This cross-sectional, analytic study was conducted to investigate the depression and factors affecting the quality of life in the relatives of the patients with cancer. The sample of the study consisted of 110 relatives of the cancer patients who were treated at the Department of Medical Oncology of Meram Medical Faculty of Selçuk University. WHOQOL-Bref’s scale of quality of life was used to measure the patients’ quality of life. Depression status was evaluated with Beck depression inventory. Of the interviewers, 53.6% were male, 46.4% female, 86.4% married, 55.5% primary school educated, and the mean age was 47.3±13.5 years and 44.5% were the offsprings of the cancer patients. The mean value of Beck depresyon inventory was 8.0±7.7. According to the values of the inventory, 65.5% were normal, 24.5% mildly, 7.3% moderately and 2.7% severely depressed. The gender, occupation, education and marital status of the relatives of the cancer patients did not affect the depression status (p>0.05). When we compared the quality of life scores and depression status, there were significant differences in psychological health (p=0.000), perception of overall health and the satisfaction from life (p=0.002), general health and the quality of life (p=0.008), physical health (p=0.001) and environmental area (p=0.025) while there was no statistically significant difference in social relationships (p=0.089) between the cases with and without depression. Cancer is an important health problem for both the cancer patients and their relatives. The relatives of cancer patients would inevitably be affected by the cancer patients psychologically. Anxiety and depression are the major concerns in these cases, and empathic approach of physicians and health care personnel is necessary to cope with these problems.