Antimicrobial, antifibrinolytic, enzyme inhibitory and wound healing properties of zinc borate

Ayrıkçil, Semih; Ugur, Aysel; Sarac, Nurdan; Boran, Rukiye; BAYGAR, TUBA; Yılmaz, Derviş

doi:10.30728/boron.1180847

Antimicrobial, antifibrinolytic, enzyme inhibitory and wound healing properties of zinc borate

Rukiye BORAN GULEN, (Aksaray Üniversitesi, Tıbbi Hizmetler ve Teknikler Bölümü, Tıbbi Laboratuvar Programı, Sağlık Hizmetleri Meslek Yüksekokulu, Aksaray, 68100, Türkiye)

Tuba BAYGAR, (Muğla Sıtkı Koçman Üniversitesi, Malzeme Araştırma Laboratuvarı, Araştırma Laboratuvarları Merkezi, Muğla, 48000, Türkiye)

Nurdan SARAÇ, (Muğla Sıtkı Koçman Üniversitesi, Biyoloji Bölümü, Fen Fakültesi, Muğla, 48000, Türkiye)

Semih AYRIKÇİL, (Nuh Naci Yazgan Üniversitesi, Diş Hekimliği Fakültesi, Ağız, Diş ve Çene Cerrahisi Anabilim Dalı, Kayseri, 38040, Türkiye)

Derviş YILMAZ, (Gazi Üniversitesi, Diş Hekimliği Fakültesi, Ağız, Diş ve Çene Cerrahisi Anabilim Dalı, Ankara, 06500, Türkiye)

Aysel UĞUR (Gazi Üniversitesi, Diş Hekimliği Fakültesi, Temel Bilimler Bölümü, Tıbbi Mikrobiyoloji Anabilim Dalı, Ankara, 06500, Türkiye)

BOR DERGİSİ

2 0

Yıl: 2023 Cilt: 8 Sayı: 3 Sayfa Aralığı: 99 - 104 Metin Dili: İngilizce DOI: 10.30728/boron.1180847 İndeks Tarihi: 06-10-2023

Antimicrobial, antifibrinolytic, enzyme inhibitory and wound healing properties of zinc borate

Öz:

Boron containing compounds (BCGs) have recently been used for pharmaceutical applications. Zinc, an essential element, is known to be one of the most promising biodegradable metals. The present study was conducted to determine the wound healing properties of zinc borate with its antimicrobial, antifibrinolytic and enzyme inhibitory characteristics. In vitro scratch wound healing assay revealed that zinc borate at 0.01 µg/mL concentration stimulated the proliferation of 3T3 fibroblast cells after 24 h of scar formation. The highest enzyme inhibition was observed against collagenase at 1 mg/mL (81.5%). Minimum inhibition concentration (MIC) values were determined as 1 mg/mL and 0.5 mg/mL against Candida albicans and Staphylococcus aureus, respectively. Zinc borate did not have any fibrinolytic activity at 1, 0.5 and 0.1 mg/mL concentrations. It can be suggested that zinc borate can be used effectively to improve the wound healing process and to prevent the possible wound infections.

Anahtar Kelime: zinc borate wound healing enzyme inhibition antimicrobial antifibrinolytic

Çinko borat’ın antimikrobiyal, antifibrinolitik, enzim inhibisyonu ve yara iyileşme özellikleri

Öz:

Boron içerikli bileşenler son zamanlarda farmasötik uygulamalarda kullanılmaktadır. Esansiyel bir element olan Çinko (Zn) umut veren biyobozunur metallerden biridir. Bu çalışma, çinko borat’ın antimikrobiyal, antifibrinolitik, yara iyileşme ve enzim inhibisyonu karakteristiklerini belirlemek üzere tasarlanmıştır. In vitro yara çizik testine göre yara oluşumun 24. saatinde çinko boratın 0.01 µg/mL konsantrasyonda 3T3 fibroblast hücrelerinin proliferasyonunu uyardığı belirlenmiştir. En yüksek enzim inhibisyonu kollagenaza karşı 1 mg/mL konsantrasyonda gözlenmiştir. Candida albicans ve Staphylococcus aureus’a karşı çinko boratın minimum inhibisyon konsantrasyonları (MIC) sırasıyla 1 mg/mL ve 0.5 mg/mL olarak tespit edilmiştir. Çinko boratın 1, 0.5 ve 0.1 mg/mL konsantrasyonlarda herhangi bir fibrinolitik aktivitesi gözlenmemiştir. Çinko boratın yara iyileşme sürecini iyileştirmede etkin bir şekilde kullanılabileceği ve muhtemel yara enfeksiyonlarını önleyebileceği sonucuna varılmıştır.

Anahtar Kelime: zinc borate wound healing enzyme inhibition antimicrobial antifibrinolytic

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Boran R, BAYGAR T, Sarac N, Ayrıkçil S, Yılmaz D, Ugur A (2023). Antimicrobial, antifibrinolytic, enzyme inhibitory and wound healing properties of zinc borate. , 99 - 104. 10.30728/boron.1180847
Chicago	Boran Rukiye,BAYGAR TUBA,Sarac Nurdan,Ayrıkçil Semih,Yılmaz Derviş,Ugur Aysel Antimicrobial, antifibrinolytic, enzyme inhibitory and wound healing properties of zinc borate. (2023): 99 - 104. 10.30728/boron.1180847
MLA	Boran Rukiye,BAYGAR TUBA,Sarac Nurdan,Ayrıkçil Semih,Yılmaz Derviş,Ugur Aysel Antimicrobial, antifibrinolytic, enzyme inhibitory and wound healing properties of zinc borate. , 2023, ss.99 - 104. 10.30728/boron.1180847
AMA	Boran R,BAYGAR T,Sarac N,Ayrıkçil S,Yılmaz D,Ugur A Antimicrobial, antifibrinolytic, enzyme inhibitory and wound healing properties of zinc borate. . 2023; 99 - 104. 10.30728/boron.1180847
Vancouver	Boran R,BAYGAR T,Sarac N,Ayrıkçil S,Yılmaz D,Ugur A Antimicrobial, antifibrinolytic, enzyme inhibitory and wound healing properties of zinc borate. . 2023; 99 - 104. 10.30728/boron.1180847
IEEE	Boran R,BAYGAR T,Sarac N,Ayrıkçil S,Yılmaz D,Ugur A "Antimicrobial, antifibrinolytic, enzyme inhibitory and wound healing properties of zinc borate." , ss.99 - 104, 2023. 10.30728/boron.1180847
ISNAD	Boran, Rukiye vd. "Antimicrobial, antifibrinolytic, enzyme inhibitory and wound healing properties of zinc borate". (2023), 99-104. https://doi.org/10.30728/boron.1180847

APA	Boran R, BAYGAR T, Sarac N, Ayrıkçil S, Yılmaz D, Ugur A (2023). Antimicrobial, antifibrinolytic, enzyme inhibitory and wound healing properties of zinc borate. BOR DERGİSİ, 8(3), 99 - 104. 10.30728/boron.1180847
Chicago	Boran Rukiye,BAYGAR TUBA,Sarac Nurdan,Ayrıkçil Semih,Yılmaz Derviş,Ugur Aysel Antimicrobial, antifibrinolytic, enzyme inhibitory and wound healing properties of zinc borate. BOR DERGİSİ 8, no.3 (2023): 99 - 104. 10.30728/boron.1180847
MLA	Boran Rukiye,BAYGAR TUBA,Sarac Nurdan,Ayrıkçil Semih,Yılmaz Derviş,Ugur Aysel Antimicrobial, antifibrinolytic, enzyme inhibitory and wound healing properties of zinc borate. BOR DERGİSİ, vol.8, no.3, 2023, ss.99 - 104. 10.30728/boron.1180847
AMA	Boran R,BAYGAR T,Sarac N,Ayrıkçil S,Yılmaz D,Ugur A Antimicrobial, antifibrinolytic, enzyme inhibitory and wound healing properties of zinc borate. BOR DERGİSİ. 2023; 8(3): 99 - 104. 10.30728/boron.1180847
Vancouver	Boran R,BAYGAR T,Sarac N,Ayrıkçil S,Yılmaz D,Ugur A Antimicrobial, antifibrinolytic, enzyme inhibitory and wound healing properties of zinc borate. BOR DERGİSİ. 2023; 8(3): 99 - 104. 10.30728/boron.1180847
IEEE	Boran R,BAYGAR T,Sarac N,Ayrıkçil S,Yılmaz D,Ugur A "Antimicrobial, antifibrinolytic, enzyme inhibitory and wound healing properties of zinc borate." BOR DERGİSİ, 8, ss.99 - 104, 2023. 10.30728/boron.1180847
ISNAD	Boran, Rukiye vd. "Antimicrobial, antifibrinolytic, enzyme inhibitory and wound healing properties of zinc borate". BOR DERGİSİ 8/3 (2023), 99-104. https://doi.org/10.30728/boron.1180847