Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue

KURTEL, Hızır; AYCI, Nurdan BÜLBÜL; ÖZDEMİR-KUMRAL, Zarife Nig r; ÇİLİNGİR KAYA, Özlem Tuğçe

doi:10.29228/jrp.356

Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue

Zarife Nig r ÖZDEMİR-KUMRAL, (Marmara Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, İstanbul, Türkiye)

Nurdan BÜLBÜL AYCI, (Tekirdağ Namık Kemal Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Tekirdağ, Türkiye)

Özlem Tuğçe ÇİLİNGİR KAYA, (Marmara Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, İstanbul, Türkiye)

Hızır KURTEL (Marmara Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, İstanbul, Türkiye)

Journal of research in pharmacy (online)

3 0

Yıl: 2023 Cilt: 27 Sayı: 2 Sayfa Aralığı: 733 - 752 Metin Dili: İngilizce DOI: 10.29228/jrp.356 İndeks Tarihi: 31-05-2023

Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue

Öz:

The aim of the study is to explain the possible effects of exercise-induced novel peptide irisin on endothelial function accompanied by perivascular adipose tissue (PVAT) in aortas of both natural aging and D- galactose (D-Gal) aging mimetic rats. Female Sprague-Dawley rats were randomly divided into 6 groups (n=10/per group): sedentary young group (SY), exercised young group (EY), sedentary aging group (SA), exercised aging group (EA), sedentary D-Gal (300 mg/kg/day, i.p., 9 weeks) induced aging group (S+D-Gal), exercised D-Gal induced aging group (E+D-Gal). Cardiac and aortic samples were collected for biochemical and histopathological examinations. The aortas were taken for contractile response studies in the absence or presence of perivascular adipose tissue (PVAT-/+). The levels of irisin in both plasma and PVAT were detected. Regardless of the models the vaso-relaxant effects of irisin were shown alone and age-related vascular dysfunction has also been recorded compared to the SY group these age- related impaired irisin responses were found to be improved by regular exercise. The plasma and PVAT irisin levels were decreased by aging and exercise reversed this decrement which is verified by the immune expression of irisin in aortic and PVAT tissues. Our results show the differences in vascular function and PVAT in aging and the contribution of PVAT to the response of irisin with exercise in two different aging models.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÖZDEMİR-KUMRAL Z, AYCI N, ÇİLİNGİR KAYA Ö, KURTEL H (2023). Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue. , 733 - 752. 10.29228/jrp.356
Chicago	ÖZDEMİR-KUMRAL Zarife Nig r,AYCI Nurdan BÜLBÜL,ÇİLİNGİR KAYA Özlem Tuğçe,KURTEL Hızır Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue. (2023): 733 - 752. 10.29228/jrp.356
MLA	ÖZDEMİR-KUMRAL Zarife Nig r,AYCI Nurdan BÜLBÜL,ÇİLİNGİR KAYA Özlem Tuğçe,KURTEL Hızır Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue. , 2023, ss.733 - 752. 10.29228/jrp.356
AMA	ÖZDEMİR-KUMRAL Z,AYCI N,ÇİLİNGİR KAYA Ö,KURTEL H Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue. . 2023; 733 - 752. 10.29228/jrp.356
Vancouver	ÖZDEMİR-KUMRAL Z,AYCI N,ÇİLİNGİR KAYA Ö,KURTEL H Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue. . 2023; 733 - 752. 10.29228/jrp.356
IEEE	ÖZDEMİR-KUMRAL Z,AYCI N,ÇİLİNGİR KAYA Ö,KURTEL H "Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue." , ss.733 - 752, 2023. 10.29228/jrp.356
ISNAD	ÖZDEMİR-KUMRAL, Zarife Nig r vd. "Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue". (2023), 733-752. https://doi.org/10.29228/jrp.356

APA	ÖZDEMİR-KUMRAL Z, AYCI N, ÇİLİNGİR KAYA Ö, KURTEL H (2023). Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue. Journal of research in pharmacy (online), 27(2), 733 - 752. 10.29228/jrp.356
Chicago	ÖZDEMİR-KUMRAL Zarife Nig r,AYCI Nurdan BÜLBÜL,ÇİLİNGİR KAYA Özlem Tuğçe,KURTEL Hızır Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue. Journal of research in pharmacy (online) 27, no.2 (2023): 733 - 752. 10.29228/jrp.356
MLA	ÖZDEMİR-KUMRAL Zarife Nig r,AYCI Nurdan BÜLBÜL,ÇİLİNGİR KAYA Özlem Tuğçe,KURTEL Hızır Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue. Journal of research in pharmacy (online), vol.27, no.2, 2023, ss.733 - 752. 10.29228/jrp.356
AMA	ÖZDEMİR-KUMRAL Z,AYCI N,ÇİLİNGİR KAYA Ö,KURTEL H Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue. Journal of research in pharmacy (online). 2023; 27(2): 733 - 752. 10.29228/jrp.356
Vancouver	ÖZDEMİR-KUMRAL Z,AYCI N,ÇİLİNGİR KAYA Ö,KURTEL H Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue. Journal of research in pharmacy (online). 2023; 27(2): 733 - 752. 10.29228/jrp.356
IEEE	ÖZDEMİR-KUMRAL Z,AYCI N,ÇİLİNGİR KAYA Ö,KURTEL H "Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue." Journal of research in pharmacy (online), 27, ss.733 - 752, 2023. 10.29228/jrp.356
ISNAD	ÖZDEMİR-KUMRAL, Zarife Nig r vd. "Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue". Journal of research in pharmacy (online) 27/2 (2023), 733-752. https://doi.org/10.29228/jrp.356