Retrospective Analysis of Serology and Radiology Results in Patients with Suspected Cystic Echinococcosis Through 3 Years Period

OZMEN-CAPIN, Busra Betul; CAN, BARIŞ; karahasan, aysegul; kurşun, meltem; cimsit, canan

doi:10.4274/tpd.galenos.2023.24186

Retrospective Analysis of Serology and Radiology Results in Patients with Suspected Cystic Echinococcosis Through 3 Years Period

Büşra Betül ÖZMEN ÇAPIN, (Marmara Üniversitesi, Pendik Araştırma ve Eğitim Hastanesi, Tıbbi Mikrobiyoloji Kliniği, İstanbul, Türkiye)

Barış CAN, (Marmara Üniversitesi, Pendik Araştırma ve Eğitim Hastanesi, Tıbbi Mikrobiyoloji Kliniği, İstanbul, Türkiye)

Meltem KURŞUN, (Marmara Üniversitesi, Pendik Eğitim ve Araştırma Hastanesi, Radyoloji Bölümü, İstanbul, Türkiye)

canan cimsit, (Marmara Üniversitesi, Pendik Eğitim ve Araştırma Hastanesi, Radyoloji Bölümü, İstanbul, Türkiye)

Aysegul KARAHASAN YAGCI (Marmara Üniversitesi, Pendik Araştırma ve Eğitim Hastanesi, Tıbbi Mikrobiyoloji Kliniği, İstanbul, Türkiye)

Türkiye Parazitoloji Dergisi

5 0

Yıl: 2023 Cilt: 47 Sayı: 2 Sayfa Aralığı: 83 - 87 Metin Dili: İngilizce DOI: 10.4274/tpd.galenos.2023.24186 İndeks Tarihi: 07-06-2023

Retrospective Analysis of Serology and Radiology Results in Patients with Suspected Cystic Echinococcosis Through 3 Years Period

Öz:

Objective: Cystic echinococcosis (CE), caused by the larval stage of Echinococcus granulosus sensu latu, is one of the neglected zoonotic infectious diseases and Türkiye is among the endemic countries. This study was designed to analyze serology results for patients who were diagnosed as CE by clinical symptoms and radiological methods over a three-year period. Methods: Sera were analyzed for Anti-E. granulosus IgG by a chemiluminescence immunoassay (CLIA) (HYDATIDOSIS VIRCLIA® IgG MONOTEST, Vircell) using the VIRCLIA® (CLIA; Vircell, Granada, Spain) and results processed by the dedicated software. Cut- off for a positive test was ≥1.1 index value. Echinococcal cysts were detected based on ultrasonography, computed tomography, and magnetic resonance imaging. Results: A total of 244 sera were analyzed from 109 patients, during three-year-period from January 2018 to December 2020. Anti-E. granulosus IgG was ordered twice in 89 patients, three times in 15 patients, four times in four patients, and five times in one patient. CLIA test was positive among 41 of 109 (37.6%) patients in whom 32 (76%) had only hepatic involvement, whereas in 5 (12%) hepatic and pulmonary involvement were coexisted. The mean age of seropositive patients was 39.8 (6-75±2.72) and 61.9% of them (n=26) were female. Time intervals between sequential test orders varied from 1 day to 33 months. Eight seropositive patients turned out to be negative, and one of 66 seronegative patients became seropositive. Positive test results were converted to negative in the case of therapy or cyst inactivity. Conclusion: We may conclude that CLIA could be used as a complementary tool for CE patient follow-up.

Anahtar Kelime:

Kistik Ekinokkoz Şüphesiyle Serolojik ve Radyolojik Değerlendirme Yapılan Hastaların Üç Yıllık Periyotta Retrospektif Analizi

Öz:

Amaç: Echinococcus granulosus sensu latu’nun larval evresinin neden olduğu kistik ekinokokkoz (CE), ihmal edilen zoonotik enfeksiyon hastalıklarından biridir. Türkiye CE açısından endemik ülkeler arasında yer almaktadır. Bu çalışma, klinik semptomlar ve radyolojik yöntemlerle CE tanısı konan hastaların seroloji sonuçlarını üç yıllık bir süre içinde analiz etmek için tasarlanmıştır. Yöntemler: Serum örnekleri VIRCLIA® (CLIA; Vircell, Granada, İspanya) kullanılarak bir kemilüminesans immünoanaliz (CLIA) (HYDATIDOSIS VIRCLIA® IgG MONOTEST, Vircell) yöntemi ile anti-E. granulosus IgG için analiz edildi ve sonuçlar özel bir yazılım programı kullanılarak değerlendirildi. Pozitif sonuç için indeks değeri ≥1,1 olarak belirlendi. Ekinokok kistlerinin tespitinde ultrasonografi, bilgisayarlı tomografi ve manyetik rezonans görüntüleme kullanıldı. Bulgular: Ocak 2018-Aralık 2020 tarihleri arasında 109 hastadan toplam 244 serum analiz edildi. Anti-E. granulosus IgG 89 hastada iki kez, 15 hastada üç kez, dört hastada dört kez ve bir hastada beş kez istendi. CLIA testi hastaların 41’inde (37,6) pozitif bulundu ve bu hastaların 32’sinde (%76) sadece karaciğer turulumu var iken, 5’inde (%12) akciğer ve karaciğer tutulumu birlikte saptandı. Seropozitif hastların yaş ortalaması 39,8 (6-75±2,72) olup, %61,4’ü kadındı. Ardışık test istemleri arasındaki zaman aralıkları 1 gün ile 33 ay arasında değişiyordu. İzlem sürecinde 8 seropozitif hasta negatife dönerken 66 seronegatif hastadan biri seropozitif oldu. Pozitif serolojinin tedavi veya kist inaktivasyonu durumunda negatife dönüştüğü belirlendi. Sonuç: CLIA’nın CE hasta takibi için tamamlayıcı bir tanı yöntemi olarak kullanılabileceği sonucuna varabiliriz.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	OZMEN-CAPIN B, CAN B, kurşun m, cimsit c, karahasan a (2023). Retrospective Analysis of Serology and Radiology Results in Patients with Suspected Cystic Echinococcosis Through 3 Years Period. , 83 - 87. 10.4274/tpd.galenos.2023.24186
Chicago	OZMEN-CAPIN Busra Betul,CAN BARIŞ,kurşun meltem,cimsit canan,karahasan aysegul Retrospective Analysis of Serology and Radiology Results in Patients with Suspected Cystic Echinococcosis Through 3 Years Period. (2023): 83 - 87. 10.4274/tpd.galenos.2023.24186
MLA	OZMEN-CAPIN Busra Betul,CAN BARIŞ,kurşun meltem,cimsit canan,karahasan aysegul Retrospective Analysis of Serology and Radiology Results in Patients with Suspected Cystic Echinococcosis Through 3 Years Period. , 2023, ss.83 - 87. 10.4274/tpd.galenos.2023.24186
AMA	OZMEN-CAPIN B,CAN B,kurşun m,cimsit c,karahasan a Retrospective Analysis of Serology and Radiology Results in Patients with Suspected Cystic Echinococcosis Through 3 Years Period. . 2023; 83 - 87. 10.4274/tpd.galenos.2023.24186
Vancouver	OZMEN-CAPIN B,CAN B,kurşun m,cimsit c,karahasan a Retrospective Analysis of Serology and Radiology Results in Patients with Suspected Cystic Echinococcosis Through 3 Years Period. . 2023; 83 - 87. 10.4274/tpd.galenos.2023.24186
IEEE	OZMEN-CAPIN B,CAN B,kurşun m,cimsit c,karahasan a "Retrospective Analysis of Serology and Radiology Results in Patients with Suspected Cystic Echinococcosis Through 3 Years Period." , ss.83 - 87, 2023. 10.4274/tpd.galenos.2023.24186
ISNAD	OZMEN-CAPIN, Busra Betul vd. "Retrospective Analysis of Serology and Radiology Results in Patients with Suspected Cystic Echinococcosis Through 3 Years Period". (2023), 83-87. https://doi.org/10.4274/tpd.galenos.2023.24186

APA	OZMEN-CAPIN B, CAN B, kurşun m, cimsit c, karahasan a (2023). Retrospective Analysis of Serology and Radiology Results in Patients with Suspected Cystic Echinococcosis Through 3 Years Period. Türkiye Parazitoloji Dergisi, 47(2), 83 - 87. 10.4274/tpd.galenos.2023.24186
Chicago	OZMEN-CAPIN Busra Betul,CAN BARIŞ,kurşun meltem,cimsit canan,karahasan aysegul Retrospective Analysis of Serology and Radiology Results in Patients with Suspected Cystic Echinococcosis Through 3 Years Period. Türkiye Parazitoloji Dergisi 47, no.2 (2023): 83 - 87. 10.4274/tpd.galenos.2023.24186
MLA	OZMEN-CAPIN Busra Betul,CAN BARIŞ,kurşun meltem,cimsit canan,karahasan aysegul Retrospective Analysis of Serology and Radiology Results in Patients with Suspected Cystic Echinococcosis Through 3 Years Period. Türkiye Parazitoloji Dergisi, vol.47, no.2, 2023, ss.83 - 87. 10.4274/tpd.galenos.2023.24186
AMA	OZMEN-CAPIN B,CAN B,kurşun m,cimsit c,karahasan a Retrospective Analysis of Serology and Radiology Results in Patients with Suspected Cystic Echinococcosis Through 3 Years Period. Türkiye Parazitoloji Dergisi. 2023; 47(2): 83 - 87. 10.4274/tpd.galenos.2023.24186
Vancouver	OZMEN-CAPIN B,CAN B,kurşun m,cimsit c,karahasan a Retrospective Analysis of Serology and Radiology Results in Patients with Suspected Cystic Echinococcosis Through 3 Years Period. Türkiye Parazitoloji Dergisi. 2023; 47(2): 83 - 87. 10.4274/tpd.galenos.2023.24186
IEEE	OZMEN-CAPIN B,CAN B,kurşun m,cimsit c,karahasan a "Retrospective Analysis of Serology and Radiology Results in Patients with Suspected Cystic Echinococcosis Through 3 Years Period." Türkiye Parazitoloji Dergisi, 47, ss.83 - 87, 2023. 10.4274/tpd.galenos.2023.24186
ISNAD	OZMEN-CAPIN, Busra Betul vd. "Retrospective Analysis of Serology and Radiology Results in Patients with Suspected Cystic Echinococcosis Through 3 Years Period". Türkiye Parazitoloji Dergisi 47/2 (2023), 83-87. https://doi.org/10.4274/tpd.galenos.2023.24186