Anti-diarrheal activity and acute toxicity of methanolic bark extract of adenanthera pavonina linn (fabaceae) and its elemental composition

AHMED, Nazım Uddin; SALEH-E-IN, Moshfekus; ARA, Arzumand; HASHEM, Abul; BACHAR, Sitesh Chandra

Anti-diarrheal activity and acute toxicity of methanolic bark extract of adenanthera pavonina linn (fabaceae) and its elemental composition

Arzumand ARA, (Jahangirnagar University, Department of Chemistry, Savar, Dhaka 1342, Bangladesh)

Moshfekus SALEH-E-IN, (Jahangirnagar University, Department of Chemistry, Savar, Dhaka 1342, Bangladesh)

Nazım Uddin AHMED, (BCSIR Laboratories Dhaka, Dhanmondi, Dhaka 1205, Bangladesh)

Abul HASHEM, (Jahangirnagar University, Department of Chemistry, Savar, Dhaka 1342, Bangladesh)

Sitesh Chandra BACHAR (University of Dhaka, Faculty of Pharmacy, Department of Pharmaceutical Technology, Dhaka 1000, Bangladesh)

Turkish Journal of Pharmaceutical Sciences

1 0

Yıl: 2013 Cilt: 10 Sayı: 2 Sayfa Aralığı: 263 - 272 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Anti-diarrheal activity and acute toxicity of methanolic bark extract of adenanthera pavonina linn (fabaceae) and its elemental composition

Öz:

Adenanthera pavonina L. Banglades 'te halk arasında ve geleneksel tedavide astım, diyare, gut, inflamasyonlar, romatizma, tumor, ülserlerin tedavisinde ve tonik olarak kullamlmaktadır. Sıçanlarda hint yagi He oluşturulan diyare modelinde, A. pavonina kabuğunun metanollü ekstresi kümülatif yaş feçes kütlesini doza bağlı olarak belirgin olarak azaltmıştır. Kontrol grubu ile karşılaştırıldığında, 500 mg/kg vücut ağırlığında azalma % 17.91 ve 1000 mg/kg vücut ağırlığında % 34.32 azalma bulunmuştur. Fareler üzerinde yapılan akut toksisite çalışmasında, metanollü ekstrenin LD50 değeri 1453.44 mg/kg olarak bulunmuştur. Toz edilmiş kabuk örneğinde N, P, K, S, Ca ve Mg elementlerinin yüksek miktarlarda olduğu bulunmuştur. Gözlenen aktiviteler ve bunun yanında kabuğun mineral kompozisyonu doğal bileşiklere dayalı farmasötik ürün geliştirmek için farmakolojik potansiyeli olduğunu göstermiş ve aynı zamanda ayurvedik tıpta geleneksel kullammını desteklemiştir.

Anahtar Kelime:

Konular: Farmakoloji ve Eczacılık

Adenanthera pavonina Linn mn (Fabaceae) metanollü kabuk ekstresinin antidiyareyik aktivitesi, akut toksisitesi ve bitkinin elementel kompozisyonu

Öz:

In folk and traditional medicine in Bangladesh, Adenanthera pavonina L. has been used for the treatment of asthma, diarrhea, gout, inflammations, rheumatism, tumour, ulcers and as a tonic. In castor oil induced diarrhea model on rat, the methanol extract of A. pavonina bark has significantly reduced the cumulative wet fecal mass in the dose dependant protection. At the doses of 500 mg/kg body weight found 17.91% reduction and at 1000 mg/kg body weight found 34.32% reduction in comparison to the control. In acute toxicity study on mice, the LD50 value of the methanolic extract was found to be 1453.44 mg/kg. The elements N, P, K, S, Ca and Mg were found to be the highest amount of the powdered bark sample. The observed activities as well as mineral composition of the bark powder possesses pharmacological potential to develop natural compounds based pharmaceutical products and also justifies its use in traditional ayurve dic form of medicine.

Anahtar Kelime:

Konular: Farmakoloji ve Eczacılık

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Devendra BN, Srinivas N, Solmon KS, A comparative pharmacological analysis of in vitro and in vivo propagated Crotalaria species, Asian Pacific Journal of Tropical Medicine 5(1), 37-41, 2012.
2. Burkil HM, The useful plants of West Tropical Africa, Vol 2, Royal Botanical Gardens, Kew, London, 1994.
3. Kirtikar KR, Basu BD, Indian Medicinal Plants (2nd Ed.), International Book Distributors, India, pp. 1710, 1981.
4. Watt JM, Breyer-Brandwijk MG, The medicinal and poisonous plants of Southern and Eastern Africa, 2nd ed., E and S Livingstone Ltd., London, 1962.
5. Anonymous, The wealth of India, A dictionary of Indian Raw Materials and Industrial Products, Vol. IA, CSIR, New Delhi, India, 1985.
6. Ghani A, Medicinal Plants of Bangladesh (chemical constituents and uses), 2nd Ed., pp. 331-332, Published by Asiatic Society of Bangladesh, Dhaka 1000, Bangladesh, 2003.
7. Yadev N, Misra G, Nigam SK, Triterpenoids of Adenanthera pavonina bark, Planta Medica 29(2), 176-178, 1976.
8. Yeoh HH, Wee YC, Watson L, Systematic variation of leaf amino acid compositions of leguminous plants, Phytochemistry 23(10), 2227-2229, 1984.
9. Chandra S, Verma M, Saxena H, Triterpenoids of Adenanthera pavonina root, International Journal of Crude Drug Research 20, 165-167, 1982.
10. Mesbah UA, Ataur RM, Tabassum R, Nahar K, Chemical constituents of the leaves of Adenanthera pavonina L, J Bangladesh Chem Soc 15(2), 194-199, 2002.
11. Shaiq AM, Ahmed F, Azhar I, Pervez MK, Pavinin: A new five membered lactone from Adenanthera pavonina L. (Mimoaceae), Natural Product Research, 19 (1), 37-40, 2005.
12. Enuo Y, Shishan PY, Studies on chemical constituents from stems and leaves of Adenanthera pavonina L, Zhongguo Zhongyao Zazhi 32(20), 2135-2138, 2007.
13. Ara A, Saleh-e-In MM, Ahmed NU, Ahmed M, Hashem MA, Bachar SC, Phytochemical screening, analgesic, antimicrobial, and anti-oxidant activities of bark extracts of Adenanthera pavonina L. (Fabaceae), Advances in Natural and Applied Sciences 4(3), 352-360, 2010.
14. Adedapo ADA, Osude YO, Adedapo AA, Moody JO, Adeagbo AS, Olajide OA, Makinde JM, Blood pressure lowering effect of Adenanthera pavonina seed extract on normotensive rats, Records of Natural Products 3, 82-89, 2009.
15. Nigam SK, Misra G, Mitra CR, Stigmasterol glucosides constituents of Adenanthera pavonina seed and leaf, Planta Medica 23(2), 145-8, 1973.
16. Neerja Y, Gopal M, Nigam SK, Triterpenoids of Adenanthera pavonina bark, Planta Medica 29(2), 176-178, 1976.
17. Rodrigo SK, Jayasingha ULB, Bandara BMR, Antifungal, antioxidant and cytotoxic activity of Acronychia pedunculata and Adenanthera pavonina, Proceeding of the Peradeniya University Research Sessions-Sri Lanka 12(1), 9495, 2007.
18. Jayasinghe PKIDE, Bandara BMR, Ekanayaka EWMA, Thevanesam V, Screening for antimicrobial activity of Acronychia pedunculata (Ankenda) and Adenanthera pavonina (Madatiya) against bacteria causing skin and wound infections in humans, Proceedings of the Peradeniya University Research Sessions-Sri Lanka 11, 105, 2006.
19. Olajide OA, Echianu CA, Adedapo ADA, Makinde JM, Antiinflammatory studies on Adenanthera pavonina seed extract, Inflammopharmacol 12(2), 196-202, 2004.
20. Mayuren C. Ilavarasan R, Anti-inflamatory activity of ethanolic leaf extracts from Adenanthera pavonina (L) in rat, Journal of Young Pharmacist 1(2), 125-128, 2009.
21. Arzumand A, Arifuzzaman M, Ghosh CK, Hashem MA, Ahmad MU, Bachar SC, Nahar L, Sarker SD, Anti-inflammatory activity of Adenanthera pavonina L., Fabaceae, in experimental animals, Brazilian Journal of Pharmacognosy 20(6), 929-932, 2010.
22. Chitme HR, Chandra R, Kaushik S, Studies on anti-diarrheal activity of Calotropis gigantean in experimental animals, J Pharmacol Pharm Sci 7, 70-75, 2004.
23. Osarenmwinda IP, Omonkhelin JO, Ejiro D, Antidiarrhoeal activity of the methanolic extract of the leaves of Paullina pinnata Linn. (Sapindaceae), The Internet Journal of Health 9(1), 2009.
24. Adeyemi OO, Okpo SO, Adesanya AA, Gastrointestinal activity of the aqueous extract of a Nigerian polyherbal preparation, West African Journal of Pharmacology and Drug Research 19, 22-27, 2003.
25. Shoba FG, Thomas M, Study of antidiarrhoeal activity of four medicinal plants in castor oil induced diarrhea, J Ethnopharmacol 76, 73-76, 2001.
26. Zaoui A, Cherrah Y, Mahassini N, Alaovi K, Amarouch H, Hassar M, Acute and chronic toxicity of Nigella sativa fixed oil, Phytomedicine 9, 69-74, 2002.
27. Finney DJ, Probit Analysis, 3rd edition, p.333, Cambridge University Press, London, 1971.
28. AOAC, Official Methods of Analysis. Association of Official Analytical Chemists, 18th Ed., Washington DC, 2005.
29. Couper IM, Inhibition of intestinal motility and the secretion by flavonoids in mice and in rats: structural activity relationship, J Pharm Pharmacol 45, 1054-1059, 1987.
30. Sule MI, Nijinga NS, Musa AM, Magaji MG, Abdullahi A, Phytochemical and antidiarrhoeal studies of the stem bark of Ceiba pentandra (Bombacacaceae), Nigerian Journal of Pharmaceutical Sciences 8(1), 143-148, 2009.
31. Mascolo N, Izzo AA, Gaginella TS, Capasso F, Relationship between nitric oxide and platelet activating factor in castor oil-induced mucosal injury in the rat duodenum, Naunyn Schmiedebergs Arch Pharmacol 353, 680-684, 1996.
32. Mascolo N, Izzo AA, Autore G, Barbato F, Capasso F, Nitric oxide and castor oil-induced diarrhea, Am Soc Pharmacol Exp Ther 268, 291-295, 1994.
33. Ammon HV, Thomas PJ, Phillips S, Effect of oleic and ricinoleic acid on net jejunal water and electrolyte movement, J Clin Invest 53, 374-379, 1974.
34. Zavala MA, Perez S, Perez C, Vargas B, Perez RM, Antidiarrheal activity of Walfheria americana, Commelina coelestis and Alternanthera repens, J Ethnopharmacol 61, 41-47, 1998.
35. Longanga O, Vercruysse AA, Foriers A, Contribution to the ethno-botanical, phytochemical and pharmacological studies of traditionally used medicinal plant in the treatment of dysentery and diarrhoea in Lomela area, Democratic Republic of Congo (DRC), J Ethnopharmacol 71(3), 411-423, 2000.
36. Veiga VF, Zunino L, Calixto JB, Pititucci ML, Pinato AC, Phytochemical and antioedematogenic studies of commercial copaiba oils available in Brazil, Phytother Res 15(6), 476-480, 2001.

APA	ARA A, SALEH-E-IN M, AHMED N, HASHEM A, BACHAR S (2013). Anti-diarrheal activity and acute toxicity of methanolic bark extract of adenanthera pavonina linn (fabaceae) and its elemental composition. , 263 - 272.
Chicago	ARA Arzumand,SALEH-E-IN Moshfekus,AHMED Nazım Uddin,HASHEM Abul,BACHAR Sitesh Chandra Anti-diarrheal activity and acute toxicity of methanolic bark extract of adenanthera pavonina linn (fabaceae) and its elemental composition. (2013): 263 - 272.
MLA	ARA Arzumand,SALEH-E-IN Moshfekus,AHMED Nazım Uddin,HASHEM Abul,BACHAR Sitesh Chandra Anti-diarrheal activity and acute toxicity of methanolic bark extract of adenanthera pavonina linn (fabaceae) and its elemental composition. , 2013, ss.263 - 272.
AMA	ARA A,SALEH-E-IN M,AHMED N,HASHEM A,BACHAR S Anti-diarrheal activity and acute toxicity of methanolic bark extract of adenanthera pavonina linn (fabaceae) and its elemental composition. . 2013; 263 - 272.
Vancouver	ARA A,SALEH-E-IN M,AHMED N,HASHEM A,BACHAR S Anti-diarrheal activity and acute toxicity of methanolic bark extract of adenanthera pavonina linn (fabaceae) and its elemental composition. . 2013; 263 - 272.
IEEE	ARA A,SALEH-E-IN M,AHMED N,HASHEM A,BACHAR S "Anti-diarrheal activity and acute toxicity of methanolic bark extract of adenanthera pavonina linn (fabaceae) and its elemental composition." , ss.263 - 272, 2013.
ISNAD	ARA, Arzumand vd. "Anti-diarrheal activity and acute toxicity of methanolic bark extract of adenanthera pavonina linn (fabaceae) and its elemental composition". (2013), 263-272.

APA	ARA A, SALEH-E-IN M, AHMED N, HASHEM A, BACHAR S (2013). Anti-diarrheal activity and acute toxicity of methanolic bark extract of adenanthera pavonina linn (fabaceae) and its elemental composition. Turkish Journal of Pharmaceutical Sciences, 10(2), 263 - 272.
Chicago	ARA Arzumand,SALEH-E-IN Moshfekus,AHMED Nazım Uddin,HASHEM Abul,BACHAR Sitesh Chandra Anti-diarrheal activity and acute toxicity of methanolic bark extract of adenanthera pavonina linn (fabaceae) and its elemental composition. Turkish Journal of Pharmaceutical Sciences 10, no.2 (2013): 263 - 272.
MLA	ARA Arzumand,SALEH-E-IN Moshfekus,AHMED Nazım Uddin,HASHEM Abul,BACHAR Sitesh Chandra Anti-diarrheal activity and acute toxicity of methanolic bark extract of adenanthera pavonina linn (fabaceae) and its elemental composition. Turkish Journal of Pharmaceutical Sciences, vol.10, no.2, 2013, ss.263 - 272.
AMA	ARA A,SALEH-E-IN M,AHMED N,HASHEM A,BACHAR S Anti-diarrheal activity and acute toxicity of methanolic bark extract of adenanthera pavonina linn (fabaceae) and its elemental composition. Turkish Journal of Pharmaceutical Sciences. 2013; 10(2): 263 - 272.
Vancouver	ARA A,SALEH-E-IN M,AHMED N,HASHEM A,BACHAR S Anti-diarrheal activity and acute toxicity of methanolic bark extract of adenanthera pavonina linn (fabaceae) and its elemental composition. Turkish Journal of Pharmaceutical Sciences. 2013; 10(2): 263 - 272.
IEEE	ARA A,SALEH-E-IN M,AHMED N,HASHEM A,BACHAR S "Anti-diarrheal activity and acute toxicity of methanolic bark extract of adenanthera pavonina linn (fabaceae) and its elemental composition." Turkish Journal of Pharmaceutical Sciences, 10, ss.263 - 272, 2013.
ISNAD	ARA, Arzumand vd. "Anti-diarrheal activity and acute toxicity of methanolic bark extract of adenanthera pavonina linn (fabaceae) and its elemental composition". Turkish Journal of Pharmaceutical Sciences 10/2 (2013), 263-272.