Risk Factor Mapping Associated with Breast Cancer: A National-Based Study

bademler, süleyman; Karanlik, Hasan; Ilhan, Burak; DİŞÇİ, RIAN

doi:10.14744/cm.2022.47855

Risk Factor Mapping Associated with Breast Cancer: A National-Based Study

Burak ILHAN, (İstanbul Üniversitesi, Tıp Fakültesi, Cerrahi Anabilim Dalı, İstanbul, Türkiye)

Süleyman BADEMLER, (İstanbul Üniversitesi, Onkoloji Enstitüsü, Cerrahi Anabilim Dalı, İstanbul, Türkiye)

Rian DİŞÇİ, (İstanbul Üniversitesi, Tıp Fakültesi, Biyoistatistik Anabilim Dalı, İstanbul, Türkiye)

Hasan KARANLIK (İstanbul Üniversitesi, Onkoloji Enstitüsü, Cerrahi Anabilim Dalı, İstanbul, Türkiye)

Comprehensive medicine

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Yıl: 2023 Cilt: 15 Sayı: 1 Sayfa Aralığı: 27 - 34 Metin Dili: İngilizce DOI: 10.14744/cm.2022.47855 İndeks Tarihi: 31-05-2023

Risk Factor Mapping Associated with Breast Cancer: A National-Based Study

Öz:

Objective: Many risk factors have been associated with breast cancer (BC) in years. The objective of our study was to predict possible risk factors related to BC and to contribute national and global screening programs. Materials and Methods: A case–control study was created among women who were examined at the department of Surgery, Oncology Institute, Istanbul University, between January 2009 and December 2015. The patients were divided into two groups as 1006 women with BC diagnosis and and 3439 women witout BC. A database was formed by questioning demographics, clinical characteristics of patients, and the possible factors that could be associated with BC were analyzed. Results: According to the results of the study, high education level and being postmenopausal were found to be closely related to BC (p<0.0001). In addition, as having history of smoking (Odds Ratio [OR] 2.3; 95% confidence interval [CI]: 1.2–4.7, p=0.02), as having first-degree relative with BC (OR 2.4; 95% CI: 1.1–5.3, p=0.03), as having a member in family with BC under the age of 50 (OR 3.1; 95% CI 1.9–8.1, p=0.005), as being high body mass indexed-patient (OR 1.2; 95% CI: 1.1–1.3, p=0.001), such as not giving birth (OR 2.1; 95% CI: 1.2–4.6, p=0.01), and used postmenopausal hormone replacement therapy (OR 2.88; 95% CI: 0.02–2.4, p=0.049) were identified as important risk factors associated with BC. Conclusion: This present study has determined national-based significant risk factors associated with BC. We can surely extrapolate that this study is one of the important briefs to support national and also worldwide risk models and screening programs.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, et al. Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Res 2013;15:R92.
2. Colditz GA, Bohlke K. Priorities for the primary prevention of breast cancer. CA Cancer J Clin 2014;64:186–94.
3. Tuncer M. Significance of cancer in Turkey, the burden of disease and cancer control policies. In: Tuncer M, editor. Cancer Control in Turkey. Ankara: Health Ministry Publication; 2008. p. 5–9.
4. Özmen V, Özmen T, Doğru V. Breast cancer in Turkey; an analysis of 20.000 patients with breast cancer. Eur J Breast Health 2019;15:141–6. Erratum in: Eur J Breast Health 2019;15:276.
5. Terry MB, Zhang FF, Kabat G, Britton JA, Teitelbaum SL, Neugut AI, et al. Lifetime alcohol intake and breast cancer risk. Ann Epidemiol 2006;16:230–40.
6. Suzuki R, Ye W, Rylander-Rudqvist T, Saji S, Colditz GA, Wolk A. Alcohol and postmenopausal breast cancer risk defined by estrogen and progesterone receptor status: A prospective cohort study. J Natl Cancer Inst 2005;97:1601–8.
7. Mahoney MC, Bevers T, Linos E, Willett WC. Opportunities and strategies for breast cancer prevention through risk reduction. CA Cancer J Clin 2008;58:347–71.
8. Howard RA, Leitzmann MF, Linet MS, Freedman DM. Physical activity and breast cancer risk among pre- and postmenopausal women in the U.S. Radiologic Technologists cohort. Cancer Causes Control 2009;20:323–33.
9. Tehard B, Friedenreich CM, Oppert JM, Clavel-Chapelon F. Effect of physical activity on women at increased risk of breast cancer: Results from the E3N cohort study. Cancer Epidemiol Biomarkers Prev 2006;15:57–64.
10. Bernstein L, Patel AV, Ursin G, Sullivan-Halley J, Press MF, Deapen D, et al. Lifetime recreational exercise activity and breast cancer risk among black women and white women. J Natl Cancer Inst 2005;97:1671–9.
11. Collaborative Group on Hormonal Factors in Breast Cancer. Familial breast cancer: Collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease. Lancet 2001;358:1389–99.
12. Ellisen LW, Haber DA. Hereditary breast cancer. Annu Rev Med 1998;49:425–36. Erratum in: Annu Rev Med 1999;50:582.
13. NCCN. Clinical practice guidelines in oncology (NCCN Guidelines®). Genetic/Familial High-Risk Assessment: Breast and Ovarian. Version 3.2019. Available at: https://www2.tri-kobe.org/nccn/guideline/gynecological/ english/genetic_familial.pdf. Accessed Jan 24, 2023.
14. Koçak S, Çelik L, Özbaş S, Dizbay Sak S, Tükün A, Yalçın B. Risk factors in breast cancer, risk assessment and prevention: 2010 İstanbul Consensus meeeting report. J Breast Health [Article in Turkish] 2011;7:47–67.
15. Bluman LG, Rimer BK, Berry DA, Borstelmann N, Iglehart JD, Regan K, et al. Attitudes, knowledge, and risk perceptions of women with breast and/or ovarian cancer considering testing for BRCA1 and BRCA2. J Clin Oncol 1999;17:1040–6.
16. Berry DA, Iversen ES Jr, Gudbjartsson DF, Hiller EH, Garber JE, Peshkin BN, et al. BRCAPRO validation, sensitivity of genetic testing of BRCA1/ BRCA2, and prevalence of other breast cancer susceptibility genes. J Clin Oncol 2002;20:2701–12.
17. Hsieh CC, Trichopoulos D, Katsouyanni K, Yuasa S. Age at menarche, age at menopause, height and obesity as risk factors for breast cancer: associations and interactions in an international case-control study. Int J Cancer 1990;46:796–800.
18. Colditz GA, Rosner B. Cumulative risk of breast cancer to age 70 years according to risk factor status: Data from the Nurses' Health Study. Am J Epidemiol 2000;152:950–64.
19. Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and hormone replacement therapy: Collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer. Lancet 1997;350:1047–59. Erratum in: Lancet 1997;350:1484.
20. Rosner B, Colditz GA, Willett WC. Reproductive risk factors in a prospective study of breast cancer: The Nurses' Health Study. Am J Epidemiol 1994;139:819–35.
21. Braaten T, Weiderpass E, Kumle M, Adami HO, Lund E. Education and risk of breast cancer in the Norwegian-Swedish women's lifestyle and health cohort study. Int J Cancer 2004;110:579–83.
22. Colditz GA, Rosner BA, Speizer FE. Risk factors for breast cancer according to family history of breast cancer. For the Nurses' Health Study Research Group. J Natl Cancer Inst 1996;88:365–71.
23. Cui Y, Miller AB, Rohan TE. Cigarette smoking and breast cancer risk: Update of a prospective cohort study. Breast Cancer Res Treat 2006;100:293–9.
24. Ozmen V, Ozcinar B, Karanlik H, Cabioglu N, Tukenmez M, Disci R, et al. Breast cancer risk factors in Turkish women--a University Hospital based nested case control study. World J Surg Oncol 2009;7:37.
25. Velentgas P, Daling JR. Risk factors for breast cancer in younger women. J Natl Cancer Inst Monogr 1994;16:15–24.
26. McPherson K, Steel CM, Dixon JM. ABC of breast diseases. Breast cancer- epidemiology, risk factors, and genetics. BMJ 2000;321:624–8.
27. Helmrich SP, Shapiro S, Rosenberg L, Kaufman DW, Slone D, Bain C, et al. Risk factors for breast cancer. Am J Epidemiol 1983;117:35–45.
28. Negri E, Braga C, La Vecchia C, Levi F, Talamini R, Franceschi S. Lactation and the risk of breast cancer in an Italian population. Int J Cancer 1996;67:161–4.
29. Tavani A, Braga C, La Vecchia C, Negri E, Russo A, Franceschi S. Attributable risks for breast cancer in Italy: education, family history and reproductive and hormonal factors. Int J Cancer 1997;70:159–63.
30. Ha M, Mabuchi K, Sigurdson AJ, Freedman DM, Linet MS, Doody MM, et al. Smoking cigarettes before first childbirth and risk of breast cancer. Am J Epidemiol 2007;166:55–61.
31. Magnusson C, Wedrén S, Rosenberg LU. Cigarette smoking and breast cancer risk: a population-based study in Sweden. Br J Cancer 2007;97:1287–90.
32. Gram IT, Braaten T, Terry PD, Sasco AJ, Adami HO, Lund E, et al. Breast cancer risk among women who start smoking as teenagers. Cancer Epidemiol Biomarkers Prev 2005;14:61–6.
33. Terry PD, Miller AB, Rohan TE. Cigarette smoking and breast cancer risk: A long latency period? Int J Cancer 2002;100:723–8.
34. Ceber E, Sogukpinar N, Mermer G, Aydemir G. Nutrition, lifestyle, and breast cancer risk among Turkish women. Nutr Cancer 2005;53:152–9.
35. Baron JA, La Vecchia C, Levi F. The antiestrogenic effect of cigarette smoking in women. Am J Obstet Gynecol 1990;162:502–14.
36. Tsuchiya M, Iwasaki M, Otani T, Nitadori J, Goto K, Nishiwaki Y, et al. Breast cancer in first-degree relatives and risk of lung cancer: Assessment of the existence of gene sex interactions. Jpn J Clin Oncol 2007;37:419–23.
37. Lipworth L. Epidemiology of breast cancer. Eur J Cancer Prev 1995;4:7– 30.
38. Cold S, Hansen S, Overvad K, Rose C. A woman's build and the risk of breast cancer. Eur J Cancer 1998;34:1163–74.
39. Lee K, Kruper L, Dieli-Conwright CM, Mortimer JE. The impact of obesity on breast cancer diagnosis and treatment. Curr Oncol Rep 2019;21:41.
40. Lawlor DA, Smith GD, Ebrahim S. Hyperinsulinaemia and increased risk of breast cancer: Findings from the British Women's Heart and Health Study. Cancer Causes Control 2004;15:267–75.
41. Pike MC, Krailo MD, Henderson BE, Casagrande JT, Hoel DG. 'Hormonal' risk factors, 'breast tissue age' and the age-incidence of breast cancer. Nature 1983;303:767–70.
42. Shantakumar S, Terry MB, Teitelbaum SL, Britton JA, Millikan RC, Moorman PG, et al. Reproductive factors and breast cancer risk among older women. Breast Cancer Res Treat 2007;102:365–74.
43. Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and breastfeeding: Collaborative reanalysis of individual data from 47 epidemiological studies in 30 countries, including 50302 women with breast cancer and 96973 women without the disease. Lancet 2002;360:187–95.
44. Lee SY, Kim MT, Kim SW, Song MS, Yoon SJ. Effect of lifetime lactation on breast cancer risk: A Korean women's cohort study. Int J Cancer 2003;105:390–3.
45. Enger SM, Ross RK, Paganini-Hill A, Bernstein L. Breastfeeding experience and breast cancer risk among postmenopausal women. Cancer Epidemiol Biomarkers Prev 1998;7:365–9.
46. Kim Y, Choi JY, Lee KM, Park SK, Ahn SH, Noh DY, et al. Dose-dependent protective effect of breast-feeding against breast cancer among ever-lactated women in Korea. Eur J Cancer Prev 2007;16:124–9.
47. Reeves GK, Kan SW, Key T, Tjønneland A, Olsen A, Overvad K, et al. Breast cancer risk in relation to abortion: Results from the EPIC study. Int J Cancer 2006;119:1741–5.
48. Michels KB, Xue F, Colditz GA, Willett WC. Induced and spontaneous abortion and incidence of breast cancer among young women: A prospective cohort study. Arch Intern Med 2007;167:814–20.
49. Li CI, Malone KE, Porter PL, Weiss NS, Tang MT, Cushing-Haugen KL, et al. Relationship between long durations and different regimens of hormone therapy and risk of breast cancer. JAMA 2003;289:3254–63.
50. Newcomb PA, Titus-Ernstoff L, Egan KM, Trentham-Dietz A, Baron JA, Storer BE, et al. Postmenopausal estrogen and progestin use in relation to breast cancer risk. Cancer Epidemiol Biomarkers Prev 2002;11:593– 600.
51. Fentiman IS. 20. Oral contraceptives, hormone replacement therapy and breast cancer. Int J Clin Pract 2002;56:755–9.
52. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, et al; Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women's Health Initiative randomized controlled trial. JAMA 2002;288:321–33.
53. Malone KE, Daling JR, Weiss NS. Oral contraceptives in relation to breast cancer. Epidemiol Rev 1993;15:80–97.
54. Vessey M, Painter R. Oral contraceptive use and cancer. Findings in a large cohort study, 1968-2004. Br J Cancer 2006;95:385–9.

APA	Ilhan B, bademler s, DİŞÇİ R, Karanlik H (2023). Risk Factor Mapping Associated with Breast Cancer: A National-Based Study. , 27 - 34. 10.14744/cm.2022.47855
Chicago	Ilhan Burak,bademler süleyman,DİŞÇİ RIAN,Karanlik Hasan Risk Factor Mapping Associated with Breast Cancer: A National-Based Study. (2023): 27 - 34. 10.14744/cm.2022.47855
MLA	Ilhan Burak,bademler süleyman,DİŞÇİ RIAN,Karanlik Hasan Risk Factor Mapping Associated with Breast Cancer: A National-Based Study. , 2023, ss.27 - 34. 10.14744/cm.2022.47855
AMA	Ilhan B,bademler s,DİŞÇİ R,Karanlik H Risk Factor Mapping Associated with Breast Cancer: A National-Based Study. . 2023; 27 - 34. 10.14744/cm.2022.47855
Vancouver	Ilhan B,bademler s,DİŞÇİ R,Karanlik H Risk Factor Mapping Associated with Breast Cancer: A National-Based Study. . 2023; 27 - 34. 10.14744/cm.2022.47855
IEEE	Ilhan B,bademler s,DİŞÇİ R,Karanlik H "Risk Factor Mapping Associated with Breast Cancer: A National-Based Study." , ss.27 - 34, 2023. 10.14744/cm.2022.47855
ISNAD	Ilhan, Burak vd. "Risk Factor Mapping Associated with Breast Cancer: A National-Based Study". (2023), 27-34. https://doi.org/10.14744/cm.2022.47855

APA	Ilhan B, bademler s, DİŞÇİ R, Karanlik H (2023). Risk Factor Mapping Associated with Breast Cancer: A National-Based Study. Comprehensive medicine, 15(1), 27 - 34. 10.14744/cm.2022.47855
Chicago	Ilhan Burak,bademler süleyman,DİŞÇİ RIAN,Karanlik Hasan Risk Factor Mapping Associated with Breast Cancer: A National-Based Study. Comprehensive medicine 15, no.1 (2023): 27 - 34. 10.14744/cm.2022.47855
MLA	Ilhan Burak,bademler süleyman,DİŞÇİ RIAN,Karanlik Hasan Risk Factor Mapping Associated with Breast Cancer: A National-Based Study. Comprehensive medicine, vol.15, no.1, 2023, ss.27 - 34. 10.14744/cm.2022.47855
AMA	Ilhan B,bademler s,DİŞÇİ R,Karanlik H Risk Factor Mapping Associated with Breast Cancer: A National-Based Study. Comprehensive medicine. 2023; 15(1): 27 - 34. 10.14744/cm.2022.47855
Vancouver	Ilhan B,bademler s,DİŞÇİ R,Karanlik H Risk Factor Mapping Associated with Breast Cancer: A National-Based Study. Comprehensive medicine. 2023; 15(1): 27 - 34. 10.14744/cm.2022.47855
IEEE	Ilhan B,bademler s,DİŞÇİ R,Karanlik H "Risk Factor Mapping Associated with Breast Cancer: A National-Based Study." Comprehensive medicine, 15, ss.27 - 34, 2023. 10.14744/cm.2022.47855
ISNAD	Ilhan, Burak vd. "Risk Factor Mapping Associated with Breast Cancer: A National-Based Study". Comprehensive medicine 15/1 (2023), 27-34. https://doi.org/10.14744/cm.2022.47855