Respiratory Disease Complex. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, vol.29, no.1, 2023, ss.71 - 77. 10.9775/kvfd.2022.28624 |
| AMA | Değirmençay Ş Diagnostic Value of Serum H-FABP and NT-proBNP Levels in Determining Cardiac Damage in Cattle with Bovine Respiratory Disease Complex. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2023; 29(1): 71 - 77. 10.9775/kvfd.2022.28624 |
| Vancouver | Değirmençay Ş Diagnostic Value of Serum H-FABP and NT-proBNP Levels in Determining Cardiac Damage in Cattle with Bovine Respiratory Disease Complex. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2023; 29(1): 71 - 77. 10.9775/kvfd.2022.28624 |
| IEEE | Değirmençay Ş "Diagnostic Value of Serum H-FABP and NT-proBNP Levels in Determining Cardiac Damage in Cattle with Bovine Respiratory Disease Complex." Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 29, ss.71 - 77, 2023. 10.9775/kvfd.2022.28624 |
| ISNAD | Değirmençay, Şükrü. "Diagnostic Value of Serum H-FABP and NT-proBNP Levels in Determining Cardiac Damage in Cattle with Bovine Respiratory Disease Complex". Kafkas Üniversitesi Veteriner Fakültesi Dergisi 29/1 (2023), 71-77. https://doi.org/10.9775/kvfd.2022.28624 |
