Serum Cardiac Troponin-I in dogs with CPV-2 infection

OZEN, DOGUKAN; BASTAN, IDIL; KURTDEDE, ARIF; TIMURKAN, M. Özkan; Yumusak, Nihat; SEL, Tevhide; BAYDIN, Ahmet

Serum Cardiac Troponin-I in dogs with CPV-2 infection

İdil BAŞTAN, (Ankara Üniversitesi, Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Arif KURTDEDE, (Ankara Üniversitesi, Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Ahmet BAYDIN, (Ankara Üniversitesi, Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Tevhide SEL, (Ankara Üniversitesi, Veteriner Fakültesi, Biyokimya Anabilim Dalı, Ankara, Türkiye)

Doğukan ÖZEN, (Ankara Üniversitesi, Veteriner Fakültesi, Biyoistatistik Anabilim Dalı, Ankara, Türkiye)

Nihat YUMUŞAK, (Harran Üniversitesi, Veteriner Fakültesi, Patoloji Anabilim Dalı, Şanlıurfa, Türkiye)

M. Özkan TIMURKAN (Atatürk Üniversitesi, Veteriner Fakültesi, Viroloji Anabilim Dalı, Erzurum, Türkiye)

Ankara Üniversitesi Veteriner Fakültesi Dergisi

19 0

Yıl: 2013 Cilt: 60 Sayı: 4 Sayfa Aralığı: 251 - 255 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Serum Cardiac Troponin-I in dogs with CPV-2 infection

Öz:

Özet: Bu çalışmada, CPV-2li köpeklerde cTn-I konsantrasyonunun klinik öneminin değerlendirilmesi amaçlandı. Çalışmanın materyalini değişik ırk ve her iki cinsiyetten 4-10 haftalık yaşta 25i hasta ve 25i sağlıklı olmak üzere 50 yavru köpek oluşturdu. Sağaltım uygulamasının başlatılmasına rağmen serum cTn-I konsantrasyonu > 0.8 ng/mL olan hasta köpeklerin 12si kliniğe getirildikten sonraki 24 saat içinde öldü. Kliniğe getirildikten sonra 24-72. saatlerde ölen 4 köpek ile sağaltım sonucu iyileşen 9 köpekte cTn-I konsantrasyonları <0.156 ng/mL (cut-off değeri) bulundu. Sağlıklı köpeklerde serum cTn-I konsantrasyonu 0,156 ng/ml değerinin (cut-off) altında saptandı. CTn-I konsantrasyonu karşılaştırıldığında ölen ve iyileşen köpekler arasında önemli farklılık saptandı (p<0.001). Serum cTn-I konsanrasyonu> 0.8 ng/mL olan köpeklerde yaşam zamanı 1 gün iken cTn-I konsantrasyonı <0.156 ng/mL olan köpeklerde ortalama yaşam süresi 2.5 gün (p<0,001) olarak hesaplandı.Serum cTn-I konsantrasyonu açısından değerlendirildiğinde yaş ortalamaları arasında istatiksel olarak önemli bir farklılık bulunmadı (p>0.05). Ölen 12 köpeğin (cTn-I > 0.8 ng/mL) nekropsisinde kalbin histopatolojik incelemesinde myokarditise bağlı patolojik değişiklikler belirlenirken ölen diğer 4 köpekte (cTn-I<0.156) kalp kasında herhangi bir patolojik değişikliğe rastlanmadı. Sonuç olarak bu çalışma serum cTn-I konsantrasyonunun 0.8 ng/mL nin üstünde olması kötü prognozun belirleyicisi olduğunu ve yüksek serum cTn- I konsantrasyonu ile kısa yaşam süresi arasında ilişki olduğunu gösterdi.

Anahtar Kelime:

Konular: Veterinerlik

CPV-2 infeksiyonlu köpeklerde Serum Kardiyak Troponin-I

Öz:

Summary: The objective of study was to determine the clinical significance of serum cTn-I level in dogs infected with Canine parvovirus-2 (CPV-2). The study material consisted of 4- to 10-week-old puppies of either sexes and 8 different breeds of twenty five dogs with CPV-2. Control group consisted of 4- to 10-week-old puppies of either sexes and 7 different breeds of twenty five dogs. Although treatment, 12 of the dogs with serum cTn-I level > 0.8 ng/mL died within 24 hours of admission. Remaining 13 dogs, had the serum cTn-I level <0.156 ng/mL (cut-off). Of 13 dogs, 4 died within 24-72 hours of admission and 9 were recovered. In terms of cTn-I concentration, whether below 0.156 ng/mL or above 0.8 ng/mL there was a statistically significant difference between survivor and non-survivor animals (p<0.001). Construction of Kaplan-Meier, survival curves revealed dogs with a cTn-I concentration > 0.8 ng/mL had survival time of 1 day, whereas dogs with a cTn-I concentration <0.156 ng/mL had a median survival time of 2.5 days (p<0,001). No statistically significant difference was determined between the mean ages of two groups (dogs with cTn-I concentration <0.156 and > 0.8 ng/mL) (p>0.05). At necropsy, the histopathological examination of the heart revealed the presence of pathological myocarditis findings in 12 of the non-survivor dogs (cTn-I > 0.8 ng/mL), whilst in the other non-survivor 4 dogs (cTn-I<0.156), no pathological alteration was observed in the myocardium. The present study demonstrated that serum cTn-I concentrations > 0.8 ng/mL were indicators of poor prognosis and increased serum cTn-I concentrations were consistent with short survival times in dogs with CPV-2.

Anahtar Kelime:

Konular: Veterinerlik

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

TRDizin Dışındaki Atıf Sayıları

OpenCitations: 0

OpenAlex: 0

Crossref: 0

Babuin L, Jaffe AS (2005): Troponin: the biomarker of choice for the detection of cardiac injury. Canadian Medical Association , 173: 11911202.
Baumwart RD, Orvalho J, Meurs KM (2007). Evaluation of serum cardiac troponin I concentration in Boxers with arrhythmogenic right ventricular cardiomyopathy. Am J Vet Res, 68: 524-8.
DeFrancesco TC, Atkins CE, Keene BW, Coats JR, Hauck ML (2002). Prospective clinical evaluation of serum cardiac troponin T in dogs admitted to a veterinary teaching hospital. J Vet Intern Med, 1: 553557.
Diniz PPVP, Morais HSA, Breitschwerdt EB, Schwartz (2008): Serun Cardiac Troponin I Concentration in Dogs with Erlichiosis. J Vet Intern Med, 22: 1136-1143.
Fonfara S, Loureiro J, Swift S, James R, Cripps P, Dukes-McEwan J (2010): Cardiac troponin I as a marker for severity and prognosis of cardiac disease in dogs. Vet J, 184: 334-9.
Goddard A, Leisewitz MM (2010). Canine Parvovirus Vet Clin North Am Small Anim Pract. 4: 1041-53.
Guglielmini C, Civitella C, Diana A, Di Tommaso M, Cipone M, Luciani A (2010): Serum Cardiac troponin I concentration in dogs with precapillary and postcapillary pulmonary hypertension. J Vet Intern Med, 24: 145-52.
Hoskins JD (1997): Update on canine parvoviral enteritis. Vet Med, 92, 694709.
Lenghaus C, Studdert MJ (1982): Acute and chronic viral myocarditis. Acute diffuse nonsuppurative myocarditis and residual myocardial scarring following infection with canine parvovirus. Am J Pathol, 115: 316319.
Lobetti R, Dvir E, Pearson J (2002). Cardiac troponins in canine babesiosis. J Vet Intern Med, 16:6368.
McCandlish IAP (1999): Specific Infactions of the dog. 921-958. In: Dunn J Textbook Small Animal Medicine.
Mellor PJ, Richard JM, Elizabeth AB, Elizabeth JV, Joy A, Michael E H (2006). High serum troponin I concentration as a marker of severe myocardial damage in a case of suspected exertional heatstroke in a dog. Journal or Veterinary Cardiology, 8: 55-62.
Nappert G, Duphy E, Ruben D, Mann FA (2002). Determination of serum organic acids in puppies with naturally acquired parvoviral enteritis. The Canadian Journal of Veterinary Research, 66: 15-18.
Nelson RW (2009) :Small Animal Internal Medicine, fourt edition, Elsevier, China.
Noszczyk-Nowak A (2011): NT-pro-BNP and troponin I as predictors of mortality in dogs with heart failure. Pol J Vet Sci, 14: 551-6.
Porciello F, Rishniw WM, Herndon W, Birettoni F, Antognooni MT, Simpson KW (2008): Cardiac troponin I is elevated in dogs and cats with azotemia renal failure and in dogs with non-cardiac systemic disease. Australian Veterinary Journal, 86, 10: 390-394.
Prittie J (2004): Canine parvoviral enteritis: a reviewdiagnosis, management, and prevention. J Vet Emerg Crit Care, 14: 167-176
Ricchiuti V, Sharkey SW, Murakami MM, Voss EM, Apple FS (1998). Cardiac troponin I and T alterationsdog hearts with myocardial infarction: correlation with infarct size. Am J Clin Pathol, 110: 241247.
Robinson WF, Huxtable CR, Pass DA, Howell JM (1979). Clinical and electrocardiographic findingssuspected viral myocarditis of pups. Aust Vet J, 55: 3.
Schober KE, Cornand C, Kirbach B, AupperleOechtering G (2002): Serum cardiac tro-ponin I and cardiac troponin T concentrations in dogs with gastric dilatation-volvulus. J Am Vet Med Assoc, 221: 381388.
Schober KE, Kirbach B, Oechtering G (1999). Noninvasive assessment of myocardial cell injury in dogs with suspected cardiac contusion. J Vet Cardiol,1: 1725.
Shih AC, Maisenbacher HW, Barreirinha A, Adin DB, Schmidt MK, Prosek R, Estrada AH (2009): Effectroutine cardiovascular catheterization in dogs. JournalVeterinary Cardiology, 11: 87-92.
Spratt DP, Mellanby RJ, Drury N, Archer J (2005): Cardiac troponin I: evaluation of a biomarker fordiagnosis of heart disease in the dog. J Small Anim Pract, 46: 139-145.
Turk J, Fales W, Miller M, Pace L, Fischer J, Johnson G, Kreeger J, Turnquist S, Pittman L, Rottinghaus(1992). Enteric Clostridium perfringens infection associated with parvoviral enteritis in dogs: 74 cases (1987-1990). J Am Vet Med Assoc, 200: 991-4.
Turk J, Miller M, Brown T, Fales W, Fischer J, Gosser H, Nelson S, Shaw D, Solorzano R (1990). Coliform septicemia and pulmonary disease associated with canine parvoviral enteritis: 88 cases (1987-1988). J Am Vet Med Assoc, 196: 771-3.
Oyama MA, Sisson DD (2004). Cardiac troponin-I concentration in dogs with cardiac disease. J Vet Intern Med, 18: 831-9.
Ozkul A, Keles I, Karaoglu T, Çabalar M, Burgu(2002): Detection and rflp analysis of canine parvovirus (cpv) dna by polymerase chain reaction (pcr) in a dog. Turk J Vet Anim Sci, 6: 12011203.

APA	BASTAN I, KURTDEDE A, BAYDIN A, SEL T, OZEN D, Yumusak N, TIMURKAN M (2013). Serum Cardiac Troponin-I in dogs with CPV-2 infection. , 251 - 255.
Chicago	BASTAN IDIL,KURTDEDE ARIF,BAYDIN Ahmet,SEL Tevhide,OZEN DOGUKAN,Yumusak Nihat,TIMURKAN M. Özkan Serum Cardiac Troponin-I in dogs with CPV-2 infection. (2013): 251 - 255.
MLA	BASTAN IDIL,KURTDEDE ARIF,BAYDIN Ahmet,SEL Tevhide,OZEN DOGUKAN,Yumusak Nihat,TIMURKAN M. Özkan Serum Cardiac Troponin-I in dogs with CPV-2 infection. , 2013, ss.251 - 255.
AMA	BASTAN I,KURTDEDE A,BAYDIN A,SEL T,OZEN D,Yumusak N,TIMURKAN M Serum Cardiac Troponin-I in dogs with CPV-2 infection. . 2013; 251 - 255.
Vancouver	BASTAN I,KURTDEDE A,BAYDIN A,SEL T,OZEN D,Yumusak N,TIMURKAN M Serum Cardiac Troponin-I in dogs with CPV-2 infection. . 2013; 251 - 255.
IEEE	BASTAN I,KURTDEDE A,BAYDIN A,SEL T,OZEN D,Yumusak N,TIMURKAN M "Serum Cardiac Troponin-I in dogs with CPV-2 infection." , ss.251 - 255, 2013.
ISNAD	BASTAN, IDIL vd. "Serum Cardiac Troponin-I in dogs with CPV-2 infection". (2013), 251-255.

APA	BASTAN I, KURTDEDE A, BAYDIN A, SEL T, OZEN D, Yumusak N, TIMURKAN M (2013). Serum Cardiac Troponin-I in dogs with CPV-2 infection. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 60(4), 251 - 255.
Chicago	BASTAN IDIL,KURTDEDE ARIF,BAYDIN Ahmet,SEL Tevhide,OZEN DOGUKAN,Yumusak Nihat,TIMURKAN M. Özkan Serum Cardiac Troponin-I in dogs with CPV-2 infection. Ankara Üniversitesi Veteriner Fakültesi Dergisi 60, no.4 (2013): 251 - 255.
MLA	BASTAN IDIL,KURTDEDE ARIF,BAYDIN Ahmet,SEL Tevhide,OZEN DOGUKAN,Yumusak Nihat,TIMURKAN M. Özkan Serum Cardiac Troponin-I in dogs with CPV-2 infection. Ankara Üniversitesi Veteriner Fakültesi Dergisi, vol.60, no.4, 2013, ss.251 - 255.
AMA	BASTAN I,KURTDEDE A,BAYDIN A,SEL T,OZEN D,Yumusak N,TIMURKAN M Serum Cardiac Troponin-I in dogs with CPV-2 infection. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2013; 60(4): 251 - 255.
Vancouver	BASTAN I,KURTDEDE A,BAYDIN A,SEL T,OZEN D,Yumusak N,TIMURKAN M Serum Cardiac Troponin-I in dogs with CPV-2 infection. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2013; 60(4): 251 - 255.
IEEE	BASTAN I,KURTDEDE A,BAYDIN A,SEL T,OZEN D,Yumusak N,TIMURKAN M "Serum Cardiac Troponin-I in dogs with CPV-2 infection." Ankara Üniversitesi Veteriner Fakültesi Dergisi, 60, ss.251 - 255, 2013.
ISNAD	BASTAN, IDIL vd. "Serum Cardiac Troponin-I in dogs with CPV-2 infection". Ankara Üniversitesi Veteriner Fakültesi Dergisi 60/4 (2013), 251-255.