AIM: To determine whether the social support perceived by healthcare professionals involved in the pandemic process is related to depression, anxiety, and stress levels and, if so, to what extent it is related to which factors. MATERIALS AND METHODS: 197 people consisting of doctors and nurses / health officers who were assigned in the units related to the pandemic in S.B.Ankara Training and Research Hospital were included in the study. Sociodemographic data form, DASS-42 and ÇBASDÖ were applied to the sample group. RESULTS: 197 participants in total; 58.4% doctor, 41.6% nurse / health officer, 65% female, 50% married and 40.4% in the COVID-19 service, 24.1% in the emergency department 22.3% of them were working in the COVID-19 intensive care unit and 11.2% in the COVID-19 outpatient clinic. The proportion of healthcare workers with moderate and severe depressive symptoms were 53.3%, those with anxiety symptoms 53.8%, and those with stress symptoms 48.7%. It was found that nurses had statistically significantly higher depression (p = 0.041), anxiety (p = 0.013), and stress scores from doctors (p = 0.009) and women had statistically higher than men in all subscales of DASS-42. As the weekly working hours increased, depression increased (p = 0.012), and also anxiety levels were found higher in those who worked more than 24 hours per week (p <0.05). It was observed that the ÇBASDÖ-family subscale was moderately strong, negatively correlated with the DASS-42 depression subscale (p = 0.001, r = -0.439), and the DASS-42 total score was negatively correlated with the ÇBASDÖ total score (p <0.001, r=-0.350) CONCLUSION: The decrease in perceived social support can manifest itself with an increase in the anxiety, depression and stress levels of the health care professionals involved in the pandemic.