This study aims to investigate the effect of using an interactive e-book in teaching the “Energy Conversions and Environmental Science” unit of the science course on the academic achievement, attitudes, and motivations of 8th-grade students. The study used a quasi-experimental design with a pretest-posttest control group. The participants of the research, which was carried out in the 2020-2021 academic year, consisted of 60 secondary school students studying in two secondary schools in the Muradiye district of Van. There were 32 students in the experimental and 28 in the control group. The unit, which lasted six weeks (24 lesson hours), was taught using an interactive e-book for the experimental group, while a science textbook was used for the control group. The “Energy Conversions and Environmental Science Achievement Test”, “Science Attitude Scale”, and “Motivation Scale toward Science Learning” were the three different data collection tools used in the study. The data were analyzed using an unpaired t-test, and it was found that while there was no difference in attitude or motivation between the experimental and control groups, there was a statistically significant difference in academic achievement. These findings are thought to be the result of the students’ anxiety because of the pandemic and the fact that the research was only conducted for one unit.