Does dietary intake of acrylamide affect hydroxyproline levels? an animal study

Ağbektaş, Tuğba; kılınç, seyran; TAŞ, Ayca; Silig, Yavuz; PAZARCI, Özhan; Keklikcioğlu Çakmak, Neşe

doi:10.5455/medscience.2022.04.082

Does dietary intake of acrylamide affect hydroxyproline levels? an animal study

Tugba AGBEKTAS, (Sivas Cumhuriyet Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Sivas, Türkiye)

ÖZHAN PAZARCI, (Adana Şehir Eğitim ve Araştırma Hastanesi, Ortopedi ve Travmatoloji Anabilim Dalı, Adana, Türkiye)

AYÇA TAŞ, (Sivas Cumhuriyet Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, Sivas, Türkiye)

Neşe KEKLİKCİOĞLU ÇAKMAK, (Sivas Cumhuriyet Üniversitesi, Mühendislik Fakültesi, Kimya Mühendisliği Bölümü, Sivas, Türkiye)

SEYRAN KILINÇ, (Sivas Cumhuriyet Üniversitesi, Tıp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalı, Sivas, Türkiye)

YAVUZ SİLİĞ (Sivas Cumhuriyet Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Sivas, Türkiye)

Medicine Science

1 0

Yıl: 2022 Cilt: 11 Sayı: 4 Sayfa Aralığı: 1478 - 1481 Metin Dili: İngilizce DOI: 10.5455/medscience.2022.04.082 İndeks Tarihi: 08-05-2023

Does dietary intake of acrylamide affect hydroxyproline levels? an animal study

Öz:

Acrylamide is a chemical that occurs due to high temperatures during cooking. It consists of an amino acid found in foods and sugars. Studies have shown that cancer formation occurs within the scope of oxidant reagents and DNA damage due to exposure to acrylamide. Our study aims to examine the effects of dietary acrylamide intake on plasma hydroxyproline levels in rats. In this study, 4 groups were formed with 8 rats in each group (total number=32). Blood samples were collected on days 14 and 28. Acrylamide solution was applied to each rat in the treatment group by gastric gavage process at 5 mg/kg three times a week. Hydroxyproline levels in rats’ plasma samples were measured. The median (IQR) hydroxyproline levels were 7.40(2.45) μg/L in group 1 (14. days control group) and 7.98(3.34) μg/L in group 2 (14. days acrylamide applied) who received acrylamide. The mean hydroxyproline levels were 7.25(1.96) μg/L in group 3 (28. days control group) and 9.76(2.64) μg/L in group 4 (28. days acryl- amide applied) who received acrylamide. No difference was observed between the groups. Dietary acrylamide intake did not have a significant effect on hydroxyproline levels at the application dose and duration in our study.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Ağbektaş T, PAZARCI Ö, TAŞ A, Keklikcioğlu Çakmak N, kılınç s, Silig Y (2022). Does dietary intake of acrylamide affect hydroxyproline levels? an animal study. , 1478 - 1481. 10.5455/medscience.2022.04.082
Chicago	Ağbektaş Tuğba,PAZARCI Özhan,TAŞ Ayca,Keklikcioğlu Çakmak Neşe,kılınç seyran,Silig Yavuz Does dietary intake of acrylamide affect hydroxyproline levels? an animal study. (2022): 1478 - 1481. 10.5455/medscience.2022.04.082
MLA	Ağbektaş Tuğba,PAZARCI Özhan,TAŞ Ayca,Keklikcioğlu Çakmak Neşe,kılınç seyran,Silig Yavuz Does dietary intake of acrylamide affect hydroxyproline levels? an animal study. , 2022, ss.1478 - 1481. 10.5455/medscience.2022.04.082
AMA	Ağbektaş T,PAZARCI Ö,TAŞ A,Keklikcioğlu Çakmak N,kılınç s,Silig Y Does dietary intake of acrylamide affect hydroxyproline levels? an animal study. . 2022; 1478 - 1481. 10.5455/medscience.2022.04.082
Vancouver	Ağbektaş T,PAZARCI Ö,TAŞ A,Keklikcioğlu Çakmak N,kılınç s,Silig Y Does dietary intake of acrylamide affect hydroxyproline levels? an animal study. . 2022; 1478 - 1481. 10.5455/medscience.2022.04.082
IEEE	Ağbektaş T,PAZARCI Ö,TAŞ A,Keklikcioğlu Çakmak N,kılınç s,Silig Y "Does dietary intake of acrylamide affect hydroxyproline levels? an animal study." , ss.1478 - 1481, 2022. 10.5455/medscience.2022.04.082
ISNAD	Ağbektaş, Tuğba vd. "Does dietary intake of acrylamide affect hydroxyproline levels? an animal study". (2022), 1478-1481. https://doi.org/10.5455/medscience.2022.04.082

APA	Ağbektaş T, PAZARCI Ö, TAŞ A, Keklikcioğlu Çakmak N, kılınç s, Silig Y (2022). Does dietary intake of acrylamide affect hydroxyproline levels? an animal study. Medicine Science, 11(4), 1478 - 1481. 10.5455/medscience.2022.04.082
Chicago	Ağbektaş Tuğba,PAZARCI Özhan,TAŞ Ayca,Keklikcioğlu Çakmak Neşe,kılınç seyran,Silig Yavuz Does dietary intake of acrylamide affect hydroxyproline levels? an animal study. Medicine Science 11, no.4 (2022): 1478 - 1481. 10.5455/medscience.2022.04.082
MLA	Ağbektaş Tuğba,PAZARCI Özhan,TAŞ Ayca,Keklikcioğlu Çakmak Neşe,kılınç seyran,Silig Yavuz Does dietary intake of acrylamide affect hydroxyproline levels? an animal study. Medicine Science, vol.11, no.4, 2022, ss.1478 - 1481. 10.5455/medscience.2022.04.082
AMA	Ağbektaş T,PAZARCI Ö,TAŞ A,Keklikcioğlu Çakmak N,kılınç s,Silig Y Does dietary intake of acrylamide affect hydroxyproline levels? an animal study. Medicine Science. 2022; 11(4): 1478 - 1481. 10.5455/medscience.2022.04.082
Vancouver	Ağbektaş T,PAZARCI Ö,TAŞ A,Keklikcioğlu Çakmak N,kılınç s,Silig Y Does dietary intake of acrylamide affect hydroxyproline levels? an animal study. Medicine Science. 2022; 11(4): 1478 - 1481. 10.5455/medscience.2022.04.082
IEEE	Ağbektaş T,PAZARCI Ö,TAŞ A,Keklikcioğlu Çakmak N,kılınç s,Silig Y "Does dietary intake of acrylamide affect hydroxyproline levels? an animal study." Medicine Science, 11, ss.1478 - 1481, 2022. 10.5455/medscience.2022.04.082
ISNAD	Ağbektaş, Tuğba vd. "Does dietary intake of acrylamide affect hydroxyproline levels? an animal study". Medicine Science 11/4 (2022), 1478-1481. https://doi.org/10.5455/medscience.2022.04.082