Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract

Umay GÜVEN, (Çukurova Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, Adana, Türkiye)
Yusuf YAKUT, (Çukurova Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, Adana, Türkiye)
Nurdan ÇAKIR, (Çukurova Üniversitesi, Eczacılık Fakültesi, Farmasötik Botanik Anabilim Dalı, Adana, Türkiye)
Serpil DEMİRCİ KAYIRAN (Çukurova Üniversitesi, Eczacılık Fakültesi, Farmasötik Botanik Anabilim Dalı, Adana, Türkiye)
Istanbul Journal of Pharmacy
12 0
Yıl: 2023 Cilt: 53 Sayı: 1 Sayfa Aralığı: 27 - 38 Metin Dili: İngilizce DOI: 10.26650/IstanbulJPharm.2023.1066211 İndeks Tarihi: 30-05-2023

Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract

Öz:
Background and Aims: Sambucus ebulus L. has been used to treat inflammation-related gastrointestinal disorders, influenza, kidney ailments, lung diseases, rheumatoid arthritis, and snake and insect bites. Our study provides important ethnobotanical information about S. ebulus with the aim of developing a formulation with increased extract bioavailability, diminished side effects, and easy drug loading and dose adjustment as an effective local therapy for dermatologic diseases. Methods: Twelve in-situ gels with S. ebulus were prepared as antifungal treatments in accordance with the cold method and formulated using poloxamer and hydroxypropyl methylcellulose (HPMC). The formulations were characterized in terms of pH, gelling capacity, swelling degree, spreadability, and rheological properties. Results: Among the prepared in situ gel formulations, the Poloxamer 407 and 407-HPMC mixtures of P14H1 and P15 demonstrated acceptable gelation temperatures for dermal use. Conclusion: Thermosensitive in-situ gels containing S. ebulus may be a viable alternative for treating fungal diseases.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA GÜVEN U, Yakut Y, Çakır N, Demirci S (2023). Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract. , 27 - 38. 10.26650/IstanbulJPharm.2023.1066211
Chicago GÜVEN UMAY MERVE,Yakut Yusuf,Çakır Nurdan,Demirci Serpil Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract. (2023): 27 - 38. 10.26650/IstanbulJPharm.2023.1066211
MLA GÜVEN UMAY MERVE,Yakut Yusuf,Çakır Nurdan,Demirci Serpil Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract. , 2023, ss.27 - 38. 10.26650/IstanbulJPharm.2023.1066211
AMA GÜVEN U,Yakut Y,Çakır N,Demirci S Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract. . 2023; 27 - 38. 10.26650/IstanbulJPharm.2023.1066211
Vancouver GÜVEN U,Yakut Y,Çakır N,Demirci S Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract. . 2023; 27 - 38. 10.26650/IstanbulJPharm.2023.1066211
IEEE GÜVEN U,Yakut Y,Çakır N,Demirci S "Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract." , ss.27 - 38, 2023. 10.26650/IstanbulJPharm.2023.1066211
ISNAD GÜVEN, UMAY MERVE vd. "Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract". (2023), 27-38. https://doi.org/10.26650/IstanbulJPharm.2023.1066211
APA GÜVEN U, Yakut Y, Çakır N, Demirci S (2023). Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract. Istanbul Journal of Pharmacy, 53(1), 27 - 38. 10.26650/IstanbulJPharm.2023.1066211
Chicago GÜVEN UMAY MERVE,Yakut Yusuf,Çakır Nurdan,Demirci Serpil Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract. Istanbul Journal of Pharmacy 53, no.1 (2023): 27 - 38. 10.26650/IstanbulJPharm.2023.1066211
MLA GÜVEN UMAY MERVE,Yakut Yusuf,Çakır Nurdan,Demirci Serpil Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract. Istanbul Journal of Pharmacy, vol.53, no.1, 2023, ss.27 - 38. 10.26650/IstanbulJPharm.2023.1066211
AMA GÜVEN U,Yakut Y,Çakır N,Demirci S Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract. Istanbul Journal of Pharmacy. 2023; 53(1): 27 - 38. 10.26650/IstanbulJPharm.2023.1066211
Vancouver GÜVEN U,Yakut Y,Çakır N,Demirci S Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract. Istanbul Journal of Pharmacy. 2023; 53(1): 27 - 38. 10.26650/IstanbulJPharm.2023.1066211
IEEE GÜVEN U,Yakut Y,Çakır N,Demirci S "Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract." Istanbul Journal of Pharmacy, 53, ss.27 - 38, 2023. 10.26650/IstanbulJPharm.2023.1066211
ISNAD GÜVEN, UMAY MERVE vd. "Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract". Istanbul Journal of Pharmacy 53/1 (2023), 27-38. https://doi.org/10.26650/IstanbulJPharm.2023.1066211
Sayfa Oluşturulma Tarihi
24-04-2024 7:34

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