Light and electron microskopic examinations in hippocampus of the rat brain following PTZ- Induced epileptic seizures

ALKAN, Faruk; Köktürk, Sibel; ŞAHİN, Deniz; İLBAY, Gül; DALÇIK, Hakkı; YARDIMOĞLU YILMAZ, MELDA; ONAR, Durmaz Funda

Light and electron microskopic examinations in hippocampus of the rat brain following PTZ- Induced epileptic seizures

MELDA YARDIMOĞLU YILMAZ, (Kocaeli Üniversitesi, Tıp Fakültesi, Histoloji Embriyoloji Anabilim Dalı, Kocaeli, Türkiye)

Gül İLBAY, (Kocaeli Üniversitesi, Tıp Fakültesi, Kocaeli, Türkiye)

SİBEL KÖKTÜRK, (İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, İstanbul, Türkiye)

Durmaz Funda ONAR, (İstanbul Üniv Tıp Fakültesi, İstanbul, Türkiye)

Deniz ŞAHİN, (Kocaeli Üniversitesi, Tıp Fakültesi, Kocaeli, Türkiye)

Faruk ALKAN, (İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, İstanbul, Türkiye)

Hakkı DALÇIK (Kocaeli Üniversitesi, Tıp Fakültesi, Histoloji Embriyoloji Anabilim Dalı, Kocaeli, Türkiye)

Journal of Applied Biological Sciences

4 1

Yıl: 2007 Cilt: 1 Sayı: 3 Sayfa Aralığı: 97 - 106 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Light and electron microskopic examinations in hippocampus of the rat brain following PTZ- Induced epileptic seizures

Öz:

The aim of this work was to evaluate hippocampal neurons in the rat brain after single and repetetive seizures induced by pentyleneterazol (PTZ) administration at light- and electron-microscopically. Acute- and chronic-PTZ groups of male Wistar albino rats were given PTZ intraperitoneal injection (i.p.), and the age-matched rats in control group were injected with normal saline. We determined contributions of apoptosis and necrosis to neuronal damage in Nissl-stained- and ultrathin-sections. Necrotic neurons were observed in PTZ-treated groups, especially in the chronic-PTZ group. Histological changes were perikaryal swelling, chromatolysis and decreasing of Nissl in the necrotic neurons. Necrotic and apoptotic neurons of the hippocampus were observed ultrastructurally in the PTZ groups. These findings demonstrated a significant decrease in the number of hippocampal neurons in the chronic-PTZ group. It is clear that in the hippocampal regions repeated PTZ-induced seizures of the rats cause neuronal damage and neuronal loss.

Anahtar Kelime: brain hippocampus seizures rats stimulants electron microscopy central nervous system epileptic seizure histology

Konular: Biyoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	YARDIMOĞLU YILMAZ M, İLBAY G, Köktürk S, ONAR D, ŞAHİN D, ALKAN F, DALÇIK H (2007). Light and electron microskopic examinations in hippocampus of the rat brain following PTZ- Induced epileptic seizures. , 97 - 106.
Chicago	YARDIMOĞLU YILMAZ MELDA,İLBAY Gül,Köktürk Sibel,ONAR Durmaz Funda,ŞAHİN Deniz,ALKAN Faruk,DALÇIK Hakkı Light and electron microskopic examinations in hippocampus of the rat brain following PTZ- Induced epileptic seizures. (2007): 97 - 106.
MLA	YARDIMOĞLU YILMAZ MELDA,İLBAY Gül,Köktürk Sibel,ONAR Durmaz Funda,ŞAHİN Deniz,ALKAN Faruk,DALÇIK Hakkı Light and electron microskopic examinations in hippocampus of the rat brain following PTZ- Induced epileptic seizures. , 2007, ss.97 - 106.
AMA	YARDIMOĞLU YILMAZ M,İLBAY G,Köktürk S,ONAR D,ŞAHİN D,ALKAN F,DALÇIK H Light and electron microskopic examinations in hippocampus of the rat brain following PTZ- Induced epileptic seizures. . 2007; 97 - 106.
Vancouver	YARDIMOĞLU YILMAZ M,İLBAY G,Köktürk S,ONAR D,ŞAHİN D,ALKAN F,DALÇIK H Light and electron microskopic examinations in hippocampus of the rat brain following PTZ- Induced epileptic seizures. . 2007; 97 - 106.
IEEE	YARDIMOĞLU YILMAZ M,İLBAY G,Köktürk S,ONAR D,ŞAHİN D,ALKAN F,DALÇIK H "Light and electron microskopic examinations in hippocampus of the rat brain following PTZ- Induced epileptic seizures." , ss.97 - 106, 2007.
ISNAD	YARDIMOĞLU YILMAZ, MELDA vd. "Light and electron microskopic examinations in hippocampus of the rat brain following PTZ- Induced epileptic seizures". (2007), 97-106.

APA	YARDIMOĞLU YILMAZ M, İLBAY G, Köktürk S, ONAR D, ŞAHİN D, ALKAN F, DALÇIK H (2007). Light and electron microskopic examinations in hippocampus of the rat brain following PTZ- Induced epileptic seizures. Journal of Applied Biological Sciences, 1(3), 97 - 106.
Chicago	YARDIMOĞLU YILMAZ MELDA,İLBAY Gül,Köktürk Sibel,ONAR Durmaz Funda,ŞAHİN Deniz,ALKAN Faruk,DALÇIK Hakkı Light and electron microskopic examinations in hippocampus of the rat brain following PTZ- Induced epileptic seizures. Journal of Applied Biological Sciences 1, no.3 (2007): 97 - 106.
MLA	YARDIMOĞLU YILMAZ MELDA,İLBAY Gül,Köktürk Sibel,ONAR Durmaz Funda,ŞAHİN Deniz,ALKAN Faruk,DALÇIK Hakkı Light and electron microskopic examinations in hippocampus of the rat brain following PTZ- Induced epileptic seizures. Journal of Applied Biological Sciences, vol.1, no.3, 2007, ss.97 - 106.
AMA	YARDIMOĞLU YILMAZ M,İLBAY G,Köktürk S,ONAR D,ŞAHİN D,ALKAN F,DALÇIK H Light and electron microskopic examinations in hippocampus of the rat brain following PTZ- Induced epileptic seizures. Journal of Applied Biological Sciences. 2007; 1(3): 97 - 106.
Vancouver	YARDIMOĞLU YILMAZ M,İLBAY G,Köktürk S,ONAR D,ŞAHİN D,ALKAN F,DALÇIK H Light and electron microskopic examinations in hippocampus of the rat brain following PTZ- Induced epileptic seizures. Journal of Applied Biological Sciences. 2007; 1(3): 97 - 106.
IEEE	YARDIMOĞLU YILMAZ M,İLBAY G,Köktürk S,ONAR D,ŞAHİN D,ALKAN F,DALÇIK H "Light and electron microskopic examinations in hippocampus of the rat brain following PTZ- Induced epileptic seizures." Journal of Applied Biological Sciences, 1, ss.97 - 106, 2007.
ISNAD	YARDIMOĞLU YILMAZ, MELDA vd. "Light and electron microskopic examinations in hippocampus of the rat brain following PTZ- Induced epileptic seizures". Journal of Applied Biological Sciences 1/3 (2007), 97-106.