Can neutrophil/lymphocyte ratio predict recurrence of non-valvular atrial fibrillation after cardioversion?

GÖK, HASAN; ÖZDEMİR, Kurtuluş; KAYRAK, Mehmet; ARIBAŞ, Alpay; YAZICI, Mehmet; DUMAN, Çetin; Demir, Kenan; Gul, Enes; ALIBASIÇ, Hajrudin; AKILLI, Hakan

Can neutrophil/lymphocyte ratio predict recurrence of non-valvular atrial fibrillation after cardioversion?

Alpay ARIBAŞ, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Konya, Türkiye)

Hakan AKILLI, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Konya, Türkiye)

Enes Elvin GÜL, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Konya, Türkiye)

Mehmet KAYRAK, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Konya, Türkiye)

Kenan DEMİR, (Selçuk Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Konya, Türkiye)

Çetin DUMAN, (Sağlık Bakanlığı, Akşehir Devlet Hastanesi, Kardiyoloji Kliniği, Konya, Türkiye)

Hajrudin ALIBASIÇ, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Konya, Türkiye)

Mehmet YAZICI, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Konya, Türkiye)

Kurtuluş ÖZDEMİR, (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Konya, Türkiye)

Hasan GÖK (Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Konya, Türkiye)

Anadolu Kardiyoloji Dergisi

2 1

Yıl: 2013 Cilt: 13 Sayı: 2 Sayfa Aralığı: 123 - 130 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Can neutrophil/lymphocyte ratio predict recurrence of non-valvular atrial fibrillation after cardioversion?

Öz:

Amaç: Yüksek nötrofil/lenfosit oranının (NLO) koroner arter baypas cerrahisi sonrası atriyal fibrilasyon (AF) gelişmesiyle ilişkili olduğu gösterilmiştir. Bu çalışmada NLO’nın kapak hastalığının eşlik etmediği AF’de elektriki kardiyoversiyon (KV) sonrası nüksü öngördürmede etkinliği araştırıldı. Yöntemler: Bu prospektif kohort çalışmasına, elektriki KV sonrası başarılı olunan toplam 149 hasta alındı. Tüm hastaların KV öncesi; kişisel bilgileri kaydedildi, tam kan sayımı, alışılagelen biyokimyasal tetkikleri ve yüksek duyarlılıklı C-reaktif protein (hs-CRP) çalışıldı. İşlem öncesi ekokardiyografik ölçümleri kaydedildi. KV sonrası hastalar rekürrens açısından altı ay takip edildi. Nüks gelişen grubun bazal karakteristikleri sinüs grubu ile Student t- testi kullanılarak karşılaştırıldı. Rekürrensin bağımsız öngördürücüleri lojistik regresyon analizi ile araştırıldı. Bulgular: Kırk altı hastada (%30.9) nüks izlendi. Nüks grubunda AF süresi [ortanca: 16 (çeyrekler arası aralık (ÇAA): 14.25]’e karşın, ortanca: 12 (ÇAA: 11) ay, p=0.01) ve sol atriyum (SA) çapı (4.5±0.4 cm’e karşın, 4.3±0.5 cm, p=0.023) belirgin uzun bulundu. Nüks gurubunda, sinus ritmine oranla başlangıç hs-CRP değerleri belirgin yüksek (ortanca: 9.80’e (ÇAA: 8.50) karşın ortanca: 4.28 (ÇAA: 5.65) mg/dL, p=0.002) iken, NLO her iki grupta benzerdi. [rekürrens grubunda ortanca: 2.38 (ÇAA: 2.09), sinüs grubunda ortanca:2.23 (ÇAA: 1.23), p=0.96]. NLO ile hs-CRP seviyeleri (r=0.22, p=0.05) ve yaş (r=0.24, p=0.02) arasında zayıf bir pozitif ilişki mevcuttu. Çoklu lojistik regresyon analizinde hs-CRP [OO: 1.34 (1.09-1.65 %95 GA)] p=0.006) SA çapı [OO: 11.92 (1.84-77.07 %95 GA) p=0.01], spontan eko kontrast varlığı [OO: 5.40 (1.04-12.02 %95 GA) p=0.045] ve sisto- lik kan basıncı [OO: 1.05 (1.01-1.10 %95 GA) p=0.03] nüksün bağımsız öngördürücüleri olarak izlendi. Sonuç: NLO başarılı kardiyoversiyon sonrası AF nüksünü öngördürmede etkisiz bulunmuştur. Hs-CRP başarılı kardiyoversiyon sonrası nüksü öngördürmede etkin olarak kullanılabilir.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Nötrofil/lenfosit oranı kapak hastalığının eşlik etmediği atriyal fibrilasyonda elektriki kardiyoversiyon sonrası nüksü öngördürebilir mi?

Öz:

Objective: High neutrophil/lymphocyte ratio (NLR) has been associated with post-operative AF development in patients who underwent cardiac surgery. In this study, effectiveness of NLR for prediction of recurrence after electrical cardioversion (CV) in non-valvular AF was investigated. Methods: A total of 149 patients who underwent a successful CV were included in this prospective cohort study. Baseline complete blood cell count, routine biochemical tests, high sensitive C-reactive protein (hs-CRP), and echocardiographic measurements were examined. After CV, patients were monitored over six months for recurrence. Baseline characteristics of recurrence group were compared with sinus rhythm group by using Student`s t -test. Logistic regression analysis was used to determine predictors of recurrence. Results: Recurrence occurred in a total of 46 patients (30.9%). Median AF duration [16 (IQR:14.25) vs. 12 (IQR:11) months, p=0.01], baseline hs- CRP [9.80 (IQR: 8.50) mg/dL vs. 4.28 (IQR: 5.65) mg/dL, p=0.002] and left atrium (LA) diameter (4.5±0.4 cm, 4.3±0.5 cm, p=0.023) were significantly higher in the recurrence group than sinus rhythm group. Median NLR was comparable in recurrence and sinus groups [2.38 (IQR: 2.09) vs. 2.23, (IQR: 1.23) p=0.96, respectively]. There was a weak correlation between NLR and hs-CRP (r=0.22, p=0.05) and age (r=0.24, p=0.02). In multiple logistic regression analysis, hs-CRP [OR: 1.34 (1.09-1.65 95% CI) p=0.006], LA diameter [OR: 11.92 (1.84-77.07 95% CI) p=0.01], spontaneous echo contrast positivity, [OR: 5.40 (1.04-12.02 95% CI) p=0.045] and systolic blood pressure [OR: 1.05 (1.01-1.10 95% CI) p=0.03] were independent predictors of AF recurrence. Conclusion: NLR failed to predict AF recurrence after a successful electrical CV, but hs-CRP remained an inflammatory marker of AF recur-rence.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ARIBAŞ A, AKILLI H, Gul E, KAYRAK M, Demir K, DUMAN Ç, ALIBASIÇ H, YAZICI M, ÖZDEMİR K, GÖK H (2013). Can neutrophil/lymphocyte ratio predict recurrence of non-valvular atrial fibrillation after cardioversion?. , 123 - 130.
Chicago	ARIBAŞ Alpay,AKILLI Hakan,Gul Enes,KAYRAK Mehmet,Demir Kenan,DUMAN Çetin,ALIBASIÇ Hajrudin,YAZICI Mehmet,ÖZDEMİR Kurtuluş,GÖK HASAN Can neutrophil/lymphocyte ratio predict recurrence of non-valvular atrial fibrillation after cardioversion?. (2013): 123 - 130.
MLA	ARIBAŞ Alpay,AKILLI Hakan,Gul Enes,KAYRAK Mehmet,Demir Kenan,DUMAN Çetin,ALIBASIÇ Hajrudin,YAZICI Mehmet,ÖZDEMİR Kurtuluş,GÖK HASAN Can neutrophil/lymphocyte ratio predict recurrence of non-valvular atrial fibrillation after cardioversion?. , 2013, ss.123 - 130.
AMA	ARIBAŞ A,AKILLI H,Gul E,KAYRAK M,Demir K,DUMAN Ç,ALIBASIÇ H,YAZICI M,ÖZDEMİR K,GÖK H Can neutrophil/lymphocyte ratio predict recurrence of non-valvular atrial fibrillation after cardioversion?. . 2013; 123 - 130.
Vancouver	ARIBAŞ A,AKILLI H,Gul E,KAYRAK M,Demir K,DUMAN Ç,ALIBASIÇ H,YAZICI M,ÖZDEMİR K,GÖK H Can neutrophil/lymphocyte ratio predict recurrence of non-valvular atrial fibrillation after cardioversion?. . 2013; 123 - 130.
IEEE	ARIBAŞ A,AKILLI H,Gul E,KAYRAK M,Demir K,DUMAN Ç,ALIBASIÇ H,YAZICI M,ÖZDEMİR K,GÖK H "Can neutrophil/lymphocyte ratio predict recurrence of non-valvular atrial fibrillation after cardioversion?." , ss.123 - 130, 2013.
ISNAD	ARIBAŞ, Alpay vd. "Can neutrophil/lymphocyte ratio predict recurrence of non-valvular atrial fibrillation after cardioversion?". (2013), 123-130.

APA	ARIBAŞ A, AKILLI H, Gul E, KAYRAK M, Demir K, DUMAN Ç, ALIBASIÇ H, YAZICI M, ÖZDEMİR K, GÖK H (2013). Can neutrophil/lymphocyte ratio predict recurrence of non-valvular atrial fibrillation after cardioversion?. Anadolu Kardiyoloji Dergisi, 13(2), 123 - 130.
Chicago	ARIBAŞ Alpay,AKILLI Hakan,Gul Enes,KAYRAK Mehmet,Demir Kenan,DUMAN Çetin,ALIBASIÇ Hajrudin,YAZICI Mehmet,ÖZDEMİR Kurtuluş,GÖK HASAN Can neutrophil/lymphocyte ratio predict recurrence of non-valvular atrial fibrillation after cardioversion?. Anadolu Kardiyoloji Dergisi 13, no.2 (2013): 123 - 130.
MLA	ARIBAŞ Alpay,AKILLI Hakan,Gul Enes,KAYRAK Mehmet,Demir Kenan,DUMAN Çetin,ALIBASIÇ Hajrudin,YAZICI Mehmet,ÖZDEMİR Kurtuluş,GÖK HASAN Can neutrophil/lymphocyte ratio predict recurrence of non-valvular atrial fibrillation after cardioversion?. Anadolu Kardiyoloji Dergisi, vol.13, no.2, 2013, ss.123 - 130.
AMA	ARIBAŞ A,AKILLI H,Gul E,KAYRAK M,Demir K,DUMAN Ç,ALIBASIÇ H,YAZICI M,ÖZDEMİR K,GÖK H Can neutrophil/lymphocyte ratio predict recurrence of non-valvular atrial fibrillation after cardioversion?. Anadolu Kardiyoloji Dergisi. 2013; 13(2): 123 - 130.
Vancouver	ARIBAŞ A,AKILLI H,Gul E,KAYRAK M,Demir K,DUMAN Ç,ALIBASIÇ H,YAZICI M,ÖZDEMİR K,GÖK H Can neutrophil/lymphocyte ratio predict recurrence of non-valvular atrial fibrillation after cardioversion?. Anadolu Kardiyoloji Dergisi. 2013; 13(2): 123 - 130.
IEEE	ARIBAŞ A,AKILLI H,Gul E,KAYRAK M,Demir K,DUMAN Ç,ALIBASIÇ H,YAZICI M,ÖZDEMİR K,GÖK H "Can neutrophil/lymphocyte ratio predict recurrence of non-valvular atrial fibrillation after cardioversion?." Anadolu Kardiyoloji Dergisi, 13, ss.123 - 130, 2013.
ISNAD	ARIBAŞ, Alpay vd. "Can neutrophil/lymphocyte ratio predict recurrence of non-valvular atrial fibrillation after cardioversion?". Anadolu Kardiyoloji Dergisi 13/2 (2013), 123-130.