Effect of Anakinra and Infliximab on Oxidative Stress and Caspase Activation in PTZ-Induced Acute Seizure in Rats

Taskiran, Ahmet Sevki; GÜNEŞ, Handan; YILDIZHAN, Kenan

doi:10.5505/ejm.2023.84669

Effect of Anakinra and Infliximab on Oxidative Stress and Caspase Activation in PTZ-Induced Acute Seizure in Rats

Kenan YILDIZHAN, (Van Yüzüncü Yıl Üniversitesi Tıp Fakültesi Biyofizik Anabilim Dalı, Van, Türkiye)

Handan GÜNEŞ, (Sivas Cumhuriyet Üniversitesi Tıp Fakültesi Fizyoloji Anabilim Dalı, Sivas, Türkiye)

Ahmet Şevki TAŞKIRAN (Sivas Cumhuriyet Üniversitesi Tıp Fakültesi Fizyoloji Anabilim Dalı, Sivas, Türkiye)

Eastern Journal of Medicine

2 0

Yıl: 2023 Cilt: 28 Sayı: 1 Sayfa Aralığı: 75 - 81 Metin Dili: İngilizce DOI: 10.5505/ejm.2023.84669 İndeks Tarihi: 06-06-2023

Effect of Anakinra and Infliximab on Oxidative Stress and Caspase Activation in PTZ-Induced Acute Seizure in Rats

Öz:

We aimed to examine the effects of Anakinra (AKR) and Infliximab (IFB) on increased oxidative stress (OS) and pro- apoptotic pathway parameters after an epileptic attack. The rats were divided into four groups; Control, pentylenetetrazol (PTZ), PTZ+Anakinra, and PTZ+Infliximab groups. AKR and IFB treatment was done 30 minutes after PTZ administration and rats were sacrificed after 24 hours. The acute epilepsy model we created with PTZ in the rats and seizure symptoms were evaluated using the Racine classification and the delay time to the first myoclonic jerk. We also examined the levels of total antioxidant status (TAS), total oxidative stress (TOS), neurotrophin brain -derived neurotrophic factor (BDNF), Caspase 3 and Caspase 9 in the cortex and hippocampus. Post -treatment of AKR and IFB decreased PTZ-induced OS in the cortex and hippocampus while TAS levels also increased. In addition, it was observed that AKR and IFB decreased the levels of BDNF, Caspase 3 and Caspase 9 compared to the PTZ group. These findings showed that AKR and IFB may be used as important therapeutic agents to inhibit OS and apoptosis mechanisms that may occur after PTZ-induced epileptic attacks.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	YILDIZHAN K, GÜNEŞ H, Taskiran A (2023). Effect of Anakinra and Infliximab on Oxidative Stress and Caspase Activation in PTZ-Induced Acute Seizure in Rats. , 75 - 81. 10.5505/ejm.2023.84669
Chicago	YILDIZHAN Kenan,GÜNEŞ Handan,Taskiran Ahmet Sevki Effect of Anakinra and Infliximab on Oxidative Stress and Caspase Activation in PTZ-Induced Acute Seizure in Rats. (2023): 75 - 81. 10.5505/ejm.2023.84669
MLA	YILDIZHAN Kenan,GÜNEŞ Handan,Taskiran Ahmet Sevki Effect of Anakinra and Infliximab on Oxidative Stress and Caspase Activation in PTZ-Induced Acute Seizure in Rats. , 2023, ss.75 - 81. 10.5505/ejm.2023.84669
AMA	YILDIZHAN K,GÜNEŞ H,Taskiran A Effect of Anakinra and Infliximab on Oxidative Stress and Caspase Activation in PTZ-Induced Acute Seizure in Rats. . 2023; 75 - 81. 10.5505/ejm.2023.84669
Vancouver	YILDIZHAN K,GÜNEŞ H,Taskiran A Effect of Anakinra and Infliximab on Oxidative Stress and Caspase Activation in PTZ-Induced Acute Seizure in Rats. . 2023; 75 - 81. 10.5505/ejm.2023.84669
IEEE	YILDIZHAN K,GÜNEŞ H,Taskiran A "Effect of Anakinra and Infliximab on Oxidative Stress and Caspase Activation in PTZ-Induced Acute Seizure in Rats." , ss.75 - 81, 2023. 10.5505/ejm.2023.84669
ISNAD	YILDIZHAN, Kenan vd. "Effect of Anakinra and Infliximab on Oxidative Stress and Caspase Activation in PTZ-Induced Acute Seizure in Rats". (2023), 75-81. https://doi.org/10.5505/ejm.2023.84669

APA	YILDIZHAN K, GÜNEŞ H, Taskiran A (2023). Effect of Anakinra and Infliximab on Oxidative Stress and Caspase Activation in PTZ-Induced Acute Seizure in Rats. Eastern Journal of Medicine, 28(1), 75 - 81. 10.5505/ejm.2023.84669
Chicago	YILDIZHAN Kenan,GÜNEŞ Handan,Taskiran Ahmet Sevki Effect of Anakinra and Infliximab on Oxidative Stress and Caspase Activation in PTZ-Induced Acute Seizure in Rats. Eastern Journal of Medicine 28, no.1 (2023): 75 - 81. 10.5505/ejm.2023.84669
MLA	YILDIZHAN Kenan,GÜNEŞ Handan,Taskiran Ahmet Sevki Effect of Anakinra and Infliximab on Oxidative Stress and Caspase Activation in PTZ-Induced Acute Seizure in Rats. Eastern Journal of Medicine, vol.28, no.1, 2023, ss.75 - 81. 10.5505/ejm.2023.84669
AMA	YILDIZHAN K,GÜNEŞ H,Taskiran A Effect of Anakinra and Infliximab on Oxidative Stress and Caspase Activation in PTZ-Induced Acute Seizure in Rats. Eastern Journal of Medicine. 2023; 28(1): 75 - 81. 10.5505/ejm.2023.84669
Vancouver	YILDIZHAN K,GÜNEŞ H,Taskiran A Effect of Anakinra and Infliximab on Oxidative Stress and Caspase Activation in PTZ-Induced Acute Seizure in Rats. Eastern Journal of Medicine. 2023; 28(1): 75 - 81. 10.5505/ejm.2023.84669
IEEE	YILDIZHAN K,GÜNEŞ H,Taskiran A "Effect of Anakinra and Infliximab on Oxidative Stress and Caspase Activation in PTZ-Induced Acute Seizure in Rats." Eastern Journal of Medicine, 28, ss.75 - 81, 2023. 10.5505/ejm.2023.84669
ISNAD	YILDIZHAN, Kenan vd. "Effect of Anakinra and Infliximab on Oxidative Stress and Caspase Activation in PTZ-Induced Acute Seizure in Rats". Eastern Journal of Medicine 28/1 (2023), 75-81. https://doi.org/10.5505/ejm.2023.84669