Relationship between oxidative stress markers and cardiac syndrome X

ÇAYLI, Murat; SÜMBÜL, Zehra; türkoğlu, caner; GÜR, MUSTAFA; ŞAHİN, Durmuş Yıldıray; Ozdemir, Betul; ELBASAN, Zafer

Relationship between oxidative stress markers and cardiac syndrome X

Durmuş Yıldıray ŞAHİN, (Sağlık Bakanlığı, Adana Numune Eğitim Ve Araştırma Hastanesi, Kardiyoloji Bölümü Adana, Türkiye)

Zafer ELBASAN, (Sağlık Bakanlığı, Adana Numune Eğitim Ve Araştırma Hastanesi, Kardiyoloji Bölümü Adana, Türkiye)

Mustafa GÜR, (Sağlık Bakanlığı, Adana Numune Eğitim Ve Araştırma Hastanesi, Kardiyoloji Bölümü Adana, Türkiye)

Caner TÜRKOĞLU, (Sağlık Bakanlığı, Adana Numune Eğitim Ve Araştırma Hastanesi, Kardiyoloji Bölümü Adana, Türkiye)

Betül ÖZALTUN, (Sağlık Bakanlığı, Adana Numune Eğitim Ve Araştırma Hastanesi, Kardiyoloji Bölümü Adana, Türkiye)

Zehra SÜMBÜL, (Sağlık Bakanlığı, Adana Numune Eğitim Ve Araştırma Hastanesi, Kardiyoloji Bölümü Adana, Türkiye)

Murat ÇAYLI (Sağlık Bakanlığı, Adana Numune Eğitim Ve Araştırma Hastanesi, Kardiyoloji Bölümü Adana, Türkiye)

Journal of Clinical and Experimental Investigations

0 1

Yıl: 2012 Cilt: 3 Sayı: 2 Sayfa Aralığı: 174 - 180 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Relationship between oxidative stress markers and cardiac syndrome X

Öz:

Amaç: Biz bu çalışmada kardiyak sendrom X’li (CSX) hastalarda oksidatif ve antioksidatif durumlardaki değişi- mi araştırdık. Gereç ve yöntem: Çalışmamıza 33 CSX’li hasta, 27 CSX tanısı olmayan (NSX) hasta ve kontrol grubu olarak 20 sağlıklı gönüllüyü dahil ettik. Serumun oksidatif durumu total oksidan durum (TOS), lipid hidroperoksid seviyesi (LOOH) ve serum oksidatif stres indeksi ölçülerek (OSİ) değerlendirildi. Serumun antioksidatif durumu ise total an- tioksidan kapasite (TAC) ölçülerek değerlendirildi. Ayrıca tüm vakalarda hsCRP ve diğer biyokimyasal belirteçler ölçüldü. Bulgular: CSX grubunda NSX ve kontrol grubuna göre oksidan seviyeleri (TOS, LOOH ve OSI) ve CRP seviye- leri daha yüksekken, TAC seviyeleri daha düşük bulundu. Ayrıca NSX grubunda kontrol grubuna göre oksidanlar (TOS, LOOH ve OSI) ve kronik enflamasyonun bir belir- teci olan hsCRP seviyeleri daha yüksekken TAC seviye- leri daha düşük olarak saptandı. Bunlara ek olarak CSX’li hastalarda OSİ seviyesi ve ST depresyonu arasında ista- tistiksel olarak anlamlı bir korelasyon mevcuttu (r; 0.784, ß =0,606, p<0,001). Sonuç: CSX’li hastalarda oksidanlarda artış antioksidan- larda düşüş yani oksidatif -antioksidatif dengede oksidatif stres yönüne kayış görülmektedir. Bundan dolayı oksidatif stres bu sendromun patogenezinde rol oynayan bir faktör olabilir.

Anahtar Kelime:

Konular: Cerrahi

Oksidatif stres belirteçleri ile kardiyak sendrom X arasındaki ilişki

Öz:

Objectives: To investigate the alterations of oxidative and antioxidative status in patients with cardiac syndrome X (CSX). Materials and methods: Thirty-three patients with CSX (CSX group), 27 patients without CSX (NSX) and 20 healthy volunteers as control group were included into the study. Oxidative status of serum was evaluated by measuring total oxidant status (TOS), lipid hydroperoxide levels (LOOH) and oxidative stress index (OSI) of serum, and antioxidative status of serum was evaluated by mea- suring total antioxidant capacity (TAC). Also, hsCRP and other biochemical markers were measured in all subjects. Results: The oxidants (TOS, LOOH and OSI) and CRP levels were higher, and TAC was lower in the patients with CSX than NSX group and control group. Also, the oxi- dants (TOS, LOOH and OSI) and hsCRP levels, a marker of chronic inflammation, were higher, and TAC was lower in the patients with NSX than control group. In addition, in patients with CSX, a significant positive correlation (ß =0.606, p<0.001) was found between the OSI level and ST depression. Conclusion: Oxidants increased and antioxidants de- creased, namely oxidative/antioxidative balance shifted to oxidative stress in patients with CSX. Thus, oxidative stress may have a role in the etiopathogenesis of the dis- ease.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ŞAHİN D, ELBASAN Z, GÜR M, türkoğlu c, Ozdemir B, SÜMBÜL Z, ÇAYLI M (2012). Relationship between oxidative stress markers and cardiac syndrome X. , 174 - 180.
Chicago	ŞAHİN Durmuş Yıldıray,ELBASAN Zafer,GÜR MUSTAFA,türkoğlu caner,Ozdemir Betul,SÜMBÜL Zehra,ÇAYLI Murat Relationship between oxidative stress markers and cardiac syndrome X. (2012): 174 - 180.
MLA	ŞAHİN Durmuş Yıldıray,ELBASAN Zafer,GÜR MUSTAFA,türkoğlu caner,Ozdemir Betul,SÜMBÜL Zehra,ÇAYLI Murat Relationship between oxidative stress markers and cardiac syndrome X. , 2012, ss.174 - 180.
AMA	ŞAHİN D,ELBASAN Z,GÜR M,türkoğlu c,Ozdemir B,SÜMBÜL Z,ÇAYLI M Relationship between oxidative stress markers and cardiac syndrome X. . 2012; 174 - 180.
Vancouver	ŞAHİN D,ELBASAN Z,GÜR M,türkoğlu c,Ozdemir B,SÜMBÜL Z,ÇAYLI M Relationship between oxidative stress markers and cardiac syndrome X. . 2012; 174 - 180.
IEEE	ŞAHİN D,ELBASAN Z,GÜR M,türkoğlu c,Ozdemir B,SÜMBÜL Z,ÇAYLI M "Relationship between oxidative stress markers and cardiac syndrome X." , ss.174 - 180, 2012.
ISNAD	ŞAHİN, Durmuş Yıldıray vd. "Relationship between oxidative stress markers and cardiac syndrome X". (2012), 174-180.

APA	ŞAHİN D, ELBASAN Z, GÜR M, türkoğlu c, Ozdemir B, SÜMBÜL Z, ÇAYLI M (2012). Relationship between oxidative stress markers and cardiac syndrome X. Journal of Clinical and Experimental Investigations, 3(2), 174 - 180.
Chicago	ŞAHİN Durmuş Yıldıray,ELBASAN Zafer,GÜR MUSTAFA,türkoğlu caner,Ozdemir Betul,SÜMBÜL Zehra,ÇAYLI Murat Relationship between oxidative stress markers and cardiac syndrome X. Journal of Clinical and Experimental Investigations 3, no.2 (2012): 174 - 180.
MLA	ŞAHİN Durmuş Yıldıray,ELBASAN Zafer,GÜR MUSTAFA,türkoğlu caner,Ozdemir Betul,SÜMBÜL Zehra,ÇAYLI Murat Relationship between oxidative stress markers and cardiac syndrome X. Journal of Clinical and Experimental Investigations, vol.3, no.2, 2012, ss.174 - 180.
AMA	ŞAHİN D,ELBASAN Z,GÜR M,türkoğlu c,Ozdemir B,SÜMBÜL Z,ÇAYLI M Relationship between oxidative stress markers and cardiac syndrome X. Journal of Clinical and Experimental Investigations. 2012; 3(2): 174 - 180.
Vancouver	ŞAHİN D,ELBASAN Z,GÜR M,türkoğlu c,Ozdemir B,SÜMBÜL Z,ÇAYLI M Relationship between oxidative stress markers and cardiac syndrome X. Journal of Clinical and Experimental Investigations. 2012; 3(2): 174 - 180.
IEEE	ŞAHİN D,ELBASAN Z,GÜR M,türkoğlu c,Ozdemir B,SÜMBÜL Z,ÇAYLI M "Relationship between oxidative stress markers and cardiac syndrome X." Journal of Clinical and Experimental Investigations, 3, ss.174 - 180, 2012.
ISNAD	ŞAHİN, Durmuş Yıldıray vd. "Relationship between oxidative stress markers and cardiac syndrome X". Journal of Clinical and Experimental Investigations 3/2 (2012), 174-180.