Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion

Meriç Emre BOSTANCI, (Cerrahi Bölümü Onkoloji, Sivas Numune Hastanesi, Sivas, Türkiye)
Ceylan HEPOKUR, (Eczacılık Fakültesi Biyokimya Anabilim Dalı, Sivas Cumhuriyet Üniversitesi, Sivas, Türkiye)
Armağan CANER, (Tıp Fakültesi Biyofizik Anabilim Dalı, Erciyes Üniversitesi, Kayseri, Türkiye; ve Erciyes Üniversitesi, Betül Ziya Eren Kök Hücre ve Genom Merkezi, Kayseri, Türkiye.)
Murat Can MOLLAOĞLU, (Cerrahi Onkoloji Bölümü, Sivas Numune Hastanesi, Sivas, Türkiye)
Kürsat KARADAYI (Tıp Fakültesi Cerrahi Anabilim Dalı Onkoloji, Sivas Cumhuriyet Üniversitesi, Sivas, Türkiye.)
Türk Biyokimya Dergisi
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Yıl: 2022 Cilt: 47 Sayı: 5 Sayfa Aralığı: 633 - 639 Metin Dili: İngilizce DOI: 10.1515/tjb-2021-0244 İndeks Tarihi: 08-05-2023

Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion

Öz:
Objectives: Mesenteric ischemia is a surgical emergency caused by poor blood supply to the intestines. In ischemia, the decrease in blood flow to the tissue causes acidosis and cell death through anaerobic metabolism. Clinoptilolite is one of the most abundant natural zeolites, and it is used for its ion exchange and adsorbent properties. Clinoptilolite has been reported to have an immune-enhancing, anticarcinogenic, and antioxidant effect in-vitro/in-vivo studies. Clinoptilolite’s histological and biochemical effects on ischemic small intestines. Methods: The experimental animals were randomly divided into sham, control, and clinoptilolite treatment group. Clinoptilolite was administered intraperitoneally after ischemia/reperfusion. Cardiac blood was stored for biochemical analysis. Total antioxidant levels and total oxidant levels were analyzed from the sera taken from groups. Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) expressions in blood samples were determined by RT-qPCR. At the end of the reperfusion, terminal ileum tissues were taken for histological tests. Results: The mean TNF-α expression level was 3.89 in the control group and 2.91 in the clinoptilolite treatment group. The mean IL-6 expression levels were 2.32 in the control group and 1.49 in the clinoptilolite treatment group. Conclusions: clinoptilolite administration provided healing in the rat ischemia-reperfusion injury model.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA bostancı m, hepokur c, AKKUS A, Mollaoglu M, Karadayı K (2022). Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion. , 633 - 639. 10.1515/tjb-2021-0244
Chicago bostancı meriç emre,hepokur ceylan,AKKUS Armagan,Mollaoglu Murat Can,Karadayı Kursat Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion. (2022): 633 - 639. 10.1515/tjb-2021-0244
MLA bostancı meriç emre,hepokur ceylan,AKKUS Armagan,Mollaoglu Murat Can,Karadayı Kursat Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion. , 2022, ss.633 - 639. 10.1515/tjb-2021-0244
AMA bostancı m,hepokur c,AKKUS A,Mollaoglu M,Karadayı K Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion. . 2022; 633 - 639. 10.1515/tjb-2021-0244
Vancouver bostancı m,hepokur c,AKKUS A,Mollaoglu M,Karadayı K Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion. . 2022; 633 - 639. 10.1515/tjb-2021-0244
IEEE bostancı m,hepokur c,AKKUS A,Mollaoglu M,Karadayı K "Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion." , ss.633 - 639, 2022. 10.1515/tjb-2021-0244
ISNAD bostancı, meriç emre vd. "Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion". (2022), 633-639. https://doi.org/10.1515/tjb-2021-0244
APA bostancı m, hepokur c, AKKUS A, Mollaoglu M, Karadayı K (2022). Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion. Türk Biyokimya Dergisi, 47(5), 633 - 639. 10.1515/tjb-2021-0244
Chicago bostancı meriç emre,hepokur ceylan,AKKUS Armagan,Mollaoglu Murat Can,Karadayı Kursat Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion. Türk Biyokimya Dergisi 47, no.5 (2022): 633 - 639. 10.1515/tjb-2021-0244
MLA bostancı meriç emre,hepokur ceylan,AKKUS Armagan,Mollaoglu Murat Can,Karadayı Kursat Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion. Türk Biyokimya Dergisi, vol.47, no.5, 2022, ss.633 - 639. 10.1515/tjb-2021-0244
AMA bostancı m,hepokur c,AKKUS A,Mollaoglu M,Karadayı K Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion. Türk Biyokimya Dergisi. 2022; 47(5): 633 - 639. 10.1515/tjb-2021-0244
Vancouver bostancı m,hepokur c,AKKUS A,Mollaoglu M,Karadayı K Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion. Türk Biyokimya Dergisi. 2022; 47(5): 633 - 639. 10.1515/tjb-2021-0244
IEEE bostancı m,hepokur c,AKKUS A,Mollaoglu M,Karadayı K "Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion." Türk Biyokimya Dergisi, 47, ss.633 - 639, 2022. 10.1515/tjb-2021-0244
ISNAD bostancı, meriç emre vd. "Possible effects of clinoptilolite on small intestinal ischemia-reperfusion injury caused by experimental mesenteric artery occlusion". Türk Biyokimya Dergisi 47/5 (2022), 633-639. https://doi.org/10.1515/tjb-2021-0244
Sayfa Oluşturulma Tarihi
24-04-2024 6:50

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