Objective: Tobacco consumption is a well-known cause of morbidity and mortality. Therefore, smoking cessation is a fundamental primary and secondary disease protection objective. This study aimed to implement a smoking cessation program for first- and second-degree relatives of inpatients hospitalized for smoking-related diseases. Methods: We planned to evaluate the effects of targeting relatives of hospitalized patients on the contemplation of smoking cessation. Participants who have a hospitalized relative in any of the Hacettepe University Hospital Internal Medicine, Oncology, or Cardiology clinics between February and April 2016 for a smoking-related disease were included in the study. The smoking status of the participants has been recorded and smokers were included in the cohort. Results: During the study period, 761 persons were inter- viewed in the clinics and it was found that 337 patient-relatives (44.2%) were smokers. A total of 332 participants who obtained inclusion criteria were informed about the smoking cessation program. A total of 159 individuals (47.9%) were approved to be referred to smoking cessation clinic. The mean age of par- ticipants who agreed to be included in the smoking cessation program was significantly lower than those who refused (41.8 ± 11.1 vs. 45.1 ± 13.8, P = .01). The education level of the partici- pants who agreed to be included in the smoking cessation pro- gram was significantly higher than those who refused (P = .009).Relatives of chronic obstructive pulmonary disease patients agreed to apply to the smoking cessation clinics more than any other disease group (P = .006). Conclusion: According to the results of this study, patient relatives can be considered as an important target group in smoking cessation programs.