Vitamin D in Behcet’s Disease, a Brief Review of the Literature
Yıl: 2022 Cilt: 54 Sayı: 1 Sayfa Aralığı: 29 - 33 Metin Dili: İngilizce DOI: 10.5152/eurasianjmed.2022.22300 İndeks Tarihi: 24-05-2023
Vitamin D in Behcet’s Disease, a Brief Review of the Literature
Öz: Behcet’s disease is a chronic vasculitis of unknown etiopathogenesis. Serum vitamin D levels have been reported to be associated with a variety of inflammatory and autoimmune diseases one of which is Behcet’s disease. The previous studies about vitamin D in Behcet’s disease seem to be focused on 4 main categories; the studies evaluating serum vitamin D levels between patients with Behcet’s disease and controls, the studies evaluating serum vitamin D in the susceptibility and pathogenesis of Behcet’s disease, the studies evaluating serum vitamin D in clinical involvements and activity of Behcet’s disease, and the studies evaluating the effect of serum vitamin D replacement in Behcet’s disease. The aim of this manuscript was to evaluate the results of the studies on serum vitamin D in Behcet’s disease and review the literature.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
- 1. van der Houwen TB, van Hagen PM, van Laar JAM. Immunopathogenesis of Behçet’s disease and treatment modalities. Semin Arthritis Rheum. 2022;52:151956. [CrossRef]
- 2. Melikoğlu MA, Melikoğlu M. The influence of age on Behcet’s disease activity. Eurasian J Med. 2008;40(2):68-71.
- 3. Greco A, De Virgilio A, Ralli M, et al. Behçet’s disease: new insights into pathophysiology, clinical features and treatment options. Autoimmun Rev. 2018;17(6):567-575. [CrossRef]
- 4. Kul A, Ateş O, Alkan Melikoğlu M, et al. Endocan measurement for active Behcet disease. Arch Rheumatol. 2017;32(3):197-202. [CrossRef]
- 5. Khairallah M, Accorinti M, Muccioli C, Kahloun R, Kempen JH. Epidemiology of Behçet disease. Ocul Immunol Inflammm. 2012;20(5):324-335. [CrossRef]
- 6. Akkoç N. Update on the epidemiology, risk factors and disease outcomes of Behçet’s disease. Best Pract Res Clin Rheumatol. 2018;32(2):261- 270. [CrossRef]
- 7. Balkan E, Dogan H, Bilen H, et al. The determination of immunoregulator gene expression levels in Behcet’s patients. Comptes Rendus de l Academie Bulgare des Sciences. 2019;72:1269-1275.
- 8. Ortiz-Fernández L, Sawalha AH. Genetics of Behçet’s disease: functional genetic analysis and estimating disease heritability. Front Med (Lausanne). 2021;8:625710. [CrossRef]
- 9. Uzkeser H, Haliloglu S, Cayir Y, et al. Is mean platelet volume a new activity criteria in Behçet’s disease? Blood Coagul Fibrinolysis. 2015;26(7):836- 839. [CrossRef]
- 10. Rodríguez-Carrio J, Nucera V, Masala IF, Atzeni F. Behçet disease: from pathogenesis to novel therapeutic options. Pharmacol Res. 2021;167:105593. [CrossRef]
- 11. Mehmood N, Low L, Wallace GR. Behçet’s disease - do microbiomes and genetics collaborate in pathogenesis? Front Immunol. 2021;12:648341. [CrossRef]
- 12. Kul A, Öztürk N, Arslan Y, Baygutalp F. Serum melatonin levels in patients with Behcet’s disease. Turk J Osteoporos. 2020;26 (2):104-109. [CrossRef]
- 13. Nieto IG, Alabau JLC. Immunopathogenesis of Behçet disease. Curr Rheumatol Rev. 2020;16(1):12-20. [CrossRef]
- 14. Yılmaz MA, Türsen Ü. The immunogenetics of Behcet’s disease. Adv Exp Med Biol. 2022;1367:335- 347. [CrossRef]
- 15. Messedi M, Guidara W, Grayaa S, et al. Selected plasma oxysterols as a potential multi-marker biosignature panel for Behçet’s disease. J Steroid Biochem Mol Biol. 2022;221:106122. [CrossRef]
- 16. Araz O, Karaman A, Yilmazel Ucar E, Saglam L, Akgun M. Behçet’s disease: different systemic manifestations at different ages. Eurasian J Med. 2020;52(3):304-306. [CrossRef]
- 17. Arica DA, Akşan B, Örem A, Altinkaynak BA, Yayli S, Sönmez M. High levels of endothelial progenitor cells and circulating endothelial cells in patients with Behçet’s disease and their relationship to disease activity. An Bras Dermatol. 2019;94(3):320-326. [CrossRef]
- 18. Bouillet L, Baudet AE, Deroux A, et al. Autoantibodies to vascular endothelial cadherin in humans: association with autoimmune diseases. Lab Invest. 2013;93(11):1194-1202. [CrossRef]
- 19. Lisitsyna T, Alekberova Z, Ovcharov P, Volkov A, Korsakova J, Nasonov E. Left ventricular intracardiac thrombus in a patient with Behçet disease successfully treated with immunosuppressive agents without anticoagulation: a case report and review of the literature. Rheumatol Int. 2015;35(11):1931-1935. [CrossRef]
- 20. Yalçındağ A, Gedik-Oğuz Y, Yalçındağ FN. The relationship between serum levels of angiogenin, bFGF, VEGF, and ocular involvement in patients with Behçet’s disease. Graefes Arch Clin Exp Ophthalmol. 2013;251(7):1807-1812. [CrossRef]
- 21. El Boghdady NA, Shaker OG. Role of serum miR-181b, proinflammatory cytokine, and adhesion molecules in Behçet’s disease. J Interferon Cytokine Res. 2019;39(6):347-354. [CrossRef]
- 22. Akdemir S, Sari RA, Kiziltunc A, Gundogdu M, Kiki I. Thrombophilic factors in Behcet’s disease and association with clinic manifestations. Eurasian J Med. 2006;38:49-56.
- 23. Emmi G, Bettiol A, Silvestri E, et al. Vascular Behçet’s syndrome: an update. Intern Emerg Med. 2019;14(5):645-652. [CrossRef]
- 24. Dzhus MB, Karasevska TA, Tsaralunga VM, Yurchenko AV, Ivashkivsky OI. Behçet’s disease with intestinal involvement: case-based review. Rheumatol Int. 2022;42(9):1653-1660. [CrossRef]
- 25. Ksiaa I, Abroug N, Kechida M, et al. Eye and Behçet’s disease. J Fr Ophtalmol. 2019;42(4):e133-e146. [CrossRef]
- 26. Leccese P, Padula MC, Lascaro N, Padula AA, D’Angelo S. Clinical phenotypes of Behçet’s syndrome in a large cohort of Italian patients: focus on gender differences. Scand J Rheumatol. 2021;50(6):475-478. [CrossRef]
- 27. Demirelli S, Degirmenci H, Bilen H, et al. Left ventricular mechanics in Behcet’s disease: a speckle tracking echocardiographic study. Bosnian J Basic Med Sci. 2014;14(3):160-164. [CrossRef]
- 28. Nguyen A, Upadhyay S, Javaid MA, et al. Behcet’s disease: an in-depth review about pathogenesis, gastrointestinal manifestations, and management. Inflamm Intest Dis. 2021;6(4):175-185. [CrossRef]
- 29. Gheita TA, Fathi HM, Eesa NN, et al. Development of an Arabic version of the Behçet’s disease current activity form. Clin Rheumatol. 2021;40(11):4609-4618. [CrossRef]
- 30. Melikoglu M, Topkarci Z. Is there a relation between clinical disease activity and acute phase response in Behcet’s disease? Int J Dermatol. 2014;53(2):250-254. [CrossRef]
- 31. Floris A, Espinosa G, Serpa Pinto L, et al. BODI Project collaborators. Discordance between patient and physician global assessment of disease activity in Behçet’s syndrome: a multicenter study cohort. Arthritis Res Ther. 2020;22(1):278. [CrossRef]
- 32. Mastrolia MV, Marinello D, Di Cianni F, Talarico R, Simonini G. Assessing quality of life in Behçet’s disease: a systematic review. Clin Exp Rheumatol. 2022;40(8):1560-1566. [CrossRef]
- 33. Melikoğlu M, Melikoglu MA. What affects the quality of life in patients with Behcet’s disease? Acta Reumatol Port. 2014;39(1):46-53.
- 34. Melikoglu MA, Melikoglu M. The relationship between disease activity and depression in patients with Behcet disease and rheumatoid arthritis. Rheumatol Int. 2010;30(7):941-946. [CrossRef]
- 35. Melikoglu M, Melikoglu MA. The prevalence of fibromyalgia in patients with Behçet’s disease and its relation with disease activity. Rheumatol Int. 2013;33(5):1219-1222. [CrossRef]
- 36. Balcancı O, Melikoglu MA. The relationship between hydroxyvitamin D levels and fall risk in young adults. J Bone Miner Metab. 2021;39(6): 1076-1081. [CrossRef]
- 37. Ismailova A, White JH. Vitamin D, infections and immunity. Rev Endocr Metab Disord. 2022;23(2):265-277. [CrossRef]
- 38. Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol. 2014;144(A):138-145. [CrossRef]
- 39. Grant WB, Lahore H, McDonnell SL, et al. Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths. Nutrients. 2020;12(4):988. [CrossRef]
- 40. Siddiqui M, Manansala JS, Abdulrahman HA, et al. Immune modulatory effects of vitamin D on viral infections. Nutrients. 2020;12(9):2879. [CrossRef]
- 41. Mercola J, Grant WB, Wagner CL. Evidence regarding vitamin D and risk of COVID-19 and its severity. Nu
- 42. Bae M, Kim H. Mini-review on the roles of vitamin C, vitamin D, and selenium in the immune system against COVID-19. Molecules. 2020; 25(22):5346. [CrossRef]
- 43. Kumar R, Rathi H, Haq A, Wimalawansa SJ, Sharma A. Putative roles of vitamin D in modulating immune response and immunopathology associated with COVID-19. Virus Res. 2021; 292:198235. [CrossRef]
- 44. Sacerdote A, Dave P, Lokshin V, Bahtiyar G. Type 2 diabetes mellitus, insulin resistance, and vitamin D. Curr Diab Rep. 2019;19(10):101. [CrossRef]
- 45. Maddaloni E, Cavallari I, Napoli N, Conte C. Vitamin D and diabetes mellitus. Front Horm Res. 2018;50:161-176. [CrossRef]
- 46. Zhao R, Zhang W, Ma C, et al. Immunomodulatory function of vitamin D and its role in autoimmune thyroid disease. Front Immunol. 2021;12:574967. [CrossRef]
- 47. Ashok T, Palyam V, Azam AT, et al. Relationship between vitamin D and thyroid: an enigma. Cureus. 2022;14(1):e21069. [CrossRef]
- 48. Hu Z, Zhi X, Li J, et al. Effects of long-term vitamin D supplementation on metabolic profile in middle-aged and elderly patients with type 2 diabetes. J Steroid Biochem Mol Biol. 2023;225:106198. [CrossRef]
- 49. Matías-Guíu J, Oreja-Guevara C, Matias-Guiu JA, Gomez-Pinedo U. Vitamin D and remyelination in multiple sclerosis. Neurol (Engl Ed). 2018;33(3):177-186. [CrossRef]
- 50. Bivona G, Gambino CM, Iacolino G, Ciaccio M. Vitamin D and the nervous system. Neurol Res. 2019;41(9):827-835. [CrossRef]
- 51. Sincan G, Erdem F. The effects of vitamin D level on bone lesions and prognostic factors in multiple myeloma. Meandros Med Dent J. 2021;22 (2):196-202. [CrossRef]
- 52. Jeon SM, Shin EA. Exploring vitamin D metabolism and function in cancer. Exp Mol Med. 2018;50(4):1-14. [CrossRef]
- 53. de La Puente-Yagüe M, Cuadrado-Cenzual MA, Ciudad-Cabañas MJ, Hernández-Cabria M, Collado- Yurrita L. Vitamin D and its role in breast cancer. Kaohsiung J Med Sci. 2018;34(8):423-427. [CrossRef]
- 54. Trump DL, Aragon-Ching JB. Vitamin D in prostate cancer. Asian J Androl. 2018;20(3):244-252. [CrossRef]
- 55. Nica-Badea D, Udristioiu A. The relevance of supplemental vitamin D in malignancies. Anti Cancer Agents Med Chem. 2021;21(15):1942- 1949. [CrossRef]
- 56. Gnagnarella P, Raimondi S, Aristarco V, et al. Vitamin D receptor polymorphisms and cancer. Adv Exp Med Biol. 2020;1268:53-114. [CrossRef]
- 57. Cantorna MT, Zhu Y, Froicu M, Wittke A. Vitamin D status, 1,25- dihyd roxyv itami n D3, and the immune system. Am J Clin Nutr. 2004;80(6):1717S- 1720S. [CrossRef]
- 58. Akbas EM, Gungor A, Ozcicek A, Akbas N, Askin S, Polat M. Vitamin D and inflammation: evaluation with neutr ophil -to-l ympho cyte ratio and plate let-t o-lym phocy te ratio. Arch Med Sci. 2016;12(4):721-727. [CrossRef]
- 59. Baykal T, Senel K, Alp F, Erdal A, Ugur M. Is there an association between serum 25-hydroxyvitamin D concentrations and disease activity in rheumatoid arthritis? Bratisl Lek Listy. 2012;113(10):610-611. [CrossRef]
- 60. Rosen Y, Daich J, Soliman I, Brathwaite E, Shoenfeld Y. Vitamin D and autoimmunity. Scand J Rheumatol. 2016;45(6):439-447. [CrossRef]
- 61. Anapali M, Dagistanli FK, Akdemir AS, et al. Combined resveratrol and vitamin D treatment ameliorate inflammation-related liver fibrosis, ER stress, and apoptosis in a high-fructose diet/ strep tozot ocin- induc ed T2DM model. Histochem Cell Biol. 2022;158(3):279-296.
- 62. Yamamoto EA, Jørgensen TN. Relationships between vitamin D, gut microbiome, and systemic autoimmunity. Front Immunol. 2019;10:3141. [CrossRef]
- 63. Karatay S, Yildirim K, Karakuzu A, et al. Vitamin D status in patients with Behcet’s disease. Clinics (Sao Paulo). 2011;66(5):721-723. [CrossRef]
- 64. Khabbazi A, Rashtchizadeh N, Ghorbanihaghjo A, et al. The status of serum vitamin D in patients with active Behcet’s disease compared with controls. Int J Rheum Dis. 2014;17(4):430- 434. [CrossRef]
- 65. Adeeb F, Khan MU, Li X, Stack AG, Devlin J, Fraser AD. High vitamin D levels may downregulate inflammation in patients with Behçet’s disease. Int J Inflam. 2017;2017:8608716. [CrossRef]
- 66. Faezi ST, Ansari N, Paragomi P, Akhlaghi M, Ghanavat M, Davatchi F. Vitamin D deficiency in patients with Behcet’s disease. J Diabetes Metab Disord. 2014; 13(1):18. [CrossRef]
- 67. Pitukweerakul S, Sinyagovskiy P, Prachuapthunyachart S. The association between vitamin D level and Behcet’s disease: a meta-analysis. Int J Rheum Dis. 2017;20(12):2217-2218. [CrossRef]
- 68. Dal NE, Cerci P, Olmez U, Keskin G. The role of vitamin D receptor gene polymorphisms in the pathogenesis of Behcet’s disease: a case-control study in Turkish population. Ann Hum Genet. 2019;83(3):177-186. [CrossRef]
- 69. Kolahi S, Khabbazi A, Khodadadi H, et al. Vitamin D receptor gene polymorphisms in Iranian Azary patients with Behçet’s disease. Scand J Rheumatol. 2015;44(2):163-167. [CrossRef]
- 70. Shirvani SS, Nouri M, Sakhinia E, et al. The expression and methylation status of vitamin D receptor gene in Behcet’s disease. Immun Inflamm Dis. 2019;7(4):308-317. [CrossRef]
- 71. Erten G, Kalkan M , Gazioğlu SG , et al. Polymorphisms in the vitamin D receptor in Behçet’s disease in Turkish population. Dis Markers. 2016;2016:7475080.
- 72. Karray EF, Ben Dhifallah I, Ben Abdelghani K, et al. Associations of vitamin D receptor gene polymorphisms FokI and BsmI with susceptibility to rheumatoid arthritis and Behçet’s disease in Tunisians. Joint Bone Spine. 2012;79(2):144-148. [CrossRef]
- 73. Fang J, Hou S, Xiang Q, et al. Polymorphisms in genetics of vitamin D metabolism confer susceptibility to ocular Behçet disease in a Chinese Han population. Am J Ophthalmol. 2014;157(2):488- 494.e6. [CrossRef]
- 74. Hamzaoui K, Ben Dhifallah IB, Karray E, Sassi FH, Hamzaoui A. Vitamin D modulates peripheral immunity in patients with Behçet’s disease. Clin Exp Rheumatol. 2010;28(4)(suppl 60):S50-S57.
- 75. Do JE, Kwon SY, Park S, Lee ES. Effects of vitamin D on expression of Toll-like receptors of monocytes from patients with Behcet’s disease. Rheumatol (Oxf Engl). 2008;47(6):840-848. [CrossRef]
- 76. Zhong Z, Su G, Du L, et al. Higher 25-hydroxyvitamin D level is associated with increased risk for Behçet’s disease. Clin Nutr. 2021;40(2):518- 524. [CrossRef]
- 77. Mirfeizi Z, Tabaei S, Ravanshad Y, Hashemzadeh K, Kharazmi E, Mehrad-Majd H. Associations between vitamin D receptor polymorphisms and susceptibility to Behcet’s disease: a meta-analysis. Immunol Investig. 2018;47(4):389-402. [CrossRef]
- 78. Can M, Gunes M, Haliloglu OA, et al. Effect of vitamin D deficiency and replacement on endothelial functions in Behçet’s disease. Clin Exp Rheumatol. 2012;30(3):S57-S61.
- 79. Omar HS, Taha FM, Fouad S, et al. The association between vitamin D levels and oxidative stress markers in Egyptian Behcet’s disease patients. Orphanet J Rare Dis. 2022;17(1):264. [CrossRef]
- 80. Djeraba Z, Benlabidi F, Djaballah-Ider FZ, et al. Vitamin D status in Algerian Behçet’s disease patients: an immunomodulatory effect on NO pathway. Immunopharmacol Immunotoxicol. 2017;39(4):243-250. [CrossRef]
- 81. Ganeb SS, Sabry HH, El-Assal MM, Kamal HM, Fayed AA . Vitamin D levels in patients with Behçet’s disease: significance and impact on disease measures. Egypt Rheumatol. 2013;35(3):151- 157. [CrossRef]
- 82. Kul A, Erdal A. Bone mineral density and vitamin D values in Behcet’s disease. Turk J Osteoporos. 2018;3:78-83.
- 83. Aslan N, Demirci K, Güler T, Dörtbaş F, Kale E. The effect of vitamin D on clinical manifestations and activity of Behcet’s disease. Postepy Dermatol Alergol. 2017;34(1):15-20. [CrossRef]
- 84. Khabbazi A, Ghojazadeh M, Hajebrahimi S, Nikniaz Z. Relationship between vitamin D level and Bechcet’s disease activity: a systematic review and meta-analysis. Int J Vitam Nutr Res. 2020;90(5-6):527-534. [CrossRef]
- 85. Hashemzadeh K, Rezazadeh M, Eftekhari A, Esparham A, Jokar MH, Kheradmand HR. Vitamin D levels in patients with Behcet’s disease: systematic review and meta-analysis. Curr Rheumatol Rev. 2022;18(3):203-211. [CrossRef]
- 86. Güngör Ş, Gökdemir G, Çiçek YG, Topal İO, Canat D. The effect of 25(OH)D on endothelial and immunological markers in Behcet’s disease. J Dermatolog Treat. 2016;27(3):254-259. [CrossRef]
- 87. Choi B, Lee ES, Sohn S. Vitamin D3 ameliorates herpes simplex virus-induced Behçet’s diseaselike inflammation in a mouse model through down-regulation of Toll-like receptors. Clin Exp Rheumatol. 2011;29(4):S13-S19.
| APA | Melikoglu M, ŞAHİN M, Alkan Melikoglu M (2022). Vitamin D in Behcet’s Disease, a Brief Review of the Literature. , 29 - 33. 10.5152/eurasianjmed.2022.22300 |
| Chicago | Melikoglu Mehmet,ŞAHİN Mestan,Alkan Melikoglu Meltem Vitamin D in Behcet’s Disease, a Brief Review of the Literature. (2022): 29 - 33. 10.5152/eurasianjmed.2022.22300 |
| MLA | Melikoglu Mehmet,ŞAHİN Mestan,Alkan Melikoglu Meltem Vitamin D in Behcet’s Disease, a Brief Review of the Literature. , 2022, ss.29 - 33. 10.5152/eurasianjmed.2022.22300 |
| AMA | Melikoglu M,ŞAHİN M,Alkan Melikoglu M Vitamin D in Behcet’s Disease, a Brief Review of the Literature. . 2022; 29 - 33. 10.5152/eurasianjmed.2022.22300 |
| Vancouver | Melikoglu M,ŞAHİN M,Alkan Melikoglu M Vitamin D in Behcet’s Disease, a Brief Review of the Literature. . 2022; 29 - 33. 10.5152/eurasianjmed.2022.22300 |
| IEEE | Melikoglu M,ŞAHİN M,Alkan Melikoglu M "Vitamin D in Behcet’s Disease, a Brief Review of the Literature." , ss.29 - 33, 2022. 10.5152/eurasianjmed.2022.22300 |
| ISNAD | Melikoglu, Mehmet vd. "Vitamin D in Behcet’s Disease, a Brief Review of the Literature". (2022), 29-33. https://doi.org/10.5152/eurasianjmed.2022.22300 |
| APA | Melikoglu M, ŞAHİN M, Alkan Melikoglu M (2022). Vitamin D in Behcet’s Disease, a Brief Review of the Literature. Eurasian Journal of Medicine, 54(1), 29 - 33. 10.5152/eurasianjmed.2022.22300 |
| Chicago | Melikoglu Mehmet,ŞAHİN Mestan,Alkan Melikoglu Meltem Vitamin D in Behcet’s Disease, a Brief Review of the Literature. Eurasian Journal of Medicine 54, no.1 (2022): 29 - 33. 10.5152/eurasianjmed.2022.22300 |
| MLA | Melikoglu Mehmet,ŞAHİN Mestan,Alkan Melikoglu Meltem Vitamin D in Behcet’s Disease, a Brief Review of the Literature. Eurasian Journal of Medicine, vol.54, no.1, 2022, ss.29 - 33. 10.5152/eurasianjmed.2022.22300 |
| AMA | Melikoglu M,ŞAHİN M,Alkan Melikoglu M Vitamin D in Behcet’s Disease, a Brief Review of the Literature. Eurasian Journal of Medicine. 2022; 54(1): 29 - 33. 10.5152/eurasianjmed.2022.22300 |
| Vancouver | Melikoglu M,ŞAHİN M,Alkan Melikoglu M Vitamin D in Behcet’s Disease, a Brief Review of the Literature. Eurasian Journal of Medicine. 2022; 54(1): 29 - 33. 10.5152/eurasianjmed.2022.22300 |
| IEEE | Melikoglu M,ŞAHİN M,Alkan Melikoglu M "Vitamin D in Behcet’s Disease, a Brief Review of the Literature." Eurasian Journal of Medicine, 54, ss.29 - 33, 2022. 10.5152/eurasianjmed.2022.22300 |
| ISNAD | Melikoglu, Mehmet vd. "Vitamin D in Behcet’s Disease, a Brief Review of the Literature". Eurasian Journal of Medicine 54/1 (2022), 29-33. https://doi.org/10.5152/eurasianjmed.2022.22300 |
