Objective: The incidence of Moebius syndrome (MS), in which craniofacial anomalies are common, is not fully known and is thought to result from a combination of environmental&genetic factors. Most of the signs and symptoms of MS, are due to the absence or underdevelopment of the 6th and 7th cranial nerves. Craniofacial anomalies are also among the prominent symptoms of MS. Micrognathia, short or unusually shaped tongue and microstomia may seen in MS. Dental treatments of children with MS may need to be done under general anesthesia. However, there are some situations that need to be considered during general anesthesia. The quality of life of individuals affected by this syndrome is negatively affected and they usually need special care. Case: This case report addresses the clinical and dental features of a child with MS and the clinical situations and difficulties encountered during dental treatment. Conclusion: Considering the variable oral symptoms of patients with Moebius syndrome, it is clear that the clinical follow-up of these patients requires a multidisciplinary approach involving dental professionals.