Association between age at onset of schizophrenia and age at menarche

METE, Levent; Kılıçaslan, Esin Evren; AYDIN ÇETİNAY, Pınar; ZENGİN, Burçak; EROL, Almıla

Association between age at onset of schizophrenia and age at menarche

Esin Evren KILIÇASLAN, (Atatürk Eğitim ve Araştırma Hastanesi, Psikiyatri Kliniği, İzmir, Türkiye)

Almıla EROL, (Atatürk Eğitim ve Araştırma Hastanesi, Psikiyatri Kliniği, İzmir, Türkiye)

Burçak ZENGİN, (Şifa Üniversitesi Hastanesi, Psikiyatri Bölümü, İzmir, Türkiye)

Pınar AYDIN ÇETİNAY, (Bakırköy Araştırma Eğitim Hastanesi, Psikiyatri ve Nöroloji ve Nöropsikiyatri, Psikiyatri Kliniği, İstanbul, Türkiye)

Levent METE (Atatürk Eğitim ve Araştırma Hastanesi, Psikiyatri Kliniği, İzmir, Türkiye)

Nöropsikiyatri Arşivi

2 0

Yıl: 2014 Cilt: 51 Sayı: 3 Sayfa Aralığı: 211 - 215 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Association between age at onset of schizophrenia and age at menarche

Öz:

Giriş: Epidemiyolojik ve laboratuara dayalı araştırmalar kadar klinik kanıtlar da östrojenin kadınların ruhsal durumu üzerinde anlamlı etkisi olduğunu göstermektedir. Bu konu ile ilgili yapılan araştırmalarda şizofrenide belirli özellikler açısından cinsiyete dair farklılıklar olduğu bilinmekte; bunda östrojenin kadın şizofreni hastalarında koruyucu rolünün etkisi olduğu hipotezi öne sürülmektedir. Bu çalışmada, bizim amacımız kadın şizofreni hastalarında şizofreni başlangıç yaşı ile menarş yaşı arasındaki korelasyonu araştırarak, östrojenin şizofrenide koruyucu etkisini sorgulamaktır. Yöntem: SCID görüşmesi sonucunda şizofreni tanısı onaylanan 289 hasta çalışmaya dahil edildi. Zeka geriliği ya da bilinen organik beyin hastalığı (epilepsi, inme vb.) bulunan hastalar çalışmaya alınmadı. Verilen sosyodemografik form ile hastaların kişisel bilgileri, ilk tuhaf davranış yaşı, şizofreni başlangıç yaşı, ilk hastaneye yatış yaşı ve ilk adet yaşı hasta ve bir yakını ile görüşülerek belirlendi. Şizofreni başlangıç yaşı ile puberte başlangıç yaşı arasındaki ilişkiyi etkileyebilecek olan veriler (aile öyküsü, kafa veya doğum travması gibi) sosyodemografik forma kaydedildi. Bulgular: Yaptığımız çalışmada menarş yaşı ile ilk tuhaf davranış ve ilk hastalık başlangıç yaşı arasında anlamlı negatif korelasyon olduğu sonucu ortaya çıktı. Sonuç: Çalışmamız östrojenin koruyucu etkisiyle ilgili verileri desteklemekte; pubertenin erken başlamasının yani erken östrojen salınımının, şizofreni başlangıcının gecikmesine neden olabileceğini göstermektedir. Psikiyatride cinsiyet odaklı bir yaklaşım hastalıkları ve tedavi yaklaşımlarına olan bakış açımızı geliştirecektir.

Anahtar Kelime:

Konular: Nörolojik Bilimler Psikiyatri

Şizofreni başlangıç yaşı ile menarş yaşı arasındaki ilişki

Öz:

Introduction: Increasing evidence from clinical practice, as well as from epidemiological and basic research shows that there are gender differences in clinical features of schizophrenia, and this may be related to estrogens. There may be a relationship between earlier puberty and later onset of the disease, because of the protective effects of estrogens in women with schizophrenia. In this study, our aim was to analyze the correlation between age of menarche and age of onset of schizophrenia and to investigate the protective effects of estrogens in schizophrenia. Method: In this study, we included 289 patients who were diagnosed with schizophrenia. Those with mental deficiency or organic brain disorders were excluded from the study. All subjects were given a socio-demographic form to determine their personal information, age at menarche, age at first odd behavior, age at onset of the disease and first hospitalization. Data on factors which may affect the association between age at onset of schizophrenia and age at menarche such as family history, head or birth trauma etc. were recorded on the information form. Results: We found out that age at menarche was negatively associated with age at first odd behavior and age at first psychotic symptoms. Conclusion: Our study verifies the protective effects of estrogens and shows that the earlier puberty may be the cause of later onset of schizophrenia. A gender-sensitive approach in psychiatry improves our understanding of mental illness and our therapeutic strategies.

Anahtar Kelime:

Konular: Nörolojik Bilimler Psikiyatri

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Riecher-Rössler A, Hafner H. Schizophrenia and oestrogens- is there an association? Eur Arch Psychiatry Clin Neurosci 1993; 242:323-328.
2. Castle DJ, Abel K, Takei N, Murray RM. Gender difference in schizophrenia: hormonal effect or subtypes. Schizophr Bull 1995; 21:1-12.
3. Kulkarni J. Women and schizophrenia: a review. Aust New Zeal J Psychiatry 1997; 31:46- 56.
4. Erol A. Kadın üreme yaşamı ve şizofreni. Türk Psikiyatri Dizini 2005; 13:41-44.
5. Nicole L, Shriqui CL. Gender differences in schizophrenia. In Nasrallah (edt) Washington, 1995 American Psychiatric Press, p; 225-243.
6. Lindamer LA, Lohr JB, Harris MJ, Jeste DV. Gender, estrogen and schizophrenia. Psychopharmacol Bull 1997; 33:211-228.
7. Foerster A, Lewis S, Owen M, Murray R. Premorbid adjustment and personality in psychosis: effects of sex and diagnosis. Br J Psychiatry 1991; 58:171-176.
8. Salokangas RKR. Prognostic implications of the sex of schizophrenic patients. Br J Psychiatry 1983; 142:145-151.
9. Nasrallah HA, Schwarzkopf SB, Olson SC, Coffman JA. Gender differences in schizophrenia on MRI scans. Schizophr Bull 1990; 16:205-210.
10. Lane A, Colgan K, Moynihan F, Burke T, Waddington JL, Larkin C, OCallaghan E. Schizophrenia and neurologic soft signs: gender differences in clinical correlates and accedent factors. Psychiatry Res 1996; 64:105-114.
11. Halari R, Kumari V, Mehrotra R, Wheeler M, Hines M, Sharma T. The relationship of sex hormones and cortisol with cognitive functioning in schizophrenia. J Psychopharmacol 2004; 18:366-374.
12. Kaya MC, Virit O, Altındağ A, et al. Prevalence of metabolic syndrome, characteristics of metabolic syndrome and relationship with the antipsychotics used in schizophrenia. Arch of Neuropsychiatry 2009; 46:13-18.
13. Cohn T, Prudhomme D, Streiner D, Kameh H, Remington G. Characterizing coronary heart disease risk in chronic schizophrenia: high prevalence of the metabolic syndrome. Can J Psychiatry 2004; 49:753-760.
14. McEvoy JP, Meyer JM, Goff DC, Nasrallah HA, Davis SM, Sullivan L, Meltzer HY, Hsiao J, Scott Stroup T, Lieberman JA. Prevalence of the metabolic syndrome in patients with schizophrenia: baseline results from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial and comparison with national estimates from NHANES III. Schizophr Res 2005; 80:19-32.
15. Bardenstein KK, McGlashan TH. Gender differences in affective, schizoaffective and schizohrenic disorders: a review. Schizophr Res 1990; 3:159-172.
16. Ring N, Tantam D, Montague L, Newby D, Black D, Morris J. Gender differences in the incidance of definite schizophrenia and atypical psychosis on negative symptoms of schizophrenia. Acta Psychiatr Scand 1991; 84:489-496.
17. Goldstein JM. Gender differences in the course of schizophrenia. Am J Psychiatry 1988; 145:684-689.
18. Kolakowska T, Williams AO, Ardern M, Reveley MA, Jambor K, Gelder MG, Mandelbrote BM. Schizophrenia with good and poor outcome: early clinical features response to neuroleptics and signs of organic dysfunction. Br J Psychiatry 1985; 146:229-239.
19. Guz H. Schizophrenia and gender. Anatolian J Psychiatry 2000; 3:180-185.
20. Doğu B, Kocabıyık A, Farson F, et al. The Intersexual Differences of Sexual Functions and Prolactine Levels in Schizophrenia Patients Under Antipsychotic Medication. Arch of Neuropsychiatry 2011; 48:35-38.
21. Hallonquist JD, Seeman MV, Lang M, Rector NA. Variation in syptom severity over the menstruel cycle of schizophrenics. Biol Psychiatry 1993; 33:207-209.
22. Riecher-Rössler A, Häfner H, Dütsch-Strobel A, Oster M, Stumbaum M, van Gülick-Bailer M, Löffler W. Further evidence for a specific role of estradiol in schizophrenia? Biol Psychiatry 1994; 36:492-495.
23. Yucel A. Correlation between estradiol and clinical psychopathology in schizophrenic women through the menstrual cyclus. Bull Clin Psychopharmacol 1999; 9:53-56.
24. Seeman MV, Lang M. The role of oestrogenes in schizophrenia gender diferences. Schizophr Bull 1990; 16:185-195.
25. Hafner H. Gender differences in schizophrenia. Psychoneuroendocrinology 2003; 28:17-54.
26. Green PS, Simpkins JW. Neuroprotective effects of estrogens: potential mechanisms of action. Int J Dev Neurosci 2000; 18:347-358.
27. Cohen RZ, Seeman MV, Gotowiec A, Kopala L. Early puberty as a predictor of later onset of schizophrenia in women. Am J Psychiatry 1999; 156:1059-1064.
28. Ruiz A, Blanco R, Santander J, Miranda E. Relationship between sex differences in onset of schizophrenia and puberty. J Psychiatr Res 2000; 34:349-353.
29. Hochman KM, Lewine RR. Age of menarche and schizophrenia onset in women. Sch Research 2004; 69;183-188.
30. First MB, Spitzer RL, Gibbon M ve ark. Structed Clinical interview for DSM IV Axis Disorders (SCID-1) Clinical version. Washington D.C. and London: American Psychiatric Pres, 1997.
31. Çorapçıoğlu A, Aydemir Ö, Yıldız M ve ark. DSM IV Eksen 1 bozuklukları (SCID-1) için yapılandırılmış klinik görüşme. Klinik versiyon. Ankara: Hekimler Yayın Birliği, 1999.
32. Gilger JW, Geary DC, Eisele LM. Reliability and validity of retrospective self reports of the age of pubertal onset using twin, sibling, and college student data. Adolescence 1991; 26:41-53.
33. Casey VA, Dwyer JT, Coleman KA, Krall EA, Gardner J, Valadian I. Accuracy of recall by middle-aged participants in a longitudinal study of their body size and indices of maturation earlier in life. Ann Hum Biol 1991; 18:155-166.
34. Riecher-Rossler A, Hafner H. Gender aspects in schizophrenia: bridging the border between social and biological psychiatry. Acta Psychiatr Scand Suppl 2000; 407:58-62.

APA	Kılıçaslan E, EROL A, ZENGİN B, AYDIN ÇETİNAY P, METE L (2014). Association between age at onset of schizophrenia and age at menarche. , 211 - 215.
Chicago	Kılıçaslan Esin Evren,EROL Almıla,ZENGİN Burçak,AYDIN ÇETİNAY Pınar,METE Levent Association between age at onset of schizophrenia and age at menarche. (2014): 211 - 215.
MLA	Kılıçaslan Esin Evren,EROL Almıla,ZENGİN Burçak,AYDIN ÇETİNAY Pınar,METE Levent Association between age at onset of schizophrenia and age at menarche. , 2014, ss.211 - 215.
AMA	Kılıçaslan E,EROL A,ZENGİN B,AYDIN ÇETİNAY P,METE L Association between age at onset of schizophrenia and age at menarche. . 2014; 211 - 215.
Vancouver	Kılıçaslan E,EROL A,ZENGİN B,AYDIN ÇETİNAY P,METE L Association between age at onset of schizophrenia and age at menarche. . 2014; 211 - 215.
IEEE	Kılıçaslan E,EROL A,ZENGİN B,AYDIN ÇETİNAY P,METE L "Association between age at onset of schizophrenia and age at menarche." , ss.211 - 215, 2014.
ISNAD	Kılıçaslan, Esin Evren vd. "Association between age at onset of schizophrenia and age at menarche". (2014), 211-215.

APA	Kılıçaslan E, EROL A, ZENGİN B, AYDIN ÇETİNAY P, METE L (2014). Association between age at onset of schizophrenia and age at menarche. Nöropsikiyatri Arşivi, 51(3), 211 - 215.
Chicago	Kılıçaslan Esin Evren,EROL Almıla,ZENGİN Burçak,AYDIN ÇETİNAY Pınar,METE Levent Association between age at onset of schizophrenia and age at menarche. Nöropsikiyatri Arşivi 51, no.3 (2014): 211 - 215.
MLA	Kılıçaslan Esin Evren,EROL Almıla,ZENGİN Burçak,AYDIN ÇETİNAY Pınar,METE Levent Association between age at onset of schizophrenia and age at menarche. Nöropsikiyatri Arşivi, vol.51, no.3, 2014, ss.211 - 215.
AMA	Kılıçaslan E,EROL A,ZENGİN B,AYDIN ÇETİNAY P,METE L Association between age at onset of schizophrenia and age at menarche. Nöropsikiyatri Arşivi. 2014; 51(3): 211 - 215.
Vancouver	Kılıçaslan E,EROL A,ZENGİN B,AYDIN ÇETİNAY P,METE L Association between age at onset of schizophrenia and age at menarche. Nöropsikiyatri Arşivi. 2014; 51(3): 211 - 215.
IEEE	Kılıçaslan E,EROL A,ZENGİN B,AYDIN ÇETİNAY P,METE L "Association between age at onset of schizophrenia and age at menarche." Nöropsikiyatri Arşivi, 51, ss.211 - 215, 2014.
ISNAD	Kılıçaslan, Esin Evren vd. "Association between age at onset of schizophrenia and age at menarche". Nöropsikiyatri Arşivi 51/3 (2014), 211-215.