In the literature, there is a positive correlation between sexual and marital satisfactions. When the current literature is examined, there is no study examining the marriage satisfaction in patients with Multiple Sclerosis (PwMS). This study was conducted with 100 married PwMS. The majority of participants (n=71) are females. Demographic Information Form, Marital Life Scale (MLS), Life Satisfaction Scale (LSS), and Arizona Sexual Experiences Scale (ASEX) were used to collect data. Compared to other demographic variables, the median score of the marital life scale differs according to the type of marriage with the spouse (p = 0.008). The difference arises from the fact that the median score of the group getting married by introducing friends is low compared to the ones who get married by means of meeting and agreement. Marital life scale score did not differ according to other demographic characteristics (p> 0.05). Life satisfaction scale scores did not differ according to demographic characteristics (p> 0.05). The mean score of the ASEX differed by gender (p = 0.015). The mean value was found to be 13.8 for women and 17 for men. The mean score of the Arizona Sexual Experiences Scale differs according to age (p = 0.019). The mean score in the 25-34 age range was 14.2, in the 35-44 age range 16.2, in the 45-54 age range 16.1 and in the 55-64 age range 22.3. There was a significant positive relationship between marital life scale and life satisfaction (p <0.001). A significant negative correlation was found between marital satisfaction and sexual experiences (p <0.009). A negative correlation was found between life satisfaction and sexual experiences scale (p <0.001). Sexual dysfunction affects marriage and life satisfactions negatively in PwMS and they need to have new therapeutic approaches.