LC-MS/MS analysis and biological activities of endemic Achillea sieheana Stapf from Türkiye

Tuğçe DİKPINAR, (Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Marmara Üniversitesi, İstanbul, Türkiye)
Fatih GÖGER, (Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Anadolu Üniversitesi, Eskişehir, Türkiye)
Leyla BİTİŞ (Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Marmara Üniversitesi, İstanbul, Türkiye)
Journal of research in pharmacy (online)
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Yıl: 2022 Cilt: 26 Sayı: 6 Sayfa Aralığı: 1796 - 1804 Metin Dili: İngilizce DOI: 10.29228/jrp.270 İndeks Tarihi: 27-05-2023

LC-MS/MS analysis and biological activities of endemic Achillea sieheana Stapf from Türkiye

Öz:
In this study, in vitro ABTS, DPPH, 5-lipoxygenase, and α-glucosidase inhibitory activities of n-hexane (ASH), dichloromethane (ASD), ethyl acetate (ASE), and methanol (ASM) extracts from the aerial parts of endemic A. sieheana were assayed for the first time. The phytochemical content of ASE, the most active extract, has been first determined by LC-MS/MS. Also, the total amount of phenolic compounds of extracts were calculated. ASE demonstrated significant antioxidant activity with IC50 values of 0.096 and 0.156 mg/mL for ABTS and DPPH, respectively. ASD and ASE with IC50 values of 0.045 and 0.089 mg/mL exhibited significant anti-inflammatory activity. ASE showed moderate α-glucosidase inhibitory activity with an IC50 value of 0.774 mg/mL. Also, the total phenolic content was found to be highest in the ASE. Feruloylquinic acid, luteolin, luteolin glucoside, isorhamnetin, isovitexin, methoxyflavonoid like chrysoeriol and its glycoside derivative in the ASE were detected by LC-MS/MS. The results demonstrated that ASE had significant anti-inflammatory, antioxidant and moderate α-glucosidase inhibitory potential.
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APA DİKPINAR T, Göger F, Bitis L (2022). LC-MS/MS analysis and biological activities of endemic Achillea sieheana Stapf from Türkiye. , 1796 - 1804. 10.29228/jrp.270
Chicago DİKPINAR TUĞÇE,Göger Fatih,Bitis Leyla LC-MS/MS analysis and biological activities of endemic Achillea sieheana Stapf from Türkiye. (2022): 1796 - 1804. 10.29228/jrp.270
MLA DİKPINAR TUĞÇE,Göger Fatih,Bitis Leyla LC-MS/MS analysis and biological activities of endemic Achillea sieheana Stapf from Türkiye. , 2022, ss.1796 - 1804. 10.29228/jrp.270
AMA DİKPINAR T,Göger F,Bitis L LC-MS/MS analysis and biological activities of endemic Achillea sieheana Stapf from Türkiye. . 2022; 1796 - 1804. 10.29228/jrp.270
Vancouver DİKPINAR T,Göger F,Bitis L LC-MS/MS analysis and biological activities of endemic Achillea sieheana Stapf from Türkiye. . 2022; 1796 - 1804. 10.29228/jrp.270
IEEE DİKPINAR T,Göger F,Bitis L "LC-MS/MS analysis and biological activities of endemic Achillea sieheana Stapf from Türkiye." , ss.1796 - 1804, 2022. 10.29228/jrp.270
ISNAD DİKPINAR, TUĞÇE vd. "LC-MS/MS analysis and biological activities of endemic Achillea sieheana Stapf from Türkiye". (2022), 1796-1804. https://doi.org/10.29228/jrp.270
APA DİKPINAR T, Göger F, Bitis L (2022). LC-MS/MS analysis and biological activities of endemic Achillea sieheana Stapf from Türkiye. Journal of research in pharmacy (online), 26(6), 1796 - 1804. 10.29228/jrp.270
Chicago DİKPINAR TUĞÇE,Göger Fatih,Bitis Leyla LC-MS/MS analysis and biological activities of endemic Achillea sieheana Stapf from Türkiye. Journal of research in pharmacy (online) 26, no.6 (2022): 1796 - 1804. 10.29228/jrp.270
MLA DİKPINAR TUĞÇE,Göger Fatih,Bitis Leyla LC-MS/MS analysis and biological activities of endemic Achillea sieheana Stapf from Türkiye. Journal of research in pharmacy (online), vol.26, no.6, 2022, ss.1796 - 1804. 10.29228/jrp.270
AMA DİKPINAR T,Göger F,Bitis L LC-MS/MS analysis and biological activities of endemic Achillea sieheana Stapf from Türkiye. Journal of research in pharmacy (online). 2022; 26(6): 1796 - 1804. 10.29228/jrp.270
Vancouver DİKPINAR T,Göger F,Bitis L LC-MS/MS analysis and biological activities of endemic Achillea sieheana Stapf from Türkiye. Journal of research in pharmacy (online). 2022; 26(6): 1796 - 1804. 10.29228/jrp.270
IEEE DİKPINAR T,Göger F,Bitis L "LC-MS/MS analysis and biological activities of endemic Achillea sieheana Stapf from Türkiye." Journal of research in pharmacy (online), 26, ss.1796 - 1804, 2022. 10.29228/jrp.270
ISNAD DİKPINAR, TUĞÇE vd. "LC-MS/MS analysis and biological activities of endemic Achillea sieheana Stapf from Türkiye". Journal of research in pharmacy (online) 26/6 (2022), 1796-1804. https://doi.org/10.29228/jrp.270
Sayfa Oluşturulma Tarihi
24-04-2024 7:29

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