Aim: In this study, it was aimed to investigate the effects of auditory stimuli and exercise on structural measurements, functional characteristics and sex hormones of rats fed with genetically modified organisms (GMO).Materials and Methods: A total of 64 8-week-old Spraque Dawley rats, 32 male and 32 female, were used in the study. GMO feeding, auditory stimulus and exercise were applied to both male and female rats. Control groups were also formed at the same time as the experimental groups. GMO application; It was fed by mixing 20ml water+20ml corn syrup per day. Auditory application; Segah and Hüseyni maqams were played at 55 decibels loudness for 60 minutes a day. Exercise app; It was applied as challenging swimming in an 80 cm long and 40 cm wide pool.Results: It was determined that the body weights of all rats treated with GMO showed a significant increase (p<0.05). Significant increases in blood lactate levels were observed in exercise-treated rats (p<0.05). It was determined that musical auditory stimuli were effective on sex hormones and significant decreases occurred in estrogen levels of female rats fed GMOs (p<0.05). Conclusion: It was observed that the preference of feeding with GMO significantly affected the body composition of the subjects. It was determined that swimming and sound stimuli were effective on sex hormones. It was determined that there was an increase in testosterone levels in male rats fed with exercise and GMO. A significant decrease was determined in the estrogen levels of female rats, especially in those fed with GMOs. For this reason, it was seen that the changes in the sex hormones caused by the high fructose-containing GMO diet can cause very important health problems. It was determined that more research on the subject should be done in order to explain the system response mechanisms of the organism, the relationship between exercise and auditory stimuli and GMO nutrition.