T1 relaxation time is prolonged in healthy aging: a whole brain study

AKTAŞ DİNÇER, HAYRIYE; Ağıldere, Ahmet Muhteşem; Gokcay, Didem

doi:10.55730/1300-0144.5630

T1 relaxation time is prolonged in healthy aging: a whole brain study

HAYRIYE AKTAŞ DİNÇER, (Orta Doğu Teknik Üniversitesi, Fen Bilimleri Enstitüsü, Biyomedikal Mühendisliği Anabilim Dalı, Ankara, Türkiye)

Ahmet Muhteşem AĞILDERE, (Başkent Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı Ankara, Türkiye)

Didem Gokcay (Orta Doğu Teknik Üniversitesi, Enformatik Enstitüsü, Sağlık Bilişimi Anabilim Dalı, Ankara, Türkiye)

Turkish Journal of Medical Sciences

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Yıl: 2023 Cilt: 53 Sayı: 3 Sayfa Aralığı: 675 - 684 Metin Dili: İngilizce DOI: 10.55730/1300-0144.5630 İndeks Tarihi: 01-08-2023

T1 relaxation time is prolonged in healthy aging: a whole brain study

Öz:

Background/aim: Measurement of tissue characteristics such as the longitudinal relaxation time (T1) provides complementary information to the volumetric and surface based structural analyses. We aimed to investigate T1 relaxation time characteristics in healthy aging via an exploratory design in the whole brain. The data processing pipeline was designed to minimize errors related to aging effects such as atrophy. Materials and methods: Sixty healthy participants underwent MRI scanning (28 F, 32 M, age range: 18–78, 30 young and 30 old) in November 2017–March 2018 at the Bilkent University UMRAM Center. Four images with varying flip angles with FLASH (fast low angle shot magnetic resonance imaging) sequence and a high-resolution structural image with MP-RAGE (Magnetization Prepared - RApid Gradient Echo) were acquired. $T_1$relaxation times of the entire brain were mapped by using the region of interest (ROI) based method on 134 brain areas in young and old populations. Results: $T_1$ prolongation was observed in various subcortical (bilateral hippocampus, caudate and thalamus) and cortical brain structures (bilateral precentral gyrus, bilateral middle frontal gyrus, bilateral supplementary motor area (SMA), left middle occipital gyrus, bilateral postcentral gyrus and bilateral Heschl’s gyrus) as well as cerebellar regions (GM regions of cerebellum: bilateral cerebellum III, cerebellum IV V, cerebellum X, cerebellar vermis u 4 5, cerebellar vermis u 9 and WM cerebellar regions: left cerebellum IX, bilateral cerebellum X and cerebellar vermis u 4 5). Conclusion: $T_1$ mapping provides a practical quantitative MRI (qMRI) methodology for studying the tissue characteristics in healthy aging. $T_1$ values are significantly increased in the aging group among half of the studied ROIs (57 ROIs out of 134).

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APA	AKTAŞ DİNÇER H, Ağıldere A, Gokcay D (2023). T1 relaxation time is prolonged in healthy aging: a whole brain study. , 675 - 684. 10.55730/1300-0144.5630
Chicago	AKTAŞ DİNÇER HAYRIYE,Ağıldere Ahmet Muhteşem,Gokcay Didem T1 relaxation time is prolonged in healthy aging: a whole brain study. (2023): 675 - 684. 10.55730/1300-0144.5630
MLA	AKTAŞ DİNÇER HAYRIYE,Ağıldere Ahmet Muhteşem,Gokcay Didem T1 relaxation time is prolonged in healthy aging: a whole brain study. , 2023, ss.675 - 684. 10.55730/1300-0144.5630
AMA	AKTAŞ DİNÇER H,Ağıldere A,Gokcay D T1 relaxation time is prolonged in healthy aging: a whole brain study. . 2023; 675 - 684. 10.55730/1300-0144.5630
Vancouver	AKTAŞ DİNÇER H,Ağıldere A,Gokcay D T1 relaxation time is prolonged in healthy aging: a whole brain study. . 2023; 675 - 684. 10.55730/1300-0144.5630
IEEE	AKTAŞ DİNÇER H,Ağıldere A,Gokcay D "T1 relaxation time is prolonged in healthy aging: a whole brain study." , ss.675 - 684, 2023. 10.55730/1300-0144.5630
ISNAD	AKTAŞ DİNÇER, HAYRIYE vd. "T1 relaxation time is prolonged in healthy aging: a whole brain study". (2023), 675-684. https://doi.org/10.55730/1300-0144.5630

APA	AKTAŞ DİNÇER H, Ağıldere A, Gokcay D (2023). T1 relaxation time is prolonged in healthy aging: a whole brain study. Turkish Journal of Medical Sciences, 53(3), 675 - 684. 10.55730/1300-0144.5630
Chicago	AKTAŞ DİNÇER HAYRIYE,Ağıldere Ahmet Muhteşem,Gokcay Didem T1 relaxation time is prolonged in healthy aging: a whole brain study. Turkish Journal of Medical Sciences 53, no.3 (2023): 675 - 684. 10.55730/1300-0144.5630
MLA	AKTAŞ DİNÇER HAYRIYE,Ağıldere Ahmet Muhteşem,Gokcay Didem T1 relaxation time is prolonged in healthy aging: a whole brain study. Turkish Journal of Medical Sciences, vol.53, no.3, 2023, ss.675 - 684. 10.55730/1300-0144.5630
AMA	AKTAŞ DİNÇER H,Ağıldere A,Gokcay D T1 relaxation time is prolonged in healthy aging: a whole brain study. Turkish Journal of Medical Sciences. 2023; 53(3): 675 - 684. 10.55730/1300-0144.5630
Vancouver	AKTAŞ DİNÇER H,Ağıldere A,Gokcay D T1 relaxation time is prolonged in healthy aging: a whole brain study. Turkish Journal of Medical Sciences. 2023; 53(3): 675 - 684. 10.55730/1300-0144.5630
IEEE	AKTAŞ DİNÇER H,Ağıldere A,Gokcay D "T1 relaxation time is prolonged in healthy aging: a whole brain study." Turkish Journal of Medical Sciences, 53, ss.675 - 684, 2023. 10.55730/1300-0144.5630
ISNAD	AKTAŞ DİNÇER, HAYRIYE vd. "T1 relaxation time is prolonged in healthy aging: a whole brain study". Turkish Journal of Medical Sciences 53/3 (2023), 675-684. https://doi.org/10.55730/1300-0144.5630