Investigation of Galectin-3 Levels of Endometriosis Patients According to Stages

DEMOKAN, SEMRA; Mısır, Sema; YILDIZ, Çağlar; OKŞAŞOĞLU, BUĞRA; AKKUS, Armagan; Yaylim, Ilhan; Kızılgedik, Dilşan Fulya; hepokur, ceylan

Investigation of Galectin-3 Levels of Endometriosis Patients According to Stages

Dilşan Fulya Kızılgedik, (Department of Biochemistry, Faculty of Pharmacy, Sivas Cumhuriyet University, Sivas, Turkiye)

Armağan CANER, (Department of Biophysics, Faculty of Medicine, Erciyes University, Kayseri, Turkiye)

Çağlar YILDIZ, (Department of Obstetrics and Gynecology, Faculty of Medicine, Sivas Cumhuriyet University, Sivas, Turkiye)

BUĞRA OKŞAŞOĞLU, (Department of Obstetrics and Gynecology, Hospital of Numune, Sivas, Turkiye)

Sema MISIR, (Department of Biochemistry, Faculty of Pharmacy, Sivas Cumhuriyet University, Sivas, Turkiye)

İlhan YAYLIM, (Department of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkiye)

Semra DEMOKAN, (Department of Basic Oncology, Institute of Oncology, Istanbul University, Istanbul, Turkiye)

Ceylan HEPOKUR (Department of Biochemistry, Faculty of Pharmacy, Sivas Cumhuriyet University, Sivas, Turkiye)

EXPERIMED

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Yıl: 2023 Cilt: 13 Sayı: 1 Sayfa Aralığı: 15 - 20 Metin Dili: İngilizce İndeks Tarihi: 30-05-2023

Investigation of Galectin-3 Levels of Endometriosis Patients According to Stages

Öz:

Objective: Endometriosis is a gynecological disease associated with chronic pelvic inflammation, pain, and infertility. Galectin-3 (Gal-3) is a protein that can bind to β-galactosides, which plays an important role in different biological processes according to the stages of the disease in patients with endometriosis. This study aimed to elucidate the importance of Gal-3 in endometriosis, to reveal its potential power as a non-invasive diagnostic biomarker in disease etiopathogenesis. Materials and Methods: The serum concentration of Gal-3 and cancer antigen 125 (CA-125) from whole blood were measured using enzyme-linked immuno sorbent assay (ELISA) and an auto-analyzer, respectively. Gal-3 expression was determined by quantitative real-time polymerase chain reaction (qRT-PCR) from peripheral blood. Results: We found significant differences for Gal-3 expression levels between the endometriosis and control groups (p <0.05). Gal-3 levels in the serum of women with endometriosis are also remarkably increased compared with the control group. Conclusion: Galectin-3 can play critical functions in the development and progression of endometriosis, so, further studies are needed in this area.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Kızılgedik D, AKKUS A, YILDIZ Ç, OKŞAŞOĞLU B, Mısır S, Yaylim I, DEMOKAN S, hepokur c (2023). Investigation of Galectin-3 Levels of Endometriosis Patients According to Stages. , 15 - 20.
Chicago	Kızılgedik Dilşan Fulya,AKKUS Armagan,YILDIZ Çağlar,OKŞAŞOĞLU BUĞRA,Mısır Sema,Yaylim Ilhan,DEMOKAN SEMRA,hepokur ceylan Investigation of Galectin-3 Levels of Endometriosis Patients According to Stages. (2023): 15 - 20.
MLA	Kızılgedik Dilşan Fulya,AKKUS Armagan,YILDIZ Çağlar,OKŞAŞOĞLU BUĞRA,Mısır Sema,Yaylim Ilhan,DEMOKAN SEMRA,hepokur ceylan Investigation of Galectin-3 Levels of Endometriosis Patients According to Stages. , 2023, ss.15 - 20.
AMA	Kızılgedik D,AKKUS A,YILDIZ Ç,OKŞAŞOĞLU B,Mısır S,Yaylim I,DEMOKAN S,hepokur c Investigation of Galectin-3 Levels of Endometriosis Patients According to Stages. . 2023; 15 - 20.
Vancouver	Kızılgedik D,AKKUS A,YILDIZ Ç,OKŞAŞOĞLU B,Mısır S,Yaylim I,DEMOKAN S,hepokur c Investigation of Galectin-3 Levels of Endometriosis Patients According to Stages. . 2023; 15 - 20.
IEEE	Kızılgedik D,AKKUS A,YILDIZ Ç,OKŞAŞOĞLU B,Mısır S,Yaylim I,DEMOKAN S,hepokur c "Investigation of Galectin-3 Levels of Endometriosis Patients According to Stages." , ss.15 - 20, 2023.
ISNAD	Kızılgedik, Dilşan Fulya vd. "Investigation of Galectin-3 Levels of Endometriosis Patients According to Stages". (2023), 15-20.

APA	Kızılgedik D, AKKUS A, YILDIZ Ç, OKŞAŞOĞLU B, Mısır S, Yaylim I, DEMOKAN S, hepokur c (2023). Investigation of Galectin-3 Levels of Endometriosis Patients According to Stages. EXPERIMED, 13(1), 15 - 20.
Chicago	Kızılgedik Dilşan Fulya,AKKUS Armagan,YILDIZ Çağlar,OKŞAŞOĞLU BUĞRA,Mısır Sema,Yaylim Ilhan,DEMOKAN SEMRA,hepokur ceylan Investigation of Galectin-3 Levels of Endometriosis Patients According to Stages. EXPERIMED 13, no.1 (2023): 15 - 20.
MLA	Kızılgedik Dilşan Fulya,AKKUS Armagan,YILDIZ Çağlar,OKŞAŞOĞLU BUĞRA,Mısır Sema,Yaylim Ilhan,DEMOKAN SEMRA,hepokur ceylan Investigation of Galectin-3 Levels of Endometriosis Patients According to Stages. EXPERIMED, vol.13, no.1, 2023, ss.15 - 20.
AMA	Kızılgedik D,AKKUS A,YILDIZ Ç,OKŞAŞOĞLU B,Mısır S,Yaylim I,DEMOKAN S,hepokur c Investigation of Galectin-3 Levels of Endometriosis Patients According to Stages. EXPERIMED. 2023; 13(1): 15 - 20.
Vancouver	Kızılgedik D,AKKUS A,YILDIZ Ç,OKŞAŞOĞLU B,Mısır S,Yaylim I,DEMOKAN S,hepokur c Investigation of Galectin-3 Levels of Endometriosis Patients According to Stages. EXPERIMED. 2023; 13(1): 15 - 20.
IEEE	Kızılgedik D,AKKUS A,YILDIZ Ç,OKŞAŞOĞLU B,Mısır S,Yaylim I,DEMOKAN S,hepokur c "Investigation of Galectin-3 Levels of Endometriosis Patients According to Stages." EXPERIMED, 13, ss.15 - 20, 2023.
ISNAD	Kızılgedik, Dilşan Fulya vd. "Investigation of Galectin-3 Levels of Endometriosis Patients According to Stages". EXPERIMED 13/1 (2023), 15-20.