Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds

Özlem SAÇAN, (İstanbul Üniversitesi, Mühendislik Fakültesi, Kimya Mühendisliği Bölümü, İstanbul, Türkiye)
Emine Yıldız TURHAN (İstanbul Üniversitesi, Mühendislik Fakültesi, Kimya Mühendisliği Bölümü, İstanbul, Türkiye)
IUFS Journal of Biology
1 0
Yıl: 2014 Cilt: 73 Sayı: 2 Sayfa Aralığı: 47 - 52 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds

Öz:
Lipoksijenazlar (LOXs, linoleat: oksijen redüktaz, E.C.1.13.11.12) hem içermeyen, demir içeren dioksijenaz ailesidir. Lipoksijenazlar, artrit, astım, kalp damar, böbrek, deri ve alerjik hastalıklar, nörodejeneratif hastalıklar, kanser ve metabolik sendrom gibi çeşitli inflamasyon ile ilişkili hastalıklar ile ilgilidir. Bu çalışmada, farklı bitkilerden hazırlanan etanollü ekstrelerin ve bazı kimyasal bileşiklerin sağlık alanında önemli bir alana sahip olan LOX aktivitesi üzerine inhibe edici etkileri incelenmiştir. Çalışmada kullanılan tüm bitki ekstreleri ve kimyasal maddelerin LOX inhibitör etkisine sahip olduğu belirlenmiştir. Bitki ekstreleri ve kimyasal bileşiklerin enzim inhibitör aktiviteleri, doza bağlı olarak artmaktadır. Bu çalışmadan elde edilen sonuçlara göre, incelenen bitki ekstreleri ve bazı kimyasal bileşikler antiinflamatuar tedavide yeni bir potansiyel kaynak olabilirler.
Anahtar Kelime:

Konular: Biyoloji

Bazı Bitki Ekstreleri ve Kimyasal Bileşiklerin Lipoksijenaz İnhibitör Aktiviteleri

Öz:
Lipoxygenases (LOXs, linoleate: oxygen reductase, E.C. 1.13.11.12) are a family of non-heme ironcontaining dioxygenases. LOXs are associated with several inflammation-related diseases such as arthritis, asthma, cardiovascular, kidney, skin and allergic diseases, neurodegenerative disorders, cancer and metabolic syndrome. In this study, the inhibitory effects of ethanolic extracts prepared from 12 different plants and 12 different chemical compounds were investigated on the activity of LOX which has an important value in the health area. All the plant extracts and chemical substances used in our study showed LOX inhibitory effect. The enzyme inhibitory activities of the extracts and chemical compounds were increasing in a dose-dependent manner. The results obtained in the present study indicate that plant extracts and chemical compounds examined can be a potential source of novel antiinflammatory therapeutics.
Anahtar Kelime:

Konular: Biyoloji
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA SAÇAN O, TURHAN E (2014). Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds. , 47 - 52.
Chicago SAÇAN OZLEM,TURHAN Emine Yıldız Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds. (2014): 47 - 52.
MLA SAÇAN OZLEM,TURHAN Emine Yıldız Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds. , 2014, ss.47 - 52.
AMA SAÇAN O,TURHAN E Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds. . 2014; 47 - 52.
Vancouver SAÇAN O,TURHAN E Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds. . 2014; 47 - 52.
IEEE SAÇAN O,TURHAN E "Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds." , ss.47 - 52, 2014.
ISNAD SAÇAN, OZLEM - TURHAN, Emine Yıldız. "Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds". (2014), 47-52.
APA SAÇAN O, TURHAN E (2014). Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds. IUFS Journal of Biology, 73(2), 47 - 52.
Chicago SAÇAN OZLEM,TURHAN Emine Yıldız Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds. IUFS Journal of Biology 73, no.2 (2014): 47 - 52.
MLA SAÇAN OZLEM,TURHAN Emine Yıldız Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds. IUFS Journal of Biology, vol.73, no.2, 2014, ss.47 - 52.
AMA SAÇAN O,TURHAN E Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds. IUFS Journal of Biology. 2014; 73(2): 47 - 52.
Vancouver SAÇAN O,TURHAN E Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds. IUFS Journal of Biology. 2014; 73(2): 47 - 52.
IEEE SAÇAN O,TURHAN E "Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds." IUFS Journal of Biology, 73, ss.47 - 52, 2014.
ISNAD SAÇAN, OZLEM - TURHAN, Emine Yıldız. "Lipoxygenase Inhibitory Activities of Some Plant Extracts and Chemical Compounds". IUFS Journal of Biology 73/2 (2014), 47-52.
Sayfa Oluşturulma Tarihi
22-04-2024 21:40

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