Characterization of HCV genotype 4d infections in Kayseri, Turkey

Ergör, Gül; Polat, Ceylan; ABACIOĞLU, Yusuf Hakan; KAYMAN, Tuba

Characterization of HCV genotype 4d infections in Kayseri, Turkey

Tuba KAYMAN, (SB Kayseri Eğitim ve Araştırma Hastanesi, Mikrobiyoloji Kliniği, Kayseri, Türkiye)

Ceylan POLAT, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, İzmir, Türkiye)

Yusuf Hakan ABACIOĞLU, (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, İzmir, Türkiye)

Gül ERGÖR (Dokuz Eylül Üniversitesi, Tıp Fakültesi, Halk Sağlığı Anabilim Dalı, İzmir, Türkiye)

Turkish Journal of Medical Sciences

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Yıl: 2015 Cilt: 45 Sayı: 3 Sayfa Aralığı: 547 - 552 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Characterization of HCV genotype 4d infections in Kayseri, Turkey

Öz:

Background/aim: The frequency of genotype 4 hepatitis C virus (HCV) infections is significantly higher in Kayseri compared to other provinces in Turkey. We aimed to characterize genotype 4 infections in Kayseri by analyzing the demographic and laboratory data of 218 HCV RNA-positive, treatment-naive patients admitted to the Kayseri Training and Research Hospital in 2010 and 2011. Materials and methods: The distributions of sex, age, and viral loads of these patients with respect to HCV genotypes were analyzed. We also characterized the type 4 sequences at the subtype level. Randomly selected sera from 32 of the 72 genotype 4 patients from this cohort were subjected to PCR amplification in the NS5B region and further characterized by sequencing and phylogenetic and molecular clock analysis. Results: Distribution rates of HCV genotypes 1, 4, and 2 in the 218 patients were 62.4%, 33.0%, and 4.6%, respectively. Most of the patients infected with types 1 and 4 were over the age of 40 and female. The NS5B sequences of 32 Kayseri genotype 4 isolates were closely related with type 4d sequences but formed a separate cluster. Conclusion: The introduction of type 4d HCV into the Kayseri region probably took place 30-75 years ago, as predicted by molecular clock analysis.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KAYMAN T, Polat C, ABACIOĞLU Y, Ergör G (2015). Characterization of HCV genotype 4d infections in Kayseri, Turkey. , 547 - 552.
Chicago	KAYMAN Tuba,Polat Ceylan,ABACIOĞLU Yusuf Hakan,Ergör Gül Characterization of HCV genotype 4d infections in Kayseri, Turkey. (2015): 547 - 552.
MLA	KAYMAN Tuba,Polat Ceylan,ABACIOĞLU Yusuf Hakan,Ergör Gül Characterization of HCV genotype 4d infections in Kayseri, Turkey. , 2015, ss.547 - 552.
AMA	KAYMAN T,Polat C,ABACIOĞLU Y,Ergör G Characterization of HCV genotype 4d infections in Kayseri, Turkey. . 2015; 547 - 552.
Vancouver	KAYMAN T,Polat C,ABACIOĞLU Y,Ergör G Characterization of HCV genotype 4d infections in Kayseri, Turkey. . 2015; 547 - 552.
IEEE	KAYMAN T,Polat C,ABACIOĞLU Y,Ergör G "Characterization of HCV genotype 4d infections in Kayseri, Turkey." , ss.547 - 552, 2015.
ISNAD	KAYMAN, Tuba vd. "Characterization of HCV genotype 4d infections in Kayseri, Turkey". (2015), 547-552.

APA	KAYMAN T, Polat C, ABACIOĞLU Y, Ergör G (2015). Characterization of HCV genotype 4d infections in Kayseri, Turkey. Turkish Journal of Medical Sciences, 45(3), 547 - 552.
Chicago	KAYMAN Tuba,Polat Ceylan,ABACIOĞLU Yusuf Hakan,Ergör Gül Characterization of HCV genotype 4d infections in Kayseri, Turkey. Turkish Journal of Medical Sciences 45, no.3 (2015): 547 - 552.
MLA	KAYMAN Tuba,Polat Ceylan,ABACIOĞLU Yusuf Hakan,Ergör Gül Characterization of HCV genotype 4d infections in Kayseri, Turkey. Turkish Journal of Medical Sciences, vol.45, no.3, 2015, ss.547 - 552.
AMA	KAYMAN T,Polat C,ABACIOĞLU Y,Ergör G Characterization of HCV genotype 4d infections in Kayseri, Turkey. Turkish Journal of Medical Sciences. 2015; 45(3): 547 - 552.
Vancouver	KAYMAN T,Polat C,ABACIOĞLU Y,Ergör G Characterization of HCV genotype 4d infections in Kayseri, Turkey. Turkish Journal of Medical Sciences. 2015; 45(3): 547 - 552.
IEEE	KAYMAN T,Polat C,ABACIOĞLU Y,Ergör G "Characterization of HCV genotype 4d infections in Kayseri, Turkey." Turkish Journal of Medical Sciences, 45, ss.547 - 552, 2015.
ISNAD	KAYMAN, Tuba vd. "Characterization of HCV genotype 4d infections in Kayseri, Turkey". Turkish Journal of Medical Sciences 45/3 (2015), 547-552.