Yıl: 2010 Cilt: 27 Sayı: 2 Sayfa Aralığı: 121 - 126 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Amphiphysin autoimmunity: Associated neurological syndromes and tumors in the Turkish population

Öz:
Amaç: Bu çalışmada Türk toplumundaki amfifizin otoimmünitesinin klinik eşlikçilerinin belirlenmesi amaçlandı.Olgular ve Yöntem: Subakut nörolojik bulgular ile başvuran ve serum örneklerinin immün reaksiyon paterni amfifizin antikoru varlığını düşündüren 6 olgunun örnekleri seçildi. Amfifizin antikor pozitifliği rekombinan amfifizin proteini içeren immünoblotlarla doğrulandı.Sonuçlar: İki olguda limbik ensefalit, 1 olguda miyelopati ve 3 olguda nöropati vardı. Birer olguda meme, akciğer ve endometrium kanserleri saptandı. İki olguda metastaz (bir olguda mesane kanseri ve bir olguda bilinmeyen bir tümör) saptanırken bir olguda tümör belirlenemedi. Olguların çoğu veya tamamı normal görüntüleme ve beyin-omurilik sıvısı (BOS) bulguları ve immünsüpresif tedaviye kötü cevap gösterdi. Olguların hiçbirinin serumunda diğer hücre içi antijenlere karşı antikorlar yoktu.Tartışma: Olgularımız daha önce bildirilenlerden, anormal BOS bulgularının azlığı, eşlik eden diğer paraneoplastik antikorların yokluğu ve daha önce amfifizin otoimmünitesi ile ilişkili olarak bildirilmemiş tümör tiplerinin varlığı ile ayrılmaktadır.
Anahtar Kelime:

Konular: Nörolojik Bilimler

Türk toplumunda amfifizin otoimmünitesine eşlik eden klinik sendromlar ve tümörler

Öz:
Objective: Our aim was to determine the clinical accompaniments of the amphiphysin autoimmunity in the Turkish population.Patients and Methods: Sera of 6 patients with a subacute neurological presentation were selected because of their immunoreactivity pattern suggestive of amphiphysin-antibodies. Amphiphysin-antibody positivity was confirmed by immunoblots containing recombinant amphiphysin protein.Results: Two patients had limbic encephalitis, 1 myelopathy and 3 neuropathy. Breast, lung and endometrium cancers were detected in one patient each. Two patients had metastasis (of a bladder cancer and an unknown tumor) and no tumors could be found in one patient. Most or all patients exhibited normal imaging and cerebrospinal fluid (CSF) findings and poor response to immunosuppression. None of the patients' sera contained antibodies to other intracellular paraneoplastic antigens.Conclusions: Our cohort differs from the previously reported ones by reduced frequency of abnormal CSF findings, absence of other coexisting paraneoplastic antibodies and presence of tumor types that have not been previously associated with amphiphysin autoimmunity.
Anahtar Kelime:

Konular: Nörolojik Bilimler
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Tuzun E, BEBEK N, içöz s, DURMUŞ TEKÇE H, KÜRTÜNCÜ M, Gurses C, AKMAN-DEMİR G (2010). Amphiphysin autoimmunity: Associated neurological syndromes and tumors in the Turkish population. , 121 - 126.
Chicago Tuzun Erdem,BEBEK Nerses,içöz sema,DURMUŞ TEKÇE Hacer,KÜRTÜNCÜ Murat,Gurses Candan,AKMAN-DEMİR Gülşen Amphiphysin autoimmunity: Associated neurological syndromes and tumors in the Turkish population. (2010): 121 - 126.
MLA Tuzun Erdem,BEBEK Nerses,içöz sema,DURMUŞ TEKÇE Hacer,KÜRTÜNCÜ Murat,Gurses Candan,AKMAN-DEMİR Gülşen Amphiphysin autoimmunity: Associated neurological syndromes and tumors in the Turkish population. , 2010, ss.121 - 126.
AMA Tuzun E,BEBEK N,içöz s,DURMUŞ TEKÇE H,KÜRTÜNCÜ M,Gurses C,AKMAN-DEMİR G Amphiphysin autoimmunity: Associated neurological syndromes and tumors in the Turkish population. . 2010; 121 - 126.
Vancouver Tuzun E,BEBEK N,içöz s,DURMUŞ TEKÇE H,KÜRTÜNCÜ M,Gurses C,AKMAN-DEMİR G Amphiphysin autoimmunity: Associated neurological syndromes and tumors in the Turkish population. . 2010; 121 - 126.
IEEE Tuzun E,BEBEK N,içöz s,DURMUŞ TEKÇE H,KÜRTÜNCÜ M,Gurses C,AKMAN-DEMİR G "Amphiphysin autoimmunity: Associated neurological syndromes and tumors in the Turkish population." , ss.121 - 126, 2010.
ISNAD Tuzun, Erdem vd. "Amphiphysin autoimmunity: Associated neurological syndromes and tumors in the Turkish population". (2010), 121-126.
APA Tuzun E, BEBEK N, içöz s, DURMUŞ TEKÇE H, KÜRTÜNCÜ M, Gurses C, AKMAN-DEMİR G (2010). Amphiphysin autoimmunity: Associated neurological syndromes and tumors in the Turkish population. Journal of Neurological Sciences (Turkish), 27(2), 121 - 126.
Chicago Tuzun Erdem,BEBEK Nerses,içöz sema,DURMUŞ TEKÇE Hacer,KÜRTÜNCÜ Murat,Gurses Candan,AKMAN-DEMİR Gülşen Amphiphysin autoimmunity: Associated neurological syndromes and tumors in the Turkish population. Journal of Neurological Sciences (Turkish) 27, no.2 (2010): 121 - 126.
MLA Tuzun Erdem,BEBEK Nerses,içöz sema,DURMUŞ TEKÇE Hacer,KÜRTÜNCÜ Murat,Gurses Candan,AKMAN-DEMİR Gülşen Amphiphysin autoimmunity: Associated neurological syndromes and tumors in the Turkish population. Journal of Neurological Sciences (Turkish), vol.27, no.2, 2010, ss.121 - 126.
AMA Tuzun E,BEBEK N,içöz s,DURMUŞ TEKÇE H,KÜRTÜNCÜ M,Gurses C,AKMAN-DEMİR G Amphiphysin autoimmunity: Associated neurological syndromes and tumors in the Turkish population. Journal of Neurological Sciences (Turkish). 2010; 27(2): 121 - 126.
Vancouver Tuzun E,BEBEK N,içöz s,DURMUŞ TEKÇE H,KÜRTÜNCÜ M,Gurses C,AKMAN-DEMİR G Amphiphysin autoimmunity: Associated neurological syndromes and tumors in the Turkish population. Journal of Neurological Sciences (Turkish). 2010; 27(2): 121 - 126.
IEEE Tuzun E,BEBEK N,içöz s,DURMUŞ TEKÇE H,KÜRTÜNCÜ M,Gurses C,AKMAN-DEMİR G "Amphiphysin autoimmunity: Associated neurological syndromes and tumors in the Turkish population." Journal of Neurological Sciences (Turkish), 27, ss.121 - 126, 2010.
ISNAD Tuzun, Erdem vd. "Amphiphysin autoimmunity: Associated neurological syndromes and tumors in the Turkish population". Journal of Neurological Sciences (Turkish) 27/2 (2010), 121-126.