Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia
Yıl: 2012 Cilt: 28 Sayı: 1 Sayfa Aralığı: 21 - 26 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022
Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia
Öz: Amaç: Lipopolisakkarit ile deneysel endotoksemi oluşturulan buzağılarda akut faz proteinlerin ve klinik değişimlerin belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmada yaşları 25-42 gün arasında değişen sekiz adet Holstein ırkı buzağı kullanıldı. Lipopolisakkarit damar içi 0.1 μg/kg dozunda 50 mL % 0.9 NaCl’de seyreltilip 30 dakika süresince verilerek endotoksemi oluşturuldu. Çalışma boyunca endotoksemi gelişen buzağılarda klinik olarak gözlenen değişiklikler kayıt edilirken ve akut faz proeinlerinin konsantrasyonları belirlendi. Bulgular: Lipopolisakkarit uygulanması sonrasında buzağıların tamamında solunum sayısında ve kalp atım sayısında artış, yerde yatma, depresyon, hipotermi/hipertermi mukozada hiperemi/siyanoz ve emme refleksinde azalma gözlendi. Klinik olarak gelişen değişimler 1. ve 3. saatler arasında daha şiddetli olduğu belirlendi. Damar içi lipopolisakkarit verilmesinden sonra haptoglobin 36. saatte (500±93.2 μg/ mL) ve serum amyloid-A 24. saatte (185± 46.6 μg/mL) en üst seviyeye ulaştı. Öneri: Akut faz proteinlerde ve klinik bulgulardaki gözlenen değişim, buzağılarda gelişen endotoksemi ile ilişkilidir. Buzağılarda serum haptoglobin ve serum amyloid-A konsantrasyonlardaki artışlar endotokseminin bir belirteçi olarak değerlendirilebilir.
Anahtar Kelime: Konular:
Lipopolisakkarit ile endotoksemi oluşturulan buzağılarda akut faz cevap ve klinik değişimler
Öz: Aim: The purpose of the study was to determine the levels of acute phase proteins and clinical changes in calves with lipopolysaccharide induced experimental endotoxemia. Materials and Methods: Eight Holstein breed calves were used in the study. Endotoxemia was induced via intravenous administration of 0.1 μg/kg dose of lipopolysaccharide in 50 mL of physiological 0.9% NaCl over 30 min. The calves were continuously observed for clinical changes during the experiment, and serum acute phase protein levels were measured. Results: Increase in respiratory frequency, tachycardi, mucosal hyperemia/cyanosis, recumbency, depression, hyperthermia/hypothermia, and poor suckle reflexes were observed in all calves after lipopolysaccharide administration. After lipopolysaccharide infusion, serum haptoglobin (500±93.2 μg/mL) and serum amyloid A (185±46.6) concentrations reached peak levels of at 36 h and 24 h, respectively. Conclusion: Changes in acute phase proteins and clinical findings were related to endotoxemia. A moderate to high increase in haptoglobin and serum amyloid A concentrations may indicate the presence of endotoxemia in calves.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | COŞKUN A, SEN l (2012). Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia. , 21 - 26. |
| Chicago | COŞKUN Alparslan,SEN lsmail Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia. (2012): 21 - 26. |
| MLA | COŞKUN Alparslan,SEN lsmail Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia. , 2012, ss.21 - 26. |
| AMA | COŞKUN A,SEN l Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia. . 2012; 21 - 26. |
| Vancouver | COŞKUN A,SEN l Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia. . 2012; 21 - 26. |
| IEEE | COŞKUN A,SEN l "Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia." , ss.21 - 26, 2012. |
| ISNAD | COŞKUN, Alparslan - SEN, lsmail. "Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia". (2012), 21-26. |
| APA | COŞKUN A, SEN l (2012). Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia. Eurasian Journal of Veterinary Sciences, 28(1), 21 - 26. |
| Chicago | COŞKUN Alparslan,SEN lsmail Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia. Eurasian Journal of Veterinary Sciences 28, no.1 (2012): 21 - 26. |
| MLA | COŞKUN Alparslan,SEN lsmail Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia. Eurasian Journal of Veterinary Sciences, vol.28, no.1, 2012, ss.21 - 26. |
| AMA | COŞKUN A,SEN l Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia. Eurasian Journal of Veterinary Sciences. 2012; 28(1): 21 - 26. |
| Vancouver | COŞKUN A,SEN l Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia. Eurasian Journal of Veterinary Sciences. 2012; 28(1): 21 - 26. |
| IEEE | COŞKUN A,SEN l "Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia." Eurasian Journal of Veterinary Sciences, 28, ss.21 - 26, 2012. |
| ISNAD | COŞKUN, Alparslan - SEN, lsmail. "Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia". Eurasian Journal of Veterinary Sciences 28/1 (2012), 21-26. |
