The effect of natural surfactants on the development of postoperative intraabdominal adhesion

güler, ahmet gökhan; Karakaya, Ali Erdal; Doğan, Ahmet Burak; Bahar, Abdulkadir Yasir; YURTTUTAN, SADIK

doi:10.55730/1300-0144.5676

The effect of natural surfactants on the development of postoperative intraabdominal adhesion

Ahmet Gökhan GÜLER, (Sütçü İmam Üniversitesi, Tıp Fakültesi, Çocuk Cerrahisi Anabilim Dalı, Kahramanmaraş, Türkiye)

Ali Erdal KARAKAYA, (Sütçü İmam Üniversitesi, Tıp Fakültesi, Çocuk Cerrahisi Anabilim Dalı, Kahramanmaraş, Türkiye)

Ahmet Burak DOĞAN, (Erciyes Üniversitesi, Tıp Fakültesi, Çocuk Cerrahisi Anabilim Dalı, Kayseri, Türkiye)

Abdülkadir Yasir BAHAR, (Sütçü İmam Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Kahramanmaraş)

Sadık YURTTUTAN (Sütçü İmam Üniversitesi, Tıp Fakültesi, Neonatoloji Anabilim Dalı, Kahramanmaraş, Türkiye)

Turkish Journal of Medical Sciences

2 0

Yıl: 2023 Cilt: 53 Sayı: 5 Sayfa Aralığı: 1112 - 1119 Metin Dili: İngilizce DOI: 10.55730/1300-0144.5676 İndeks Tarihi: 24-11-2023

The effect of natural surfactants on the development of postoperative intraabdominal adhesion

Öz:

Background/aim: The development of postoperative adhesion after abdominal surgery is sometimes a severe problem. Our study investigates the effectiveness of exogenous surfactant application in preventing adhesion development in the experimental adhesion model. Materials and methods: This randomized-controlled interventional study was carried out in the animal laboratory of Kahramanmaraş Sütçü İmam University between March 1 and March 31, 2020. An experimental intra-abdominal adhesion model was established in 24 adult female rats by cecal abrasion. Rats were randomly divided into four groups. Groups I, II, and III were taken intraperitoneally as beractant, poractant, and calfactant applied groups, respectively. Group IV was the control group. Relaparotomy was performed in all groups on the 15th postoperative day, and intra-abdominal adhesions were scored macroscopically according to the Canbaz scoring system. In addition, the cecal regions were evaluated microscopically and scored according to the Zühlke microscopic classification system. The scores of the groups were compared statistically. Results: The Zühlke adhesion development score was significantly lower in the exogenous surfactant applied groups. In addition, when the surfactant-applied groups were compared among themselves, it was seen that the adhesion score in the beractant group was significantly better than the other surfactant types (p < 0.01). Conclusion: Our study results showed that prophylactic intraperitoneal surfactant application significantly reduced postoperative adhesion development, particularly beractant.

Anahtar Kelime: Postoperative adhesion surface-active phospholipids pulmonary surfactant beractant poractant calfactant

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	güler a, Karakaya A, Doğan A, Bahar A, YURTTUTAN S (2023). The effect of natural surfactants on the development of postoperative intraabdominal adhesion. , 1112 - 1119. 10.55730/1300-0144.5676
Chicago	güler ahmet gökhan,Karakaya Ali Erdal,Doğan Ahmet Burak,Bahar Abdulkadir Yasir,YURTTUTAN SADIK The effect of natural surfactants on the development of postoperative intraabdominal adhesion. (2023): 1112 - 1119. 10.55730/1300-0144.5676
MLA	güler ahmet gökhan,Karakaya Ali Erdal,Doğan Ahmet Burak,Bahar Abdulkadir Yasir,YURTTUTAN SADIK The effect of natural surfactants on the development of postoperative intraabdominal adhesion. , 2023, ss.1112 - 1119. 10.55730/1300-0144.5676
AMA	güler a,Karakaya A,Doğan A,Bahar A,YURTTUTAN S The effect of natural surfactants on the development of postoperative intraabdominal adhesion. . 2023; 1112 - 1119. 10.55730/1300-0144.5676
Vancouver	güler a,Karakaya A,Doğan A,Bahar A,YURTTUTAN S The effect of natural surfactants on the development of postoperative intraabdominal adhesion. . 2023; 1112 - 1119. 10.55730/1300-0144.5676
IEEE	güler a,Karakaya A,Doğan A,Bahar A,YURTTUTAN S "The effect of natural surfactants on the development of postoperative intraabdominal adhesion." , ss.1112 - 1119, 2023. 10.55730/1300-0144.5676
ISNAD	güler, ahmet gökhan vd. "The effect of natural surfactants on the development of postoperative intraabdominal adhesion". (2023), 1112-1119. https://doi.org/10.55730/1300-0144.5676

APA	güler a, Karakaya A, Doğan A, Bahar A, YURTTUTAN S (2023). The effect of natural surfactants on the development of postoperative intraabdominal adhesion. Turkish Journal of Medical Sciences, 53(5), 1112 - 1119. 10.55730/1300-0144.5676
Chicago	güler ahmet gökhan,Karakaya Ali Erdal,Doğan Ahmet Burak,Bahar Abdulkadir Yasir,YURTTUTAN SADIK The effect of natural surfactants on the development of postoperative intraabdominal adhesion. Turkish Journal of Medical Sciences 53, no.5 (2023): 1112 - 1119. 10.55730/1300-0144.5676
MLA	güler ahmet gökhan,Karakaya Ali Erdal,Doğan Ahmet Burak,Bahar Abdulkadir Yasir,YURTTUTAN SADIK The effect of natural surfactants on the development of postoperative intraabdominal adhesion. Turkish Journal of Medical Sciences, vol.53, no.5, 2023, ss.1112 - 1119. 10.55730/1300-0144.5676
AMA	güler a,Karakaya A,Doğan A,Bahar A,YURTTUTAN S The effect of natural surfactants on the development of postoperative intraabdominal adhesion. Turkish Journal of Medical Sciences. 2023; 53(5): 1112 - 1119. 10.55730/1300-0144.5676
Vancouver	güler a,Karakaya A,Doğan A,Bahar A,YURTTUTAN S The effect of natural surfactants on the development of postoperative intraabdominal adhesion. Turkish Journal of Medical Sciences. 2023; 53(5): 1112 - 1119. 10.55730/1300-0144.5676
IEEE	güler a,Karakaya A,Doğan A,Bahar A,YURTTUTAN S "The effect of natural surfactants on the development of postoperative intraabdominal adhesion." Turkish Journal of Medical Sciences, 53, ss.1112 - 1119, 2023. 10.55730/1300-0144.5676
ISNAD	güler, ahmet gökhan vd. "The effect of natural surfactants on the development of postoperative intraabdominal adhesion". Turkish Journal of Medical Sciences 53/5 (2023), 1112-1119. https://doi.org/10.55730/1300-0144.5676