Objectives: We assessed the quality of life of patients who were leading a disease-free life in the long-term follow-up after surgical treatment for laryngeal cancer. Patients and Methods: Sixty-six consecutive patients (4 women, 62 men; mean age 57 years; range 37 to 73 years) were evaluated by the University of Washington Quality of Life Questionnaire and Comparative Quality of Life assessment. All the patients underwent primary surgery for laryngeal cancer and were disease-free after at least 12 months following the completion of their treatment. The results were compared with those of 32 demographically matched healthy subjects. The patients were also divided into two subgroups, namely surgery with permanent tracheostomy (n-32) or without tracheostomy (n=34). Results: Quality of life was rated as similar to (n-50, 76%), worse than (n=15, 23%), and much worse than (n=1, 2%), that present one year prior to diagnosis. Speech and pain scores and the surgical method employed were found to significantly affect the comparative quality of life assessment (p=0.0001, p=0.03 and p=0.0002, respectively).Conclusion: In order to improve the quality of life of patients with laryngeal cancer, emphasize should be given to treatment modalities that are adherent to oncological principles, but enable preservation or restoration of voice, with minimum loss of shoulder function.