Remember Diabetes Mellitus When Assessing Renal Blood Flow in Hypertensive Patients: A Renal Frame Count Study

cerik, idris bugra; DİNDAŞ, FERHAT; YILMAZ, MEHMET BIRHAN

doi:10.5543/tkda.2022.77567

Remember Diabetes Mellitus When Assessing Renal Blood Flow in Hypertensive Patients: A Renal Frame Count Study

İdris Buğra ÇERİK, (Cumhuriyet Üniversitesi, Tıp Fakültesi, Kardiyoloji Bölümü, Sivas, Türkiye)

Ferhat DİNDAŞ, (Uşak Eğitim ve Araştırma Hastanesi, Kardiyoloji Bölümü, Uşak, Türkiye)

Mehmet Birhan YILMAZ (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Kardiyoloji Bölümü, İzmir, Türkiye)

Türk Kardiyoloji Derneği Arşivi

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Yıl: 2023 Cilt: 51 Sayı: 1 Sayfa Aralığı: 32 - 39 Metin Dili: İngilizce DOI: 10.5543/tkda.2022.77567 İndeks Tarihi: 11-05-2023

Remember Diabetes Mellitus When Assessing Renal Blood Flow in Hypertensive Patients: A Renal Frame Count Study

Öz:

Objective: Diabetes mellitus (DM) progresses with dynamic changes in renal blood flow and glomerular filtration. Renal frame count (RFC) is a cineangiographical parameter that is capable of presenting microvascular and macrovascular changes in the renal blood flow. We aimed to show the changes, which may be caused by DM in the perfusion, by using RFC. Methods: A total of 110 hypertensive subjects consisting of 55 DM patients and 55 non-DM patients, as a control group who underwent renal angiography, were retrospectively enrolled in the study. The RFC values of all subjects were calculated and compared to each other. Results: There were no significant differences between the two groups in terms of basal demographic characteristics and antihypertensive medications. The RFC value measured from the left renal artery was significantly lower in the DM group compared to the control group (11.33 ± 2.55, 13.49 ± 3.24, respectively; P <0.001). The RFC value measured in the right renal artery was detected to be significantly lower in the DM group than in the control group (11.07 ± 2.43, 13.33 ± 3.07, respectively; P <0.001). The mean RFC value was also significantly lower in the DM group compared to the control group (11.20 ± 2.18, 13.41 ± 2.84, respectively; P <0.001). In the multivariable linear regression analysis conducted to determine the variables which may affect mean RFC, it was determined that only the HbA1C level had a relation with the mean RFC value. Conclusion: To the best of our knowledge, this is the first study to show the influence of DM on RFC. The RFC seems to decrease in DM subjects.

Anahtar Kelime:

Hipertansif Hastalarda Renal Kan Akışını Değerlendirirken Diabetes Mellitus Unutulmamalıdır: Bir Renal Çerçeve Sayım Çalışması

Öz:

Amaç: Diabetes mellitus (DM), renal kan akışında ve glomerüler filtrasyonda dinamik değişikliklerle ilerler. Renal çerçeve sayısı (RFC), renal kan akışındaki mikrovasküler ve makrovasküler değişiklikleri gösterebilen sineanjiyografik bir parametredir. Bu çalışmada biz DM'nin renal perfüzyonda neden olabileceği değişiklikleri RFC kullanarak göstermeyi amaçladık. Yöntemler: Çalışmaya renal anjiyografi yapılan 55 DM hastası ve 55 DM olmayan hasta olmak üzere toplam 110 hipertansif olgu retrospektif olarak alındı. Tüm deneklerin RFC değerleri hesaplandı ve birbirleriyle karşılaştırıldı. Bulgular: Bazal demografik özellikler ve antihipertansif ilaçlar açısından iki grup arasında anlamlı fark yoktu. Sol renal arterden ölçülen RFC değeri DM grubunda kontrol grubuna göre anlamlı derecede düşüktü. (sırasıyla 11,33 ± 2,55, 13,49 ± 3,24; P <0,001). Sağ renal arterden ölçülen RFC değeri DM grubunda kontrol grubuna göre anlamlı derecede düşük saptandı (sırasıyla 11,07 ± 2,43, 13,33 ± 3,07; P <0,001). Ortalama RFC değeri de DM grubunda kontrol grubuna göre anlamlı olarak daha düşüktü (sırasıyla 11,20 ± 2,18, 13,41 ± 2,84, P <0,001). Ortalama RFC'yi etkileyebilecek değişkenleri belirlemek için yapılan çok değişkenli lineer regres-yon analizinde, ortalama RFC değeri ile sadece HbA1C düzeyinin ilişkisi olduğu belirlendi. Sonuç: Bildiğimiz kadarıyla bu çalışma DM ile RFC arasındaki ilişkiyi araştıran ilk çalışmadır. DM hastalarında renal kan akımındaki artışa paralel olarak RFC azalmaktadır. RFC'nin klinik kullanımında bu ilişki dikkate alınmalıdır.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	cerik i, DİNDAŞ F, YILMAZ M (2023). Remember Diabetes Mellitus When Assessing Renal Blood Flow in Hypertensive Patients: A Renal Frame Count Study. , 32 - 39. 10.5543/tkda.2022.77567
Chicago	cerik idris bugra,DİNDAŞ FERHAT,YILMAZ MEHMET BIRHAN Remember Diabetes Mellitus When Assessing Renal Blood Flow in Hypertensive Patients: A Renal Frame Count Study. (2023): 32 - 39. 10.5543/tkda.2022.77567
MLA	cerik idris bugra,DİNDAŞ FERHAT,YILMAZ MEHMET BIRHAN Remember Diabetes Mellitus When Assessing Renal Blood Flow in Hypertensive Patients: A Renal Frame Count Study. , 2023, ss.32 - 39. 10.5543/tkda.2022.77567
AMA	cerik i,DİNDAŞ F,YILMAZ M Remember Diabetes Mellitus When Assessing Renal Blood Flow in Hypertensive Patients: A Renal Frame Count Study. . 2023; 32 - 39. 10.5543/tkda.2022.77567
Vancouver	cerik i,DİNDAŞ F,YILMAZ M Remember Diabetes Mellitus When Assessing Renal Blood Flow in Hypertensive Patients: A Renal Frame Count Study. . 2023; 32 - 39. 10.5543/tkda.2022.77567
IEEE	cerik i,DİNDAŞ F,YILMAZ M "Remember Diabetes Mellitus When Assessing Renal Blood Flow in Hypertensive Patients: A Renal Frame Count Study." , ss.32 - 39, 2023. 10.5543/tkda.2022.77567
ISNAD	cerik, idris bugra vd. "Remember Diabetes Mellitus When Assessing Renal Blood Flow in Hypertensive Patients: A Renal Frame Count Study". (2023), 32-39. https://doi.org/10.5543/tkda.2022.77567

APA	cerik i, DİNDAŞ F, YILMAZ M (2023). Remember Diabetes Mellitus When Assessing Renal Blood Flow in Hypertensive Patients: A Renal Frame Count Study. Türk Kardiyoloji Derneği Arşivi, 51(1), 32 - 39. 10.5543/tkda.2022.77567
Chicago	cerik idris bugra,DİNDAŞ FERHAT,YILMAZ MEHMET BIRHAN Remember Diabetes Mellitus When Assessing Renal Blood Flow in Hypertensive Patients: A Renal Frame Count Study. Türk Kardiyoloji Derneği Arşivi 51, no.1 (2023): 32 - 39. 10.5543/tkda.2022.77567
MLA	cerik idris bugra,DİNDAŞ FERHAT,YILMAZ MEHMET BIRHAN Remember Diabetes Mellitus When Assessing Renal Blood Flow in Hypertensive Patients: A Renal Frame Count Study. Türk Kardiyoloji Derneği Arşivi, vol.51, no.1, 2023, ss.32 - 39. 10.5543/tkda.2022.77567
AMA	cerik i,DİNDAŞ F,YILMAZ M Remember Diabetes Mellitus When Assessing Renal Blood Flow in Hypertensive Patients: A Renal Frame Count Study. Türk Kardiyoloji Derneği Arşivi. 2023; 51(1): 32 - 39. 10.5543/tkda.2022.77567
Vancouver	cerik i,DİNDAŞ F,YILMAZ M Remember Diabetes Mellitus When Assessing Renal Blood Flow in Hypertensive Patients: A Renal Frame Count Study. Türk Kardiyoloji Derneği Arşivi. 2023; 51(1): 32 - 39. 10.5543/tkda.2022.77567
IEEE	cerik i,DİNDAŞ F,YILMAZ M "Remember Diabetes Mellitus When Assessing Renal Blood Flow in Hypertensive Patients: A Renal Frame Count Study." Türk Kardiyoloji Derneği Arşivi, 51, ss.32 - 39, 2023. 10.5543/tkda.2022.77567
ISNAD	cerik, idris bugra vd. "Remember Diabetes Mellitus When Assessing Renal Blood Flow in Hypertensive Patients: A Renal Frame Count Study". Türk Kardiyoloji Derneği Arşivi 51/1 (2023), 32-39. https://doi.org/10.5543/tkda.2022.77567